Oxidative mechanisms for the biotransformation of 1-methyl-1,6-dihydropyridine-2-carbaldoxime to pralidoxime chloride

Due to pralidoxime chloride's (2-PAM) positive charge, it's penetration through the blood brain barrier (BBB) and reactivation of organophosphate (OP) inhibited central nervous system (CNS) acetylcholinesterase (AChE) is poor. The results of CNS inhibited AChE are seizures. Pro-2-PAM (1-me...

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Veröffentlicht in:	Life sciences (1973) 2011-12, Vol.89 (25-26), p.911-917
Hauptverfasser:	Khan, Farhat A., Campbell, Amy J., Hoyt, Benjamin, Herdman, Christine, Ku, Therese, Thangavelu, Sonia, Gordon, Richard K.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-1,6-dihydropyridine-2-carbaldoxime Acetylcholinesterase Acetylcholinesterase - metabolism Animals biotransformation Blood brain barrier brain Chromatography, High Pressure Liquid - methods flavin-adenine dinucleotide Guinea Pigs high performance liquid chromatography hydrophobicity in vitro studies kynurenine pathway NAD (coenzyme) NADP (coenzyme) NADPH oxidase NADPH Oxidases - metabolism Onium Compounds - pharmacology oxidation Oxidation-Reduction pralidoxime Pralidoxime chloride Pralidoxime Compounds - metabolism Pro-drug Prodrugs Rats Riboflavin Riboflavin - pharmacology seizures Spectrophotometry - methods
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