Validation of the CKD-EPI formula in patients after renal transplantation
Background. Accurate calculation of glomerular filtration rate (GFR) is crucial in the management of patients after kidney transplantation (KTx). Recently, the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula was introduced to estimate GFR in chronic kidney disease patients. Howev...
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| Veröffentlicht in: | Nephrology, dialysis, transplantation dialysis, transplantation, 2011-12, Vol.26 (12), p.4104-4108 |
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| creator | Pöge, Uwe Gerhardt, Thomas Stoffel-Wagner, Birgit Sauerbruch, Tilman Woitas, Rainer P. |
| description | Background. Accurate calculation of glomerular filtration rate (GFR) is crucial in the management of patients after kidney transplantation (KTx). Recently, the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula was introduced to estimate GFR in chronic kidney disease patients. However, to date the diagnostic value of this equation remains to be determined in patients after KTx.
Methods. We analysed the CKD-EPI formula in comparison to the re-expressed Modification of Diet in Renal Disease (MDRD) equation in 170 stable patients after renal transplantation. Correlation, bias, precision and accuracy within 30 and 50% of true GFR were determined. GFR was measured by technetium-diethylenetriamine pentaacetic acid clearance [39.6, 95% confidence interval (CI): 37.3-42.0 mL/min/1.73m2].
Results. The results for the MDRD and CKD-EPI equations correlated well with GFR (0.82; 0.83, respectively). GFR calculated by MDRD (44.1, 95% CI: 41.6-46.8 mL/min/1.73m2) and CKD-EPI (47.7, 95% CI: 44.7-50.7 mL/min/1.73m2) overestimated true GFR significantly (P < 0.001). Precision was not significantly different between MDRD and CKD-EPI (10.9 versus 10.0 mL/min/1.73m2, respectively). Accuracy within 30% of true GFR was significantly higher for MDRD (71.8%) than for CKD-EPI (64.1%, P = 0.0014). Accuracy within 50% of true GFR did not differ significantly (MDRD: 89.4% versus CKD-EPI: 84.7%, P = 0.06).
Conclusion. The new CKD-EPI formula did not improve the estimation of GFR in Caucasian patients after renal transplantation in this study. |
| doi_str_mv | 10.1093/ndt/gfr183 |
| format | Article |
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Methods. We analysed the CKD-EPI formula in comparison to the re-expressed Modification of Diet in Renal Disease (MDRD) equation in 170 stable patients after renal transplantation. Correlation, bias, precision and accuracy within 30 and 50% of true GFR were determined. GFR was measured by technetium-diethylenetriamine pentaacetic acid clearance [39.6, 95% confidence interval (CI): 37.3-42.0 mL/min/1.73m2].
Results. The results for the MDRD and CKD-EPI equations correlated well with GFR (0.82; 0.83, respectively). GFR calculated by MDRD (44.1, 95% CI: 41.6-46.8 mL/min/1.73m2) and CKD-EPI (47.7, 95% CI: 44.7-50.7 mL/min/1.73m2) overestimated true GFR significantly (P < 0.001). Precision was not significantly different between MDRD and CKD-EPI (10.9 versus 10.0 mL/min/1.73m2, respectively). Accuracy within 30% of true GFR was significantly higher for MDRD (71.8%) than for CKD-EPI (64.1%, P = 0.0014). Accuracy within 50% of true GFR did not differ significantly (MDRD: 89.4% versus CKD-EPI: 84.7%, P = 0.06).
