Effects of somatostatin analogs on glucose homeostasis in rats

Pasireotide (SOM230) is a multireceptor-targeted somatostatin analog with high binding affinity for sstr1,2,3 and sstr5. The effects of pasireotide and octreotide on blood glucose, insulin, and glucagon levels in rats were evaluated alone and in combination. Single-dose s.c. pasireotide acutely elev...

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Veröffentlicht in:	Journal of endocrinology 2012-01, Vol.212 (1), p.49-60
Hauptverfasser:	Schmid, Herbert A, Brueggen, Josef
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood Glucose - drug effects Fundamental and applied biological sciences. Psychology Glucagon - blood Homeostasis - drug effects Hyperglycemia - chemically induced Insulin - blood Insulin-Like Growth Factor I - metabolism Male Octreotide - administration & dosage Rats Rats, Inbred Lew Receptors, Somatostatin - agonists Regular papers Somatostatin - administration & dosage Somatostatin - analogs & derivatives Vertebrates: endocrinology
Online-Zugang:	Volltext
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