Ischemia-Induced Neural Stem/Progenitor Cells in the Pia Mater Following Cortical Infarction
Increasing evidence shows that neural stem/progenitor cells (NSPCs) can be activated in the nonconventional neurogenic zones such as the cortex following ischemic stroke. However, the precise origin, identity, and subtypes of the ischemia-induced NSPCs (iNSPCs), which can contribute to cortical neur...
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| Veröffentlicht in: | Stem cells and development 2011-12, Vol.20 (12), p.237-2051 |
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| creator | Nakagomi, Takayuki Molnár, Zoltán Nakano-Doi, Akiko Taguchi, Akihiko Saino, Orie Kubo, Shuji Clausen, Martijn Yoshikawa, Hiroo Nakagomi, Nami Matsuyama, Tomohiro |
| description | Increasing evidence shows that neural stem/progenitor cells (NSPCs) can be activated in the nonconventional neurogenic zones such as the cortex following ischemic stroke. However, the precise origin, identity, and subtypes of the ischemia-induced NSPCs (iNSPCs), which can contribute to cortical neurogenesis, is currently still unclear. In our present study, using an adult mouse cortical infarction model, we found that the leptomeninges (pia mater), which is widely distributed within and closely associated with blood vessels as microvascular pericytes/perivascular cells throughout central nervous system (CNS), have NSPC activity in response to ischemia and can generate neurons. These observations indicate that microvascular pericytes residing near blood vessels that are distributed from the leptomeninges to the cortex are potential sources of iNSPCs for neurogenesis following cortical infarction. In addition, our results propose a novel concept that the leptomeninges, which cover the entire brain, have an important role in CNS restoration following brain injury such as stroke. |
| doi_str_mv | 10.1089/scd.2011.0279 |
| format | Article |
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In addition, our results propose a novel concept that the leptomeninges, which cover the entire brain, have an important role in CNS restoration following brain injury such as stroke.</description><subject>Animals</subject><subject>Biomarkers - metabolism</subject><subject>Brain Infarction - complications</subject><subject>Brain Infarction - metabolism</subject><subject>Brain Infarction - pathology</subject><subject>Cell Proliferation</subject><subject>Cerebral Cortex - blood supply</subject><subject>Cerebral Cortex - metabolism</subject><subject>Cerebral Cortex - pathology</subject><subject>Intermediate Filament Proteins - metabolism</subject><subject>Male</subject><subject>Mice</subject><subject>Microvessels - metabolism</subject><subject>Microvessels - pathology</subject><subject>Models, Biological</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>Nestin</subject><subject>Neural Stem Cells - metabolism</subject><subject>Neural Stem Cells - pathology</subject><subject>Neurons - metabolism</subject><subject>Neurons - pathology</subject><subject>Pericytes - metabolism</subject><subject>Pericytes - pathology</subject><subject>Pia Mater - blood supply</subject><subject>Pia Mater - metabolism</subject><subject>Pia Mater - pathology</subject><subject>Rapid Communication</subject><subject>Stroke - complications</subject><subject>Stroke - metabolism</subject><subject>Stroke - pathology</subject><issn>1547-3287</issn><issn>1557-8534</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLxTAQRoMovpduJTtXvSaZtmmXcvFxwReoO6GkyVQjbaJJivjvbbnq1tUMw_k-hkPIEWcLzqr6NGqzEIzzBROy3iC7vChkVhWQb857LjMQldwhezG-MSZKUeXbZEfwCiam3CXPq6hfcbAqWzkzajT0FsegevqQcDi9D_4FnU0-0CX2faTW0fSK9N4qeqMSBnrh-95_WvdClz4kq6fkynUq6GS9OyBbneojHv7MffJ0cf64vMqu7y5Xy7PrTIMsUsalyDtjCp1DqRHKrgShgGNd8koUinetUMjaUorWQI0gO4C2QsVBcDC5gX1ysu59D_5jxJiawUY9Pawc-jE2NZMMSpB8IrM1qYOPMWDXvAc7qPDVcNbMPpvJZzP7bGafE3_80zy2A5o_-lfgBMAamM_Kud5iiyH9U_sNnbWB6w</recordid><startdate>20111201</startdate><enddate>20111201</enddate><creator>Nakagomi, Takayuki</creator><creator>Molnár, Zoltán</creator><creator>Nakano-Doi, Akiko</creator><creator>Taguchi, Akihiko</creator><creator>Saino, Orie</creator><creator>Kubo, Shuji</creator><creator>Clausen, Martijn</creator><creator>Yoshikawa, Hiroo</creator><creator>Nakagomi, Nami</creator><creator>Matsuyama, Tomohiro</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20111201</creationdate><title>Ischemia-Induced Neural Stem/Progenitor Cells in the Pia Mater Following Cortical Infarction</title><author>Nakagomi, Takayuki ; 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| subjects | Animals Biomarkers - metabolism Brain Infarction - complications Brain Infarction - metabolism Brain Infarction - pathology Cell Proliferation Cerebral Cortex - blood supply Cerebral Cortex - metabolism Cerebral Cortex - pathology Intermediate Filament Proteins - metabolism Male Mice Microvessels - metabolism Microvessels - pathology Models, Biological Nerve Tissue Proteins - metabolism Nestin Neural Stem Cells - metabolism Neural Stem Cells - pathology Neurons - metabolism Neurons - pathology Pericytes - metabolism Pericytes - pathology Pia Mater - blood supply Pia Mater - metabolism Pia Mater - pathology Rapid Communication Stroke - complications Stroke - metabolism Stroke - pathology |
| title | Ischemia-Induced Neural Stem/Progenitor Cells in the Pia Mater Following Cortical Infarction |
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