Conclusion. The new CKD-EPI formula did not improve the estimation of GFR in Caucasian patients after renal transplantation in this study.</description><identifier>ISSN: 0931-0509</identifier><identifier>EISSN: 1460-2385</identifier><identifier>DOI: 10.1093/ndt/gfr183</identifier><identifier>PMID: 21551088</identifier><identifier>CODEN: NDTREA</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Emergency and intensive care: renal failure. Dialysis management ; Female ; Glomerular Filtration Rate ; Humans ; Intensive care medicine ; Kidney Function Tests - methods ; Kidney Function Tests - standards ; Kidney Transplantation - physiology ; Male ; Medical sciences ; Middle Aged ; Prospective Studies ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the urinary system</subject><ispartof>Nephrology, dialysis, transplantation, 2011-12, Vol.26 (12), p.4104-4108</ispartof><rights>The Author 2011. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com 2011</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c346t-4dc88d85cf688ea37fab096d3cd9f37d3ccfb9f8f2e5f1b0ea5caf7b346825493</citedby><cites>FETCH-LOGICAL-c346t-4dc88d85cf688ea37fab096d3cd9f37d3ccfb9f8f2e5f1b0ea5caf7b346825493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,1585,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25330660$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21551088$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pöge, Uwe</creatorcontrib><creatorcontrib>Gerhardt, Thomas</creatorcontrib><creatorcontrib>Stoffel-Wagner, Birgit</creatorcontrib><creatorcontrib>Sauerbruch, Tilman</creatorcontrib><creatorcontrib>Woitas, Rainer P.</creatorcontrib><title>Validation of the CKD-EPI formula in patients after renal transplantation</title><title>Nephrology, dialysis, transplantation</title><addtitle>Nephrol Dial Transplant</addtitle><description>Background. Accurate calculation of glomerular filtration rate (GFR) is crucial in the management of patients after kidney transplantation (KTx). Recently, the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula was introduced to estimate GFR in chronic kidney disease patients. However, to date the diagnostic value of this equation remains to be determined in patients after KTx.
Methods. We analysed the CKD-EPI formula in comparison to the re-expressed Modification of Diet in Renal Disease (MDRD) equation in 170 stable patients after renal transplantation. Correlation, bias, precision and accuracy within 30 and 50% of true GFR were determined. GFR was measured by technetium-diethylenetriamine pentaacetic acid clearance [39.6, 95% confidence interval (CI): 37.3-42.0 mL/min/1.73m2].
Results. The results for the MDRD and CKD-EPI equations correlated well with GFR (0.82; 0.83, respectively). GFR calculated by MDRD (44.1, 95% CI: 41.6-46.8 mL/min/1.73m2) and CKD-EPI (47.7, 95% CI: 44.7-50.7 mL/min/1.73m2) overestimated true GFR significantly (P < 0.001). Precision was not significantly different between MDRD and CKD-EPI (10.9 versus 10.0 mL/min/1.73m2, respectively). Accuracy within 30% of true GFR was significantly higher for MDRD (71.8%) than for CKD-EPI (64.1%, P = 0.0014). Accuracy within 50% of true GFR did not differ significantly (MDRD: 89.4% versus CKD-EPI: 84.7%, P = 0.06).
Conclusion. The new CKD-EPI formula did not improve the estimation of GFR in Caucasian patients after renal transplantation in this study.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Emergency and intensive care: renal failure. Dialysis management</subject><subject>Female</subject><subject>Glomerular Filtration Rate</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Kidney Function Tests - methods</subject><subject>Kidney Function Tests - standards</subject><subject>Kidney Transplantation - physiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the urinary system</subject><issn>0931-0509</issn><issn>1460-2385</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90D1PwzAQBmALgWgpLPwA5AUhIYWe49ixR1QKVFSCAVgjx7EhKF_YzsC_x9ACG9MN99zZ9yJ0TOCCgKTzrgrzF-uIoDtoSjIOSUoF20XT2CQJMJATdOD9GwDINM_30SQljBEQYopWz6qpKxXqvsO9xeHV4MXdVbJ8WGHbu3ZsFK47PERguuCxssE47EynGhyc6vzQqC58jx-iPasab462dYaerpePi9tkfX-zWlyuE00zHpKs0kJUgmnLhTCK5laVIHlFdSUtzWPVtpRW2NQwS0owimll8zIOi5Rlks7Q2Wbv4Pr30fhQtLXXpokfMf3oCwmc8Xgcj_J8I7XrvXfGFoOrW-U-CgLFV3JFTK7YJBfxyXbtWLam-qU_UUVwugXKa9XYeL2u_Z9jlALn8Of6cfjvwU-bdYRI</recordid><startdate>20111201</startdate><enddate>20111201</enddate><creator>Pöge, Uwe</creator><creator>Gerhardt, Thomas</creator><creator>Stoffel-Wagner, Birgit</creator><creator>Sauerbruch, Tilman</creator><creator>Woitas, Rainer P.