High-frequency electromagnetic dynamics properties of THP1 cells using scanning microwave microscopy
Microwave measurements combined with scanning probe microscopy is a novel tool to explore high-localized mechanical and electrical properties of biological species. Complex permittivities and permeabilities are detected through slight variations of an incident microwave signal. Here we report the hi...
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| Veröffentlicht in: | Ultramicroscopy 2011-11, Vol.111 (11), p.1625-1629 |
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| container_title | Ultramicroscopy |
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| creator | Oh, Yoo Jin Huber, Hans-Peter Hochleitner, Markus Duman, Memed Bozna, Bianca Kastner, Markus Kienberger, Ferry Hinterdorfer, Peter |
| description | Microwave measurements combined with scanning probe microscopy is a novel tool to explore high-localized mechanical and electrical properties of biological species. Complex permittivities and permeabilities are detected through slight variations of an incident microwave signal. Here we report the high-frequency dependence of the electromagnetic dynamic characteristics in human monocytic leukemia cells (THP1) through local measurements by scanning microwave microscopy (SMM). The amplitude and phase images were shown to depend on the applied resonance frequency. While the amplitude yields information about the resistivity determined by the water and the ionic strength, the phase information reflects the dielectric losses arising from the fluid density.
► Experimental results of scanning microwave microscopy applied to biological cells. ► Electromagnetic dynamic characteristics in THP1 cell by SMM. ► Sub-micron spatial topographical image of the cellular surface. ► Information from underneath the cell surface collected in microwave images. ► Variations in the dielectric properties of cells at different resonant frequencies. |
| doi_str_mv | 10.1016/j.ultramic.2011.09.005 |
| format | Article |
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► Experimental results of scanning microwave microscopy applied to biological cells. ► Electromagnetic dynamic characteristics in THP1 cell by SMM. ► Sub-micron spatial topographical image of the cellular surface. ► Information from underneath the cell surface collected in microwave images. ► Variations in the dielectric properties of cells at different resonant frequencies.</description><identifier>ISSN: 0304-3991</identifier><identifier>EISSN: 1879-2723</identifier><identifier>DOI: 10.1016/j.ultramic.2011.09.005</identifier><identifier>PMID: 21963779</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>AFM ; Amplitudes ; Biological cell ; Cell Line, Tumor ; Complex permittivity ; Density ; Dielectric loss ; Electromagnetic Phenomena ; Humans ; Microscopy ; Microscopy, Scanning Probe - methods ; Microwaves ; Near-field microwave ; Neoplasms - pathology ; Scanning ; Scanning microwave microscopy</subject><ispartof>Ultramicroscopy, 2011-11, Vol.111 (11), p.1625-1629</ispartof><rights>2011 Elsevier B.V.</rights><rights>Copyright © 2011 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c466t-219a304cf15c128f6ee345e9cf1dfd2604be61692dedd5456a584e398c4796453</citedby><cites>FETCH-LOGICAL-c466t-219a304cf15c128f6ee345e9cf1dfd2604be61692dedd5456a584e398c4796453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ultramic.2011.09.005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21963779$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oh, Yoo Jin</creatorcontrib><creatorcontrib>Huber, Hans-Peter</creatorcontrib><creatorcontrib>Hochleitner, Markus</creatorcontrib><creatorcontrib>Duman, Memed</creatorcontrib><creatorcontrib>Bozna, Bianca</creatorcontrib><creatorcontrib>Kastner, Markus</creatorcontrib><creatorcontrib>Kienberger, Ferry</creatorcontrib><creatorcontrib>Hinterdorfer, Peter</creatorcontrib><title>High-frequency electromagnetic dynamics properties of THP1 cells using scanning microwave microscopy</title><title>Ultramicroscopy</title><addtitle>Ultramicroscopy</addtitle><description>Microwave measurements combined with scanning probe microscopy is a novel tool to explore high-localized mechanical and electrical properties of biological species. Complex permittivities and permeabilities are detected through slight variations of an incident microwave signal. Here we report the high-frequency dependence of the electromagnetic dynamic characteristics in human monocytic leukemia cells (THP1) through local measurements by scanning microwave microscopy (SMM). The amplitude and phase images were shown to depend on the applied resonance frequency. While the amplitude yields information about the resistivity determined by the water and the ionic strength, the phase information reflects the dielectric losses arising from the fluid density.
