TLR-dependent T cell activation in autoimmunity

Key Points Toll-like receptors (TLRs) are members of the pattern recognition receptor (PRR) family. They sense pathogen-derived molecules termed pathogen-associated molecular patterns (PAMPs), as well as endogenous molecules termed damage-associated molecular patterns (DAMPs) that are released from...

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Veröffentlicht in:	Nature reviews. Immunology 2011-12, Vol.11 (12), p.807-822
1. Verfasser:	Mills, Kingston H. G.
Format:	Artikel
Sprache:	eng
Schlagworte:	38 631/250/249/1313 631/250/262/2106/2108 631/250/516 Adaptor Proteins, Signal Transducing - physiology Animals Antigen receptors, T cell Antigens Autoantigens Autoantigens - immunology Autoimmune diseases Autoimmunity - immunology Biomedical and Life Sciences Biomedicine Care and treatment Cell activation Cell death Cell Death - immunology Cellular signal transduction Cytokines Cytokines - physiology Freund's adjuvant Health aspects Host-Pathogen Interactions - immunology Humans Immune response Immune system Immunological tolerance Immunology Infection Infection - immunology Infections Inflammation Inflammation - etiology Inflammation - immunology Inflammatory diseases Intestines - immunology Intestines - microbiology Kinases Ligands Lymphocyte Activation - immunology Lymphocytes T Mice Microorganisms Molecular Mimicry Mycobacterium tuberculosis Organ Specificity Pathogens Pattern recognition Physiological aspects Receptors review-article Risk factors Self Tolerance - immunology Signal transduction T cells T-Cell Antigen Receptor Specificity T-Lymphocyte Subsets - immunology Th1 Cells - immunology Th17 Cells - immunology Toll-like receptors Toll-Like Receptors - immunology Tuberculosis Tumor necrosis factor-TNF
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