P2X7 receptor differentially modulates astroglial apoptosis and clasmatodendrosis in the rat brain following status epilepticus

Recently, it has been reported that astroglial loss/dysfunction plays a role in epileptogenesis. In addition, astroglial loss is accompanied by up‐regulation of P2X7 receptor expression in microglia. Therefore, we investigated whether P2X7 receptor is involved in astroglial damages induced by status...

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Veröffentlicht in:	Hippocampus 2011-12, Vol.21 (12), p.1318-1333
Hauptverfasser:	Kim, Ji-Eun, Ryu, Hea Jin, Yeo, Seong-Il, Kang, Tae-Cheon
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - analogs & derivatives Adenosine Triphosphate - pharmacology Animals Apoptosis - drug effects Apoptosis - physiology Astrocytes - drug effects Astrocytes - pathology astroglia CA1 Region, Hippocampal - drug effects CA1 Region, Hippocampal - pathology Cell Shape - drug effects clasmatodendrosis Dendrites - drug effects Dendrites - ultrastructure Dentate Gyrus - drug effects Dentate Gyrus - pathology epilepsy Frontal Lobe - drug effects Frontal Lobe - pathology Male microglia Microglia - drug effects Microglia - pathology P2X7 receptor Parietal Lobe - drug effects Parietal Lobe - pathology Pilocarpine - toxicity Purinergic P2X Receptor Agonists - pharmacology Purinergic P2X Receptor Antagonists - pharmacology Rats Rats, Sprague-Dawley Receptors, Purinergic P2X7 - drug effects Receptors, Purinergic P2X7 - physiology Rosaniline Dyes - pharmacology Status Epilepticus - chemically induced Status Epilepticus - pathology Status Epilepticus - physiopathology
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