Role of BMI‐Associated Loci Identified in GWAS Meta‐Analyses in the Context of Common Childhood Obesity in European Americans
Obesity is a serious health concern for children and adolescents, particularly in Western societies, where its incidence is now considered to have reached epidemic proportions. A number of genetic determinants of adult BMI have already been established through genome wide association studies (GWAS),...
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| Veröffentlicht in: | Obesity (Silver Spring, Md.) Md.), 2011-12, Vol.19 (12), p.2436-2439 |
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| creator | Zhao, Jianhua Bradfield, Jonathan P. Zhang, Haitao Sleiman, Patrick M. Kim, Cecilia E. Glessner, Joseph T. Deliard, Sandra Thomas, Kelly A. Frackelton, Edward C. Li, Mingyao Chiavacci, Rosetta M. Berkowitz, Robert I. Hakonarson, Hakon Grant, Struan F.A. |
| description | Obesity is a serious health concern for children and adolescents, particularly in Western societies, where its incidence is now considered to have reached epidemic proportions. A number of genetic determinants of adult BMI have already been established through genome wide association studies (GWAS), most recently from the GIANT meta‐analysis of such datasets combined. In this current study of European Americans, we examined the 32 loci detected in that GIANT study in the context of common childhood obesity within a cohort of 1,097 cases (defined as BMI ≥95th percentile), together with 2,760 lean controls (defined as BMI |
| doi_str_mv | 10.1038/oby.2011.237 |
| format | Article |
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A number of genetic determinants of adult BMI have already been established through genome wide association studies (GWAS), most recently from the GIANT meta‐analysis of such datasets combined. In this current study of European Americans, we examined the 32 loci detected in that GIANT study in the context of common childhood obesity within a cohort of 1,097 cases (defined as BMI ≥95th percentile), together with 2,760 lean controls (defined as BMI <50th percentile), aged between 2 and 18 years old. Nine of these single‐nucleotide polymorphims (SNPs) yielded at least nominal evidence for association with common childhood obesity, namely at the FTO, TMEM18, NRXN3, MC4R, SEC16B, GNPDA2, TNNI3K, QPCTL, and BDNF loci. However, overall 28 of the 32 loci showed directionally consistent effects to that of the adult BMI meta‐analysis. We conclude that among the 32 loci that have been reported to associate with adult BMI in the largest meta‐analysis of BMI to date, at least nine also contribute to the determination of common obesity in childhood in European Americans, as demonstrated by their associations in our pediatric cohort.</description><identifier>ISSN: 1930-7381</identifier><identifier>EISSN: 1930-739X</identifier><identifier>DOI: 10.1038/oby.2011.237</identifier><identifier>PMID: 21779088</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Body Mass Index ; Case-Control Studies ; Child ; Child, Preschool ; Children & youth ; Cohort Studies ; Ethnicity ; European Continental Ancestry Group - genetics ; Female ; Genetic Predisposition to Disease ; Genetics ; Genome-Wide Association Study ; Humans ; Male ; Meta-analysis ; Meta-Analysis as Topic ; Obesity ; Obesity - genetics ; Philadelphia ; Polymorphism, Single Nucleotide</subject><ispartof>Obesity (Silver Spring, Md.), 2011-12, Vol.19 (12), p.2436-2439</ispartof><rights>2011 North American Association for the Study of Obesity (NAASO)</rights><rights>Copyright Nature Publishing Group Dec 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3597-a0f307261f7ccf7ac6df1aef5d09036784b54adcd70742ea6d63492c1f58a6f03</citedby><cites>FETCH-LOGICAL-c3597-a0f307261f7ccf7ac6df1aef5d09036784b54adcd70742ea6d63492c1f58a6f03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1038%2Foby.2011.237$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1038%2Foby.2011.237$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21779088$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhao, Jianhua</creatorcontrib><creatorcontrib>Bradfield, Jonathan P.</creatorcontrib><creatorcontrib>Zhang, Haitao</creatorcontrib><creatorcontrib>Sleiman, Patrick M.</creatorcontrib><creatorcontrib>Kim, Cecilia E.</creatorcontrib><creatorcontrib>Glessner, Joseph T.