Common iliac vein stenosis: a risk factor for oral contraceptive-induced deep vein thrombosis
Objective The objective of the study was to determine whether women with significant left common iliac vein stenosis who also use combined oral contraceptives (COCs) have a combined likelihood of deep vein thrombosis (DVT) greater than each independent risk. Study Design This was a case-control stud...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 2011-12, Vol.205 (6), p.537.e1-537.e6 |
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| container_title | American journal of obstetrics and gynecology |
| container_volume | 205 |
| creator | Chan, Keith T., MD Tye, Grace A., MD Popat, Rita A., PhD Kuo, William T., MD Unver, Kamil, MBiomedE Kothary, Nishita, MD Sze, Daniel Y., MD, PhD Hofmann, Lawrence V., MD |
| description | Objective The objective of the study was to determine whether women with significant left common iliac vein stenosis who also use combined oral contraceptives (COCs) have a combined likelihood of deep vein thrombosis (DVT) greater than each independent risk. Study Design This was a case-control study comparing 35 women with DVT against 35 age-matched controls. Common iliac vein diameters were measured from computed tomography and magnetic resonance imaging. Logistic regression modeling was used with adjustment for risk factors. Results DVT was associated with COC use ( P = .022) and with increasing degrees of common iliac vein stenosis ( P = .004). Compared with women without venous stenosis or COC use, the odds of DVT in women with a 70% venous stenosis who also use COCs was associated with a 17-fold increase ( P = .01). Conclusion Venous stenosis and COC use are independent risk factors for DVT. Women concurrently exposed to both have a multiplicative effect resulting in an increased risk of DVT. We recommend further studies to investigate this effect and its potential clinical implications. |
| doi_str_mv | 10.1016/j.ajog.2011.06.100 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_906154389</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0002937811008957</els_id><sourcerecordid>906154389</sourcerecordid><originalsourceid>FETCH-LOGICAL-c440t-4ccd2d7cb03aeac53c98e83a19e68d38420731a35bdb9ccea55609c38032410e3</originalsourceid><addsrcrecordid>eNp9kUurFDEQhYMo3nH0D7iQ3oirHitJPxKRCzL4ggsu1KWEdHW1Zm53MibdA_ffm2ZGBRcuQpHinJPUV4w95bDjwJuXh509hO87AZzvoMk9uMc2HHRbNqpR99kGAESpZauu2KOUDutVaPGQXQmutJSgNuzbPkxT8IUbncXiRM4XaSYfkkuvCltEl26LweIcYjHkE6IdCwx-jhbpOLsTlc73C1Jf9ETHc8D8I4apWyMesweDHRM9udQt-_ru7Zf9h_Lm0_uP-zc3JVYVzGWF2Iu-xQ6kJYu1RK1IScs1NaqXqhLQSm5l3fWdRiRb1w1olAqkqDiQ3LIX59xjDD8XSrOZXEIaR-spLMloaHhdyTz0lomzEmNIKdJgjtFNNt4ZDmalag5mpWpWqgaa3INsenaJX7qJ-j-W3xiz4PlFYBPacYjWo0t_dbXQsgKeda_POsowTo6iSejIZ3wuEs6mD-7__7j-x46j8y6_eEt3lA5hiT5jNtwkYcB8Xhe-rp9ns9J1K38BvLGq1g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>906154389</pqid></control><display><type>article</type><title>Common iliac vein stenosis: a risk factor for oral contraceptive-induced deep vein thrombosis</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Chan, Keith T., MD ; Tye, Grace A., MD ; Popat, Rita A., PhD ; Kuo, William T., MD ; Unver, Kamil, MBiomedE ; Kothary, Nishita, MD ; Sze, Daniel Y., MD, PhD ; Hofmann, Lawrence V., MD</creator><creatorcontrib>Chan, Keith T., MD ; Tye, Grace A., MD ; Popat, Rita A., PhD ; Kuo, William T., MD ; Unver, Kamil, MBiomedE ; Kothary, Nishita, MD ; Sze, Daniel Y., MD, PhD ; Hofmann, Lawrence V., MD</creatorcontrib><description>Objective The objective of the study was to determine whether women with significant left common iliac vein stenosis who also use combined oral contraceptives (COCs) have a combined likelihood of deep vein thrombosis (DVT) greater than each independent risk. Study Design This was a case-control study comparing 35 women with DVT against 35 age-matched controls. Common iliac vein diameters were measured from computed tomography and magnetic resonance imaging. Logistic regression modeling was used with adjustment for risk factors. Results DVT was associated with COC use ( P = .022) and with increasing degrees of common iliac vein stenosis ( P = .004). Compared with women without venous stenosis or COC use, the odds of DVT in women with a 70% venous stenosis who also use COCs was associated with a 17-fold increase ( P = .01). Conclusion Venous stenosis and COC use are independent risk factors for DVT. Women concurrently exposed to both have a multiplicative effect resulting in an increased risk of DVT. We recommend further studies to investigate this effect and its potential clinical implications.