Immunogenicity of Recombinant Human Interferon Beta Interacting with Particles of Glass, Metal, and Polystyrene

Aggregates play a major role in the immunogenicity of recombinant human interferon beta (rhIFNβ), a protein used to treat multiple sclerosis. A possible cause of aggregation is interaction between therapeutic protein and surfaces encountered during processing, storage, and administration. Moreover,...

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Veröffentlicht in:Journal of pharmaceutical sciences 2012-01, Vol.101 (1), p.187-199
Hauptverfasser: Van Beers, Miranda M.C., Gilli, Francesca, Schellekens, Huub, Randolph, Theodore W., Jiskoot, Wim
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Sprache:eng
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