Evidence for insulin-mediated control of AQP9 expression in human placenta

Abstract The AQP9 gene contains a negative insulin response element, suggesting that it may be modulated by insulin. Previously, we reported AQP9 overexpression in preeclamptic placentas but a lack of functionality of AQP9 in water and mannitol transport. We also observed high serum levels of insuli...

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Veröffentlicht in:	Placenta (Eastbourne) 2011-12, Vol.32 (12), p.1050-1056
Hauptverfasser:	Castro Parodi, M, Farina, M, Dietrich, V, Abán, C, Szpilbarg, N, Zotta, E, Damiano, A.E
Format:	Artikel
Sprache:	eng
Schlagworte:	AQP9 Aquaporins - biosynthesis Biological and medical sciences Down-Regulation Embryology: invertebrates and vertebrates. Teratology Female Fundamental and applied biological sciences. Psychology Gene Expression - drug effects Humans Insulin Insulin - blood Insulin - physiology Insulin Receptor Substrate Proteins - metabolism Internal Medicine Obstetrics and Gynecology Placenta Placenta - drug effects Placenta - metabolism Pre-Eclampsia - blood Preeclampsia Pregnancy Syncytiotrophoblast Tissue Culture Techniques Tumor Necrosis Factor-alpha - pharmacology Water - metabolism
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