Effect of Small Interfering RNA Targeting Wild-Type FLT3 in Acute Myeloid Leukaemia Cells In Vitro and In Vivo

This study investigated the effect of using small interfering RNA (siRNA) to silence the wild-type FMS-like tyrosine kinase 3 (FLT3) gene in acute myeloid leukaemia (AML) cells, in vitro and in vivo. FLT3 siRNA was introduced into the human AML cell line, THP1, and into a THP1 xenograft tumour model...

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Veröffentlicht in:	Journal of international medical research 2011-10, Vol.39 (5), p.1661-1674
Hauptverfasser:	Wang, C-M, Sheng, G-Y, Lu, J, Xie, L, Bai, S-T, Xu, X-J, Liu, Y-F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Cell Line, Tumor Cell Proliferation Cyclin D1 - metabolism fms-Like Tyrosine Kinase 3 - genetics fms-Like Tyrosine Kinase 3 - metabolism Gene Expression Gene Knockdown Techniques Humans Leukemia, Myeloid, Acute - enzymology Leukemia, Myeloid, Acute - pathology Male Mice Mice, Inbred BALB C Mice, Nude Neoplasm Transplantation Nuclear Receptor Co-Repressor 2 - metabolism Proto-Oncogene Proteins c-bcl-2 - metabolism RNA Interference RNA, Small Interfering - genetics RNA, Small Interfering - pharmacology Tumor Burden
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