A pilot study of endothelial dysfunction and aortic stiffness after interleukin-6 receptor inhibition in rheumatoid arthritis

Interleukin (IL)-6 is a pleiotropic proinflammatory cytokine involved in the pathogenesis of both atherosclerosis and rheumatoid arthritis. The role of the IL-6/IL-6 receptor pathway in the documented acceleration of atherosclerosis in rheumatoid arthritis has not been examined. In a non-randomized...

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Veröffentlicht in:	Atherosclerosis 2011-12, Vol.219 (2), p.734-736
Hauptverfasser:	Protogerou, A.D, Zampeli, E, Fragiadaki, K, Stamatelopoulos, K, Papamichael, C, Sfikakis, P.P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibodies, Monoclonal, Humanized - administration & dosage Antibodies, Monoclonal, Humanized - therapeutic use Antirheumatic Agents - administration & dosage Antirheumatic Agents - therapeutic use Aorta - drug effects Aorta - immunology Aorta - physiopathology Arterial stiffness Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - immunology atherosclerosis Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular Diseases of the aorta Drug Administration Schedule Elasticity Endothelial function Endothelium, Vascular - drug effects Endothelium, Vascular - immunology Endothelium, Vascular - physiopathology Female Flow-mediated dilatation foot-and-mouth disease Greece Humans Infusions, Intravenous Interleukin-6 Medical sciences Middle Aged pathogenesis Pilot Projects Prospective Studies Pulsatile Flow - drug effects Pulse wave velocity Receptors, Interleukin-6 - antagonists & inhibitors Receptors, Interleukin-6 - immunology Rheumatoid arthritis Time Factors Tocilizumab Treatment Outcome Vasodilation - drug effects
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