</creatorcontrib><creatorcontrib>Deliard, Sandra</creatorcontrib><creatorcontrib>Thomas, Kelly A.</creatorcontrib><creatorcontrib>Frackelton, Edward C.</creatorcontrib><creatorcontrib>Li, Mingyao</creatorcontrib><creatorcontrib>Chiavacci, Rosetta M.</creatorcontrib><creatorcontrib>Berkowitz, Robert I.</creatorcontrib><creatorcontrib>Hakonarson, Hakon</creatorcontrib><creatorcontrib>Grant, Struan F.A.</creatorcontrib><title>Role of BMI‐Associated Loci Identified in GWAS Meta‐Analyses in the Context of Common Childhood Obesity in European Americans</title><title>Obesity (Silver Spring, Md.)</title><addtitle>Obesity (Silver Spring)</addtitle><description>Obesity is a serious health concern for children and adolescents, particularly in Western societies, where its incidence is now considered to have reached epidemic proportions. A number of genetic determinants of adult BMI have already been established through genome wide association studies (GWAS), most recently from the GIANT meta‐analysis of such datasets combined. In this current study of European Americans, we examined the 32 loci detected in that GIANT study in the context of common childhood obesity within a cohort of 1,097 cases (defined as BMI ≥95th percentile), together with 2,760 lean controls (defined as BMI <50th percentile), aged between 2 and 18 years old. Nine of these single‐nucleotide polymorphims (SNPs) yielded at least nominal evidence for association with common childhood obesity, namely at the FTO, TMEM18, NRXN3, MC4R, SEC16B, GNPDA2, TNNI3K, QPCTL, and BDNF loci. However, overall 28 of the 32 loci showed directionally consistent effects to that of the adult BMI meta‐analysis. We conclude that among the 32 loci that have been reported to associate with adult BMI in the largest meta‐analysis of BMI to date, at least nine also contribute to the determination of common obesity in childhood in European Americans, as demonstrated by their associations in our pediatric cohort.</description><subject>Adolescent</subject><subject>Body Mass Index</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children & youth</subject><subject>Cohort Studies</subject><subject>Ethnicity</subject><subject>European Continental Ancestry Group - genetics</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetics</subject><subject>Genome-Wide Association Study</subject><subject>Humans</subject><subject>Male</subject><subject>Meta-analysis</subject><subject>Meta-Analysis as Topic</subject><subject>Obesity</subject><subject>Obesity - genetics</subject><subject>Philadelphia</subject><subject>Polymorphism, Single Nucleotide</subject><issn>1930-7381</issn><issn>1930-739X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90c1u1DAUBeAIgWgp7Fgjiw2bznAdJ3a8nEZtGWmqkfgRsLI89rXGVRIPcSLIDt6AZ-RJcJjSBQtWvrY-Hcn3ZNlzCksKrHoddtMyB0qXORMPslMqGSwEk58e3s8VPcmexHgLUHAo6ePsJKdCSKiq0-zH29AgCY5c3Kx_ff-5ijEYrwe0ZJMGsrbYDd75dPcduf64ekducNCz7HQzRYzz-7BHUoduwG_DHFWHtg0dqfe-sfsQLNnuMPphmunl2IcD6o6sWuy90V18mj1yuon47O48yz5cXb6v3yw22-t1vdosDCulWGhwDETOqRPGOKENt45qdKUFCYyLqtiVhbbGChBFjppbzgqZG-rKSnMH7Cx7dcw99OHLiHFQrY8Gm0Z3GMaoJJSSzxtL8uU_8jaMffrvH8QlhYImdH5Epg8x9ujUofet7idFQc3FqFSMmotRqZjEX9xljrsW7T3-20QC9Ai--gan_4ap7cXnHIRgvwFgPJny</recordid><startdate>201112</startdate><enddate>201112</enddate><creator>Zhao, Jianhua</creator><creator>Bradfield, Jonathan P.</creator><creator>Zhang, Haitao</creator><creator>Sleiman, Patrick M.</creator><creator>Kim, Cecilia E.</creator><creator>Glessner, Joseph T.</creator><creator>Deliard, Sandra</creator><creator>Thomas, Kelly A.</creator><creator>Frackelton, Edward C.</creator><creator>Li, Mingyao</creator><creator>Chiavacci, Rosetta M.</creator><creator>Berkowitz, Robert I.</creator><creator>Hakonarson, Hakon</creator><creator>Grant, Struan F.A.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201112</creationdate><title>Role of BMI‐Associated Loci Identified in GWAS Meta‐Analyses in the Context of Common Childhood Obesity in European Americans</title><author>Zhao, Jianhua ; Bradfield, Jonathan P. ; Zhang, Haitao ; Sleiman, Patrick M. ; Kim, Cecilia E. ; Glessner, Joseph T. ; Deliard, Sandra ; Thomas, Kelly A. ; Frackelton, Edward C. ; Li, Mingyao ; Chiavacci, Rosetta M. ; Berkowitz, Robert I. ; Hakonarson, Hakon ; Grant, Struan F.