The activity of several newer antimicrobials against logarithmically multiplying M. leprae in mice

Moxifloxacin, rifampicin, rifapentine, linezolid, and PA 824, alone and in combination, have been previously administered, as single doses and five times daily doses, to M. leprae infected mice during lag phase multiplication and were each found to have some bactericidal activity. The fluroquinolone...

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Veröffentlicht in:	Leprosy review 2011-09, Vol.82 (3), p.253-258
Hauptverfasser:	BURGOS, Jasmin, DE LA CRUZ, Eduardo, PAREDES, Rose, ANDAYA, Cora Revelyn, GELBER, Robert H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Infective Agents - therapeutic use Bacterial diseases Biological and medical sciences Dermatology Dose-Response Relationship, Drug Drug Therapy, Combination Fluoroquinolones - administration & dosage General aspects Human bacterial diseases Infectious diseases Leprosy Leprosy - drug therapy Leprosy - microbiology Medical sciences Mice Mice, Inbred CBA Microbial Sensitivity Tests Mycobacterium leprae - drug effects Mycobacterium leprae - growth & development Ofloxacin Quinolines - administration & dosage Rifampin Tropical bacterial diseases
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