Synthesis of α,α-Disubstituted α-Amino Esters: Nucleophilic Addition to Iminium Salts Generated from Amino Ketene Silyl Acetals

Alkoxycarbonyl iminium species are prepared easily by the oxidation of tetrasubstituted amino ketene silyl acetals, and subsequent nucleophilic addition of Grignard reagents to the iminium salts gives α,α-disubstituted α-amino ester derivatives in moderate to good yields, in which aryl and ethynyl s...

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Veröffentlicht in:	Journal of organic chemistry 2011-12, Vol.76 (23), p.9670-9677
Hauptverfasser:	Hata, Shingo, Koyama, Hiroshi, Shimizu, Makoto
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetals - chemistry Esters - chemical synthesis Esters - chemistry Ethylenes - chemistry Imines - chemical synthesis Imines - chemistry Ketones - chemistry Molecular Structure Salts - chemical synthesis Salts - chemistry
Online-Zugang:	Volltext
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