► Experimental results of scanning microwave microscopy applied to biological cells. ► Electromagnetic dynamic characteristics in THP1 cell by SMM. ► Sub-micron spatial topographical image of the cellular surface. ► Information from underneath the cell surface collected in microwave images. ► Variations in the dielectric properties of cells at different resonant frequencies.</description><subject>AFM</subject><subject>Amplitudes</subject><subject>Biological cell</subject><subject>Cell Line, Tumor</subject><subject>Complex permittivity</subject><subject>Density</subject><subject>Dielectric loss</subject><subject>Electromagnetic Phenomena</subject><subject>Humans</subject><subject>Microscopy</subject><subject>Microscopy, Scanning Probe - methods</subject><subject>Microwaves</subject><subject>Near-field microwave</subject><subject>Neoplasms - pathology</subject><subject>Scanning</subject><subject>Scanning microwave microscopy</subject><issn>0304-3991</issn><issn>1879-2723</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi1ERZfCX6hyg0vCTPyR-AaqKFupEj2Us-Xak8WrfCx2UrT_vo625UhPHlnPzPvOvIxdIlQIqL7sq6Wfox2Cq2pArEBXAPIN22Db6LJuav6WbYCDKLnWeM7ep7QHAATRvmPnNWrFm0ZvmN-G3e-yi_RnodEdC-rJzXEa7G6kObjCH8dVJBWHOB0ozoFSMXXF_fYOC0d9n4olhXFXJGfHcS0yHKe_9pFOVXLT4fiBnXW2T_Tx-b1gv66_319ty9ufP26uvt2WTig1l9mVzY5dh9Jh3XaKiAtJOn_4ztcKxAMpVLr25L0UUlnZCuK6daLRSkh-wT6d5mazeZ80myGk1aUdaVqS0aCkgqZdyc__JVE1yCXytsmoOqHrNilSZw4xDDYeDYJZszB785KFWbMwoE3OIjdePmssDwP5f20vx8_A1xNA-SaPgaJJLuQUyIeYUzB-Cq9pPAEOkJ96</recordid><startdate>20111101</startdate><enddate>20111101</enddate><creator>Oh, Yoo Jin</creator><creator>Huber, Hans-Peter</creator><creator>Hochleitner, Markus</creator><creator>Duman, Memed</creator><creator>Bozna, Bianca</creator><creator>Kastner, Markus</creator><creator>Kienberger, Ferry</creator><creator>Hinterdorfer, Peter</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>20111101</creationdate><title>High-frequency electromagnetic dynamics properties of THP1 cells using scanning microwave microscopy</title><author>Oh, Yoo Jin ; Huber, Hans-Peter ; Hochleitner, Markus ; Duman, Memed ; Bozna, Bianca ; Kastner, Markus ; Kienberger, Ferry ; Hinterdorfer, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c466t-219a304cf15c128f6ee345e9cf1dfd2604be61692dedd5456a584e398c4796453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>AFM</topic><topic>Amplitudes</topic><topic>Biological cell</topic><topic>Cell Line, Tumor</topic><topic>Complex permittivity</topic><topic>Density</topic><topic>Dielectric loss</topic><topic>Electromagnetic Phenomena</topic><topic>Humans</topic><topic>Microscopy</topic><topic>Microscopy, Scanning Probe - methods</topic><topic>Microwaves</topic><topic>Near-field microwave</topic><topic>Neoplasms - pathology</topic><topic>Scanning</topic><topic>Scanning microwave microscopy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oh, Yoo Jin</creatorcontrib><creatorcontrib>Huber, Hans-Peter</creatorcontrib><creatorcontrib>Hochleitner, Markus</creatorcontrib><creatorcontrib>Duman, Memed</creatorcontrib><creatorcontrib>Bozna, Bianca</creatorcontrib><creatorcontrib>Kastner, Markus</creatorcontrib><creatorcontrib>Kienberger, Ferry</creatorcontrib><creatorcontrib>Hinterdorfer, Peter</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Ultramicroscopy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oh, Yoo Jin</au><au>Huber, Hans-Peter</au><au>Hochleitner, Markus</au><au>Duman, Memed</au><au>Bozna, Bianca</au><au>Kastner, Markus</au><au>Kienberger, Ferry</au><au>Hinterdorfer, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High-frequency electromagnetic dynamics properties of THP1 cells using scanning microwave microscopy</atitle><jtitle>Ultramicroscopy</jtitle><addtitle>Ultramicroscopy</addtitle><date>2011-11-01</date><risdate>2011</risdate><volume>111</volume><issue>11</issue><spage>1625</spage><epage>1629</epage><pages>1625-1629</pages><issn>0304-3991</issn><eissn>1879-2723</eissn><abstract>Microwave measurements combined with scanning probe microscopy is a novel tool to explore high-localized mechanical and electrical properties of biological species. Complex permittivities and permeabilities are detected through slight variations of an incident microwave signal. Here we report the high-frequency dependence of the electromagnetic dynamic characteristics in human monocytic leukemia cells (THP1) through local measurements by scanning microwave microscopy (SMM). The amplitude and phase images were shown to depend on the applied resonance frequency. While the amplitude yields information about the resistivity determined by the water and the ionic strength, the phase information reflects the dielectric losses arising from the fluid density.
► Experimental results of scanning microwave microscopy applied to biological cells. ► Electromagnetic dynamic characteristics in THP1 cell by SMM. ► Sub-micron spatial topographical image of the cellular surface. ► Information from underneath the cell surface collected in microwave images. ► Variations in the dielectric properties of cells at different resonant frequencies.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>21963779</pmid><doi>10.1016/j.ultramic.2011.09.005</doi><tpages>5</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | AFM Amplitudes Biological cell Cell Line, Tumor Complex permittivity Density Dielectric loss Electromagnetic Phenomena Humans Microscopy Microscopy, Scanning Probe - methods Microwaves Near-field microwave Neoplasms - pathology Scanning Scanning microwave microscopy |
| title | High-frequency electromagnetic dynamics properties of THP1 cells using scanning microwave microscopy |
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