</creator><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20111201</creationdate><title>Validation of the CKD-EPI formula in patients after renal transplantation</title><author>Pöge, Uwe ; Gerhardt, Thomas ; Stoffel-Wagner, Birgit ; Sauerbruch, Tilman ; Woitas, Rainer P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c346t-4dc88d85cf688ea37fab096d3cd9f37d3ccfb9f8f2e5f1b0ea5caf7b346825493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Emergency and intensive care: renal failure. Dialysis management</topic><topic>Female</topic><topic>Glomerular Filtration Rate</topic><topic>Humans</topic><topic>Intensive care medicine</topic><topic>Kidney Function Tests - methods</topic><topic>Kidney Function Tests - standards</topic><topic>Kidney Transplantation - physiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Prospective Studies</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the urinary system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pöge, Uwe</creatorcontrib><creatorcontrib>Gerhardt, Thomas</creatorcontrib><creatorcontrib>Stoffel-Wagner, Birgit</creatorcontrib><creatorcontrib>Sauerbruch, Tilman</creatorcontrib><creatorcontrib>Woitas, Rainer P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nephrology, dialysis, transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pöge, Uwe</au><au>Gerhardt, Thomas</au><au>Stoffel-Wagner, Birgit</au><au>Sauerbruch, Tilman</au><au>Woitas, Rainer P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Validation of the CKD-EPI formula in patients after renal transplantation</atitle><jtitle>Nephrology, dialysis, transplantation</jtitle><addtitle>Nephrol Dial Transplant</addtitle><date>2011-12-01</date><risdate>2011</risdate><volume>26</volume><issue>12</issue><spage>4104</spage><epage>4108</epage><pages>4104-4108</pages><issn>0931-0509</issn><eissn>1460-2385</eissn><coden>NDTREA</coden><abstract>Background. Accurate calculation of glomerular filtration rate (GFR) is crucial in the management of patients after kidney transplantation (KTx). Recently, the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula was introduced to estimate GFR in chronic kidney disease patients. However, to date the diagnostic value of this equation remains to be determined in patients after KTx.
Methods. We analysed the CKD-EPI formula in comparison to the re-expressed Modification of Diet in Renal Disease (MDRD) equation in 170 stable patients after renal transplantation. Correlation, bias, precision and accuracy within 30 and 50% of true GFR were determined. GFR was measured by technetium-diethylenetriamine pentaacetic acid clearance [39.6, 95% confidence interval (CI): 37.3-42.0 mL/min/1.73m2].
Results. The results for the MDRD and CKD-EPI equations correlated well with GFR (0.82; 0.83, respectively). GFR calculated by MDRD (44.1, 95% CI: 41.6-46.8 mL/min/1.73m2) and CKD-EPI (47.7, 95% CI: 44.7-50.7 mL/min/1.73m2) overestimated true GFR significantly (P < 0.001). Precision was not significantly different between MDRD and CKD-EPI (10.9 versus 10.0 mL/min/1.73m2, respectively). Accuracy within 30% of true GFR was significantly higher for MDRD (71.8%) than for CKD-EPI (64.1%, P = 0.0014). Accuracy within 50% of true GFR did not differ significantly (MDRD: 89.4% versus CKD-EPI: 84.7%, P = 0.06).
Conclusion. The new CKD-EPI formula did not improve the estimation of GFR in Caucasian patients after renal transplantation in this study.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>21551088</pmid><doi>10.1093/ndt/gfr183</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Emergency and intensive care: renal failure. Dialysis management Female Glomerular Filtration Rate Humans Intensive care medicine Kidney Function Tests - methods Kidney Function Tests - standards Kidney Transplantation - physiology Male Medical sciences Middle Aged Prospective Studies Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the urinary system |
| title | Validation of the CKD-EPI formula in patients after renal transplantation |
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