Direct, Noncatalytic Mechanism of IKK Inhibition by A20

A20 is a potent anti-inflammatory protein that inhibits NF-κB, and A20 dysfunction is associated with autoimmunity and B cell lymphoma. A20 harbors a deubiquitination enzyme domain and can employ multiple mechanisms to antagonize ubiquitination upstream of NEMO, a regulatory subunit of the IκB kinas...

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Veröffentlicht in:	Molecular cell 2011-11, Vol.44 (4), p.559-571
Hauptverfasser:	Skaug, Brian, Chen, Jueqi, Du, Fenghe, He, Jin, Ma, Averil, Chen, Zhijian J.
Format:	Artikel
Sprache:	eng
Schlagworte:	autoimmunity Autoimmunity - genetics DNA-Binding Proteins Enzyme Activation - genetics enzymes Gene Expression HEK293 Cells HeLa Cells Humans I-kappa B Kinase - antagonists & inhibitors I-kappa B Kinase - genetics I-kappa B Kinase - metabolism Immunoprecipitation Inflammation - genetics Inflammation - metabolism inhibition Interleukin-1beta - pharmacology Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Lymphoma, B-Cell - genetics Lymphoma, B-Cell - metabolism MAP Kinase Kinase Kinases - genetics MAP Kinase Kinase Kinases - metabolism neoplasm cells NF-kappa B - antagonists & inhibitors NF-kappa B - genetics NF-kappa B - metabolism Nuclear Proteins - genetics Nuclear Proteins - metabolism Phosphorylation Polyubiquitin Protein Binding Protein Structure, Tertiary Signal Transduction - drug effects Signal Transduction - genetics transcription factor NF-kappa B Tumor Necrosis Factor alpha-Induced Protein 3 Ubiquitination Zinc Fingers - genetics
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