A meta-analysis of HLA-DR polymorphism and genetic susceptibility to idiopathic dilated cardiomyopathy
Idiopathic dilated cardiomyopathy (IDC) has been hypothesized as a multifactorial disorder initiated by an environment trigger in individuals with predisposing human leukocyte antigen (HLA) alleles. Published data on the association between HLA-DR polymorphism and IDC risk are inconclusive. To deriv...
Gespeichert in:
| Veröffentlicht in: | Molecular biology reports 2012, Vol.39 (1), p.221-226 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 226 |
|---|---|
| container_issue | 1 |
| container_start_page | 221 |
| container_title | Molecular biology reports |
| container_volume | 39 |
| creator | Jin, Bo Luo, Xin-Ping Ni, Huan-Chun Shen, Wei Shi, Hai-Ming Li, Yong |
| description | Idiopathic dilated cardiomyopathy (IDC) has been hypothesized as a multifactorial disorder initiated by an environment trigger in individuals with predisposing human leukocyte antigen (HLA) alleles. Published data on the association between HLA-DR polymorphism and IDC risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. A total of 19 case–control studies including 1,378 cases and 10,383 controls provided data on the association between HLA-DR polymorphism and genetic susceptibility to IDC. Overall, statistically elevated frequencies of HLA-DR4 (OR 1.58; 95% CI 1.21–2.07;
P
= 0.0009) and HLA-DR5 (OR 1.35; 95% CI 1.05–1.73;
P
= 0.02) alleles were found in patients with IDC compared with controls. Individuals with HLA-DR3 antigen have a protective effect against IDC (OR 0.72; 95% CI 0.58–0.90;
P
= 0.004). In summary, this meta-analysis indicated that certain HLA-DR alleles may be genetic markers for susceptibility and resistance to IDC. |
| doi_str_mv | 10.1007/s11033-011-0729-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_905872203</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1008827786</sourcerecordid><originalsourceid>FETCH-LOGICAL-c403t-3a6f7c3c81ccd604991ebbec630f11b79f6d026bb1eb6ad02739b11a66a34fa13</originalsourceid><addsrcrecordid>eNp9kUFP3DAUhK0K1F22_QFckMWFXgx-dmInxxVQQFoJCbXnyHGcXa-SONjOIf--hqWthAQnW_O-N7ZmEDoFegmUyqsAQDknFIBQyUoyf0FLyCUnWSmLI7SknALJihwW6CSEPaU0A5l_RQsGeS6k5EvUrnFvoiJqUN0cbMCuxfebNbl5wqPr5t75cWdDj9XQ4K0ZTLQahyloM0Zb287GGUeHbWPdqOIuDRvbqWgarJVPYj-_6vM3dNyqLpjvb-cK_f55--v6nmwe7x6u1xuiM8oj4Uq0UnNdgNaNoFlZgqlrowWnLUAty1Y0lIm6TrJQ6Sp5WQMoIRTPWgV8hS4OvqN3z5MJsept-mzXqcG4KVQlzQvJWEpthX58SqaAi4JJWYiEnr9D927yKbBXP8ZyJliC4ABp70Lwpq1Gb3vl5-T0YiarQ1tVaqt6aaua087Zm_FU96b5t_G3ngSwAxDSaNga___lj13_AG67oGs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>905225262</pqid></control><display><type>article</type><title>A meta-analysis of HLA-DR polymorphism and genetic susceptibility to idiopathic dilated cardiomyopathy</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Jin, Bo ; Luo, Xin-Ping ; Ni, Huan-Chun ; Shen, Wei ; Shi, Hai-Ming ; Li, Yong</creator><creatorcontrib>Jin, Bo ; Luo, Xin-Ping ; Ni, Huan-Chun ; Shen, Wei ; Shi, Hai-Ming ; Li, Yong</creatorcontrib><description>Idiopathic dilated cardiomyopathy (IDC) has been hypothesized as a multifactorial disorder initiated by an environment trigger in individuals with predisposing human leukocyte antigen (HLA) alleles. Published data on the association between HLA-DR polymorphism and IDC risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. A total of 19 case–control studies including 1,378 cases and 10,383 controls provided data on the association between HLA-DR polymorphism and genetic susceptibility to IDC. Overall, statistically elevated frequencies of HLA-DR4 (OR 1.58; 95% CI 1.21–2.07;
P
= 0.0009) and HLA-DR5 (OR 1.35; 95% CI 1.05–1.73;
P
= 0.02) alleles were found in patients with IDC compared with controls. Individuals with HLA-DR3 antigen have a protective effect against IDC (OR 0.72; 95% CI 0.58–0.90;
P