</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/j.ajog.2011.06.100</identifier><identifier>PMID: 21893308</identifier><identifier>CODEN: AJOGAH</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Case-Control Studies ; Constriction, Pathologic - chemically induced ; Constriction, Pathologic - epidemiology ; Constriction, Pathologic - pathology ; Contraceptives, Oral - adverse effects ; deep vein thrombosis ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; iliac vein ; Iliac Vein - pathology ; Logistic Models ; Magnetic Resonance Imaging ; Medical sciences ; Middle Aged ; Multivariate Analysis ; Obstetrics and Gynecology ; oral contraceptive ; Retrospective Studies ; Risk Factors ; Tomography, X-Ray Computed ; venous stenosis ; Venous Thrombosis - chemically induced ; Venous Thrombosis - epidemiology ; Venous Thrombosis - pathology ; Young Adult</subject><ispartof>American journal of obstetrics and gynecology, 2011-12, Vol.205 (6), p.537.e1-537.e6</ispartof><rights>Mosby, Inc.</rights><rights>2011 Mosby, Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Mosby, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-4ccd2d7cb03aeac53c98e83a19e68d38420731a35bdb9ccea55609c38032410e3</citedby><cites>FETCH-LOGICAL-c440t-4ccd2d7cb03aeac53c98e83a19e68d38420731a35bdb9ccea55609c38032410e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ajog.2011.06.100$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25293401$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21893308$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chan, Keith T., MD</creatorcontrib><creatorcontrib>Tye, Grace A., MD</creatorcontrib><creatorcontrib>Popat, Rita A., PhD</creatorcontrib><creatorcontrib>Kuo, William T., MD</creatorcontrib><creatorcontrib>Unver, Kamil, MBiomedE</creatorcontrib><creatorcontrib>Kothary, Nishita, MD</creatorcontrib><creatorcontrib>Sze, Daniel Y., MD, PhD</creatorcontrib><creatorcontrib>Hofmann, Lawrence V., MD</creatorcontrib><title>Common iliac vein stenosis: a risk factor for oral contraceptive-induced deep vein thrombosis</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>Objective The objective of the study was to determine whether women with significant left common iliac vein stenosis who also use combined oral contraceptives (COCs) have a combined likelihood of deep vein thrombosis (DVT) greater than each independent risk. Study Design This was a case-control study comparing 35 women with DVT against 35 age-matched controls. Common iliac vein diameters were measured from computed tomography and magnetic resonance imaging. Logistic regression modeling was used with adjustment for risk factors. Results DVT was associated with COC use ( P = .022) and with increasing degrees of common iliac vein stenosis ( P = .004). Compared with women without venous stenosis or COC use, the odds of DVT in women with a 70% venous stenosis who also use COCs was associated with a 17-fold increase ( P = .01). Conclusion Venous stenosis and COC use are independent risk factors for DVT. Women concurrently exposed to both have a multiplicative effect resulting in an increased risk of DVT. We recommend further studies to investigate this effect and its potential clinical implications.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Case-Control Studies</subject><subject>Constriction, Pathologic - chemically induced</subject><subject>Constriction, Pathologic - epidemiology</subject><subject>Constriction, Pathologic - pathology</subject><subject>Contraceptives, Oral - adverse effects</subject><subject>deep vein thrombosis</subject><subject>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>iliac vein</subject><subject>Iliac Vein - pathology</subject><subject>Logistic Models</subject><subject>Magnetic Resonance Imaging</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Obstetrics and Gynecology</subject><subject>oral contraceptive</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Tomography, X-Ray Computed</subject><subject>venous stenosis</subject><subject>Venous Thrombosis - chemically induced</subject><subject>Venous Thrombosis - epidemiology</subject><subject>Venous Thrombosis - pathology</subject><subject>Young Adult</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUurFDEQhYMo3nH0D7iQ3oirHitJPxKRCzL4ggsu1KWEdHW1Zm53MibdA_ffm2ZGBRcuQpHinJPUV4w95bDjwJuXh509hO87AZzvoMk9uMc2HHRbNqpR99kGAESpZauu2KOUDutVaPGQXQmutJSgNuzbPkxT8IUbncXiRM4XaSYfkkuvCltEl26LweIcYjHkE6IdCwx-jhbpOLsTlc73C1Jf9ETHc8D8I4apWyMesweDHRM9udQt-_ru7Zf9h_Lm0_uP-zc3JVYVzGWF2Iu-xQ6kJYu1RK1IScs1NaqXqhLQSm5l3fWdRiRb1w1olAqkqDiQ3LIX59xjDD8XSrOZXEIaR-spLMloaHhdyTz0lomzEmNIKdJgjtFNNt4ZDmalag5mpWpWqgaa3INsenaJX7qJ-j-W3xiz4PlFYBPacYjWo0t_dbXQsgKeda_POsowTo6iSejIZ3wuEs6mD-7__7j-x46j8y6_eEt3lA5hiT5jNtwkYcB8Xhe-rp9ns9J1K38BvLGq1g</recordid><startdate>20111201</startdate><enddate>20111201</enddate><creator>Chan, Keith T., MD</creator><creator>Tye, Grace A., MD</creator><creator>Popat, Rita A., PhD</creator><creator>Kuo, William T., MD</creator><creator>Unver, Kamil, MBiomedE</creator><creator>Kothary, Nishita, MD</creator><creator>Sze, Daniel