Inhibition of In-Stent Stenosis by Oral Administration of Bindarit in Porcine Coronary Arteries

OBJECTIVE—We have previously demonstrated that bindarit, a selective inhibitor of monocyte chemotactic proteins (MCPs), is effective in reducing neointimal formation in rodent models of vascular injury by reducing smooth muscle cell proliferation and migration and neointimal macrophage content, effe...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2011-11, Vol.31 (11), p.2448-2454
Hauptverfasser:	Ialenti, Armando, Grassia, Gianluca, Gordon, Peter, Maddaluno, Marcella, Di Lauro, Maria Vittoria, Baker, Andrew H, Guglielmotti, Angelo, Colombo, Antonio, Biondi, Giuseppe, Kennedy, Simon, Maffia, Pasquale
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cell Proliferation - drug effects Coronary heart disease Coronary Stenosis - pathology Coronary Stenosis - prevention & control Coronary Vessels - drug effects Coronary Vessels - pathology Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Heart Indazoles - administration & dosage Indazoles - pharmacology Indazoles - therapeutic use Male Medical sciences Models, Animal Monocyte Chemoattractant Proteins - antagonists & inhibitors Monocyte Chemoattractant Proteins - blood Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - pathology Neointima - pathology Neointima - prevention & control Propionates - administration & dosage Propionates - pharmacology Propionates - therapeutic use Stents Swine Treatment Outcome
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