= 0.004). In summary, this meta-analysis indicated that certain HLA-DR alleles may be genetic markers for susceptibility and resistance to IDC.</description><identifier>ISSN: 0301-4851</identifier><identifier>EISSN: 1573-4978</identifier><identifier>DOI: 10.1007/s11033-011-0729-y</identifier><identifier>PMID: 21556773</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Animal Anatomy ; Animal Biochemistry ; Biomedical and Life Sciences ; Cardiomyopathy, Dilated - genetics ; Cardiovascular disease ; Case-Control Studies ; Data processing ; Dilated cardiomyopathy ; Gene polymorphism ; Genetic Association Studies ; Genetic markers ; Genetic Predisposition to Disease - genetics ; Genetics ; Histocompatibility antigen HLA ; Histology ; HLA-DR Antigens - genetics ; Humans ; Leukocytes ; Life Sciences ; Meta-analysis ; Molecular biology ; Morphology ; Polymorphism ; Polymorphism, Genetic - genetics ; Reviews ; Sensitivity and Specificity</subject><ispartof>Molecular biology reports, 2012, Vol.39 (1), p.221-226</ispartof><rights>Springer Science+Business Media B.V. 2011</rights><rights>Springer Science+Business Media B.V. 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-3a6f7c3c81ccd604991ebbec630f11b79f6d026bb1eb6ad02739b11a66a34fa13</citedby><cites>FETCH-LOGICAL-c403t-3a6f7c3c81ccd604991ebbec630f11b79f6d026bb1eb6ad02739b11a66a34fa13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11033-011-0729-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11033-011-0729-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21556773$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jin, Bo</creatorcontrib><creatorcontrib>Luo, Xin-Ping</creatorcontrib><creatorcontrib>Ni, Huan-Chun</creatorcontrib><creatorcontrib>Shen, Wei</creatorcontrib><creatorcontrib>Shi, Hai-Ming</creatorcontrib><creatorcontrib>Li, Yong</creatorcontrib><title>A meta-analysis of HLA-DR polymorphism and genetic susceptibility to idiopathic dilated cardiomyopathy</title><title>Molecular biology reports</title><addtitle>Mol Biol Rep</addtitle><addtitle>Mol Biol Rep</addtitle><description>Idiopathic dilated cardiomyopathy (IDC) has been hypothesized as a multifactorial disorder initiated by an environment trigger in individuals with predisposing human leukocyte antigen (HLA) alleles. Published data on the association between HLA-DR polymorphism and IDC risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. A total of 19 case–control studies including 1,378 cases and 10,383 controls provided data on the association between HLA-DR polymorphism and genetic susceptibility to IDC. Overall, statistically elevated frequencies of HLA-DR4 (OR 1.58; 95% CI 1.21–2.07;
P
= 0.0009) and HLA-DR5 (OR 1.35; 95% CI 1.05–1.73;
P
= 0.02) alleles were found in patients with IDC compared with controls. Individuals with HLA-DR3 antigen have a protective effect against IDC (OR 0.72; 95% CI 0.58–0.90;
P
= 0.004). In summary, this meta-analysis indicated that certain HLA-DR alleles may be genetic markers for susceptibility and resistance to IDC.</description><subject>Animal Anatomy</subject><subject>Animal Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Cardiomyopathy, Dilated - genetics</subject><subject>Cardiovascular disease</subject><subject>Case-Control Studies</subject><subject>Data processing</subject><subject>Dilated cardiomyopathy</subject><subject>Gene polymorphism</subject><subject>Genetic Association Studies</subject><subject>Genetic markers</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genetics</subject><subject>Histocompatibility antigen HLA</subject><subject>Histology</subject><subject>HLA-DR Antigens - genetics</subject><subject>Humans</subject><subject>Leukocytes</subject><subject>Life Sciences</subject><subject>Meta-analysis</subject><subject>Molecular biology</subject><subject>Morphology</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Reviews</subject><subject>Sensitivity and Specificity</subject><issn>0301-4851</issn><issn>1573-4978</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kUFP3DAUhK0K1F22_QFckMWFXgx-dmInxxVQQFoJCbXnyHGcXa-SONjOIf--hqWthAQnW_O-N7ZmEDoFegmUyqsAQDknFIBQyUoyf0FLyCUnWSmLI7SknALJihwW6CSEPaU0A5l_RQsGeS6k5EvUrnFvoiJqUN0cbMCuxfebNbl5wqPr5t75cWdDj9XQ4K0ZTLQahyloM0Zb287GGUeHbWPdqOIuDRvbqWgarJVPYj-_6vM3dNyqLpjvb-cK_f55--v6nmwe7x6u1xuiM8oj4Uq0UnNdgNaNoFlZgqlrowWnLUAty1Y0lIm6TrJQ6Sp5WQMoIRTPWgV8hS4OvqN3z5MJsept-mzXqcG4KVQlzQvJWEpthX58SqaAi4JJWYiEnr9D927yKbBXP8ZyJliC4ABp70Lwpq1Gb3vl5-T0YiarQ1tVaqt6aaua087Zm_FU96b5t_G3ngSwAxDSaNga___lj13_AG67oGs</recordid><startdate>2012</startdate><enddate>2012</enddate><creator>Jin, Bo</creator><creator>Luo, Xin-Ping</creator><creator>Ni, Huan-Chun</creator><creator>Shen, Wei</creator><creator>Shi, Hai-Ming</creator><creator>Li, Yong</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>2012</creationdate><title>A meta-analysis of HLA-DR polymorphism and genetic susceptibility to idiopathic dilated cardiomyopathy</title><author>Jin, Bo ; Luo, Xin-Ping ; Ni, Huan-Chun ; Shen, Wei ; Shi, Hai-Ming ; Li, Yong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-3a6f7c3c81ccd604991ebbec630f11b79f6d026bb1eb6ad02739b11a66a34fa13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animal Anatomy</topic><topic>Animal Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Cardiomyopathy, Dilated - genetics</topic><topic>Cardiovascular disease</topic><topic>Case-Control Studies</topic><topic>Data processing</topic><topic>Dilated cardiomyopathy</topic><topic>Gene polymorphism</topic><topic>Genetic Association Studies</topic><topic>Genetic markers</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Genetics</topic><topic>Histocompatibility antigen HLA</topic><topic>Histology</topic><topic>HLA-DR Antigens - genetics</topic><topic>Humans</topic><topic>Leukocytes</topic><topic>Life Sciences</topic><topic>Meta-analysis</topic><topic>Molecular biology</topic><topic>Morphology</topic><topic>Polymorphism</topic><topic>Polymorphism, Genetic - genetics</topic><topic>Reviews</topic><topic>Sensitivity and Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jin, Bo</creatorcontrib><creatorcontrib>Luo, Xin-Ping</creatorcontrib><creatorcontrib>Ni, Huan-Chun</creatorcontrib><creatorcontrib>Shen, Wei</creatorcontrib><creatorcontrib>Shi, Hai-Ming</creatorcontrib><creatorcontrib>Li, Yong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular biology reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jin, Bo</au><au>Luo, Xin-Ping</au><au>Ni, Huan-Chun</au><au>Shen, Wei</au><au>Shi, Hai-Ming</au><au>Li, Yong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A meta-analysis of HLA-DR polymorphism and genetic susceptibility to idiopathic dilated cardiomyopathy</atitle><jtitle>Molecular biology reports</jtitle><stitle>Mol Biol Rep</stitle><addtitle>Mol Biol Rep</addtitle><date>2012</date><risdate>2012</risdate><volume>39</volume><issue>1</issue><spage>221</spage><epage>226</epage><pages>221-226</pages><issn>0301-4851</issn><eissn>1573-4978</eissn><abstract>Idiopathic dilated cardiomyopathy (IDC) has been hypothesized as a multifactorial disorder initiated by an environment trigger in individuals with predisposing human leukocyte antigen (HLA) alleles. Published data on the association between HLA-DR polymorphism and IDC risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. A total of 19 case–control studies including 1,378 cases and 10,383 controls provided data on the association between HLA-DR polymorphism and genetic susceptibility to IDC. Overall, statistically elevated frequencies of HLA-DR4 (OR 1.58; 95% CI 1.21–2.07;
P
= 0.0009) and HLA-DR5 (OR 1.35; 95% CI 1.05–1.73;
P
= 0.02) alleles were found in patients with IDC compared with controls. Individuals with HLA-DR3 antigen have a protective effect against IDC (OR 0.72; 95% CI 0.58–0.90;
P
= 0.004). In summary, this meta-analysis indicated that certain HLA-DR alleles may be genetic markers for susceptibility and resistance to IDC.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>21556773</pmid><doi>10.1007/s11033-011-0729-y</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0301-4851 |
| ispartof | Molecular biology reports, 2012, Vol.39 (1), p.221-226 |
| issn | 0301-4851 1573-4978 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_905872203 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animal Anatomy Animal Biochemistry Biomedical and Life Sciences Cardiomyopathy, Dilated - genetics Cardiovascular disease Case-Control Studies Data processing Dilated cardiomyopathy Gene polymorphism Genetic Association Studies Genetic markers Genetic Predisposition to Disease - genetics Genetics Histocompatibility antigen HLA Histology HLA-DR Antigens - genetics Humans Leukocytes Life Sciences Meta-analysis Molecular biology Morphology Polymorphism Polymorphism, Genetic - genetics Reviews Sensitivity and Specificity |
| title | A meta-analysis of HLA-DR polymorphism and genetic susceptibility to idiopathic dilated cardiomyopathy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T15%3A56%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20meta-analysis%20of%20HLA-DR%20polymorphism%20and%20genetic%20susceptibility%20to%20idiopathic%20dilated%20cardiomyopathy&rft.jtitle=Molecular%20biology%20reports&rft.au=Jin,%20Bo&rft.date=2012&rft.volume=39&rft.issue=1&rft.spage=221&rft.epage=226&rft.pages=221-226&rft.issn=0301-4851&rft.eissn=1573-4978&rft_id=info:doi/10.1007/s11033-011-0729-y&rft_dat=%3Cproquest_cross%3E1008827786%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=905225262&rft_id=info:pmid/21556773&rfr_iscdi=true |