Thermosensitive hydrogel for prolonged delivery of lentiviral vector expressing neurotrophin-3 in vitro

Background The development of tissue engineering scaffolds for gene delivery has the potential to enhance gene transfer efficiency and safety via controlled temporal and spatial delivery. Lentiviral delivery can be carried out using the natural biopolymer thermoresponsive gel, chitosan/β‐glycerol ph...

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Veröffentlicht in:	The journal of gene medicine 2011-11, Vol.13 (11), p.591-601
Hauptverfasser:	McMahon, Siobhan S, Nikolskaya, Natalia, Choileáin, Siobhan Ní, Hennessy, Niamh, O'Brien, Timothy, Strappe, Padraig M, Gorelov, Alexander, Rochev, Yury
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axonogenesis Biopolymers Cell culture chitosan Chitosan - chemistry Collagen Collagen - chemistry Culture Media - chemistry Dorsal root ganglia Embryo, Mammalian - cytology Embryo, Mammalian - metabolism Expression vectors Flow Cytometry Ganglia, Spinal - cytology Ganglia, Spinal - embryology Ganglia, Spinal - metabolism Gelation Gene Expression Profiling Gene therapy Gene transfer Gene Transfer Techniques Genetic Vectors - genetics Genetic Vectors - metabolism Glycerophosphates - chemistry Green fluorescent protein Green Fluorescent Proteins - metabolism HeLa Cells Humans hydrogels Hydrogels - chemistry Hydrogen-Ion Concentration Injuries lentiviral vector Lentivirus - genetics Lentivirus - metabolism Nervous system Neurites - metabolism Neurotrophin 3 Neurotrophin 3 - metabolism pH effects Phosphate Rats Rats, Sprague-Dawley scaffolds Temperature Temperature effects Time Factors Tissue Engineering Tissue Scaffolds
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