Mutant p53 super(R175H) upregulates Twist1 expression and promotes epithelial-mesenchymal transition in immortalized prostate cells

A mutation within one allele of the p53 tumor suppressor gene can inactivate the remaining wild-type allele in a dominant-negative manner and in some cases can exert an additional oncogenic activity, known as mutant p53 'gain of function' (GOF). To study the role of p53 mutations in prosta...

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Veröffentlicht in:	Cell death and differentiation 2011-02, Vol.18 (2), p.271-281
Hauptverfasser:	Kogan-Sakin, I, Tabach, Y, Buganim, Y, Molchadsky, A, Solomon, H, Madar, S, Kamer, I, Stambolsky, P, Shelly, A, Goldfinger, N, Valsesia-Wittmann, S, Puisieux, A, Zundelevich, A, Gal-Yam, E N, Avivi, C, Barshack, I, Brait, M, Sidransky, D, Domany, E, Rotter, V
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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