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3597-a0f307261f7ccf7ac6df1aef5d09036784b54adcd70742ea6d63492c1f58a6f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Body Mass Index</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children & youth</topic><topic>Cohort Studies</topic><topic>Ethnicity</topic><topic>European Continental Ancestry Group - genetics</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Genetics</topic><topic>Genome-Wide Association Study</topic><topic>Humans</topic><topic>Male</topic><topic>Meta-analysis</topic><topic>Meta-Analysis as Topic</topic><topic>Obesity</topic><topic>Obesity - genetics</topic><topic>Philadelphia</topic><topic>Polymorphism, Single Nucleotide</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Jianhua</creatorcontrib><creatorcontrib>Bradfield, Jonathan P.</creatorcontrib><creatorcontrib>Zhang, Haitao</creatorcontrib><creatorcontrib>Sleiman, Patrick M.</creatorcontrib><creatorcontrib>Kim, Cecilia E.</creatorcontrib><creatorcontrib>Glessner, Joseph T.</creatorcontrib><creatorcontrib>Deliard, Sandra</creatorcontrib><creatorcontrib>Thomas, Kelly A.</creatorcontrib><creatorcontrib>Frackelton, Edward C.</creatorcontrib><creatorcontrib>Li, Mingyao</creatorcontrib><creatorcontrib>Chiavacci, Rosetta M.</creatorcontrib><creatorcontrib>Berkowitz, Robert I.</creatorcontrib><creatorcontrib>Hakonarson, Hakon</creatorcontrib><creatorcontrib>Grant, Struan F.A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Obesity (Silver Spring, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Jianhua</au><au>Bradfield, Jonathan P.</au><au>Zhang, Haitao</au><au>Sleiman, Patrick M.</au><au>Kim, Cecilia E.</au><au>Glessner, Joseph T.</au><au>Deliard, Sandra</au><au>Thomas, Kelly A.</au><au>Frackelton, Edward C.</au><au>Li, Mingyao</au><au>Chiavacci, Rosetta M.</au><au>Berkowitz, Robert I.</au><au>Hakonarson, Hakon</au><au>Grant, Struan F.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of BMI‐Associated Loci Identified in GWAS Meta‐Analyses in the Context of Common Childhood Obesity in European Americans</atitle><jtitle>Obesity (Silver Spring, Md.)</jtitle><addtitle>Obesity (Silver Spring)</addtitle><date>2011-12</date><risdate>2011</risdate><volume>19</volume><issue>12</issue><spage>2436</spage><epage>2439</epage><pages>2436-2439</pages><issn>1930-7381</issn><eissn>1930-739X</eissn><abstract>Obesity is a serious health concern for children and adolescents, particularly in Western societies, where its incidence is now considered to have reached epidemic proportions. A number of genetic determinants of adult BMI have already been established through genome wide association studies (GWAS), most recently from the GIANT meta‐analysis of such datasets combined. In this current study of European Americans, we examined the 32 loci detected in that GIANT study in the context of common childhood obesity within a cohort of 1,097 cases (defined as BMI ≥95th percentile), together with 2,760 lean controls (defined as BMI <50th percentile), aged between 2 and 18 years old. Nine of these single‐nucleotide polymorphims (SNPs) yielded at least nominal evidence for association with common childhood obesity, namely at the FTO, TMEM18, NRXN3, MC4R, SEC16B, GNPDA2, TNNI3K, QPCTL, and BDNF loci. However, overall 28 of the 32 loci showed directionally consistent effects to that of the adult BMI meta‐analysis. We conclude that among the 32 loci that have been reported to associate with adult BMI in the largest meta‐analysis of BMI to date, at least nine also contribute to the determination of common obesity in childhood in European Americans, as demonstrated by their associations in our pediatric cohort.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21779088</pmid><doi>10.1038/oby.2011.237</doi><tpages>4</tpages></addata></record> |
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| ispartof | Obesity (Silver Spring, Md.), 2011-12, Vol.19 (12), p.2436-2439 |
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| subjects | Adolescent Body Mass Index Case-Control Studies Child Child, Preschool Children & youth Cohort Studies Ethnicity European Continental Ancestry Group - genetics Female Genetic Predisposition to Disease Genetics Genome-Wide Association Study Humans Male Meta-analysis Meta-Analysis as Topic Obesity Obesity - genetics Philadelphia Polymorphism, Single Nucleotide |
| title | Role of BMI‐Associated Loci Identified in GWAS Meta‐Analyses in the Context of Common Childhood Obesity in European Americans |
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