Y., MD, PhD</creator><creator>Hofmann, Lawrence V., MD</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20111201</creationdate><title>Common iliac vein stenosis: a risk factor for oral contraceptive-induced deep vein thrombosis</title><author>Chan, Keith T., MD ; Tye, Grace A., MD ; Popat, Rita A., PhD ; Kuo, William T., MD ; Unver, Kamil, MBiomedE ; Kothary, Nishita, MD ; Sze, Daniel Y., MD, PhD ; Hofmann, Lawrence V., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c440t-4ccd2d7cb03aeac53c98e83a19e68d38420731a35bdb9ccea55609c38032410e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Case-Control Studies</topic><topic>Constriction, Pathologic - chemically induced</topic><topic>Constriction, Pathologic - epidemiology</topic><topic>Constriction, Pathologic - pathology</topic><topic>Contraceptives, Oral - adverse effects</topic><topic>deep vein thrombosis</topic><topic>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>iliac vein</topic><topic>Iliac Vein - pathology</topic><topic>Logistic Models</topic><topic>Magnetic Resonance Imaging</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Obstetrics and Gynecology</topic><topic>oral contraceptive</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Tomography, X-Ray Computed</topic><topic>venous stenosis</topic><topic>Venous Thrombosis - chemically induced</topic><topic>Venous Thrombosis - epidemiology</topic><topic>Venous Thrombosis - pathology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chan, Keith T., MD</creatorcontrib><creatorcontrib>Tye, Grace A., MD</creatorcontrib><creatorcontrib>Popat, Rita A., PhD</creatorcontrib><creatorcontrib>Kuo, William T., MD</creatorcontrib><creatorcontrib>Unver, Kamil, MBiomedE</creatorcontrib><creatorcontrib>Kothary, Nishita, MD</creatorcontrib><creatorcontrib>Sze, Daniel Y., MD, PhD</creatorcontrib><creatorcontrib>Hofmann, Lawrence V., MD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chan, Keith T., MD</au><au>Tye, Grace A., MD</au><au>Popat, Rita A., PhD</au><au>Kuo, William T., MD</au><au>Unver, Kamil, MBiomedE</au><au>Kothary, Nishita, MD</au><au>Sze, Daniel Y., MD, PhD</au><au>Hofmann, Lawrence V., MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Common iliac vein stenosis: a risk factor for oral contraceptive-induced deep vein thrombosis</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>2011-12-01</date><risdate>2011</risdate><volume>205</volume><issue>6</issue><spage>537.e1</spage><epage>537.e6</epage><pages>537.e1-537.e6</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><coden>AJOGAH</coden><abstract>Objective The objective of the study was to determine whether women with significant left common iliac vein stenosis who also use combined oral contraceptives (COCs) have a combined likelihood of deep vein thrombosis (DVT) greater than each independent risk. Study Design This was a case-control study comparing 35 women with DVT against 35 age-matched controls. Common iliac vein diameters were measured from computed tomography and magnetic resonance imaging. Logistic regression modeling was used with adjustment for risk factors. Results DVT was associated with COC use ( P = .022) and with increasing degrees of common iliac vein stenosis ( P = .004). Compared with women without venous stenosis or COC use, the odds of DVT in women with a 70% venous stenosis who also use COCs was associated with a 17-fold increase ( P = .01). Conclusion Venous stenosis and COC use are independent risk factors for DVT. Women concurrently exposed to both have a multiplicative effect resulting in an increased risk of DVT. We recommend further studies to investigate this effect and its potential clinical implications.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>21893308</pmid><doi>10.1016/j.ajog.2011.06.100</doi><tpages>3</tpages></addata></record> |
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| subjects | Adolescent Adult Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Case-Control Studies Constriction, Pathologic - chemically induced Constriction, Pathologic - epidemiology Constriction, Pathologic - pathology Contraceptives, Oral - adverse effects deep vein thrombosis Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Female Gynecology. Andrology. Obstetrics Humans iliac vein Iliac Vein - pathology Logistic Models Magnetic Resonance Imaging Medical sciences Middle Aged Multivariate Analysis Obstetrics and Gynecology oral contraceptive Retrospective Studies Risk Factors Tomography, X-Ray Computed venous stenosis Venous Thrombosis - chemically induced Venous Thrombosis - epidemiology Venous Thrombosis - pathology Young Adult |
| title | Common iliac vein stenosis: a risk factor for oral contraceptive-induced deep vein thrombosis |
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