Characterization of testicular expression of P450 17α-hydroxylase, 17,20-lyase in zebrafish and its perturbation by the pharmaceutical fungicide clotrimazole

Highlights ► Cyp17-I enzyme was immunolocalized within the gonadal tissue in zebrafish. ► In vivo , clotrimazole increased cyp17a1 gene and protein expressions in testis. ► In testis explants, clotrimazole inhibited 11-ketotestosterone release. ► Clotrimazole affects differently testicular steroidog...

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Veröffentlicht in:	General and comparative endocrinology 2011-12, Vol.174 (3), p.309-317
Hauptverfasser:	Hinfray, Nathalie, Baudiffier, Damien, Leal, Marcelo C, Porcher, Jean-Marc, Aït-Aïssa, Sélim, Le Gac, Florence, Schulz, Rüdiger W, Brion, François
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antifungal Agents - pharmacology Brain - drug effects Brain - enzymology Brain - metabolism Cells, Cultured Clotrimazole Clotrimazole - pharmacology cyp17a1 cytochrome P-450 Danio rerio endocrinology Endocrinology & Metabolism enzyme activity explants Female fish Freshwater fungicides gene expression Gene Expression Regulation, Enzymologic - drug effects genes Gonads - drug effects Gonads - enzymology Gonads - metabolism Male Pharmaceutical Primary Cell Culture protein synthesis Steroid 17-alpha-Hydroxylase - genetics Steroid 17-alpha-Hydroxylase - metabolism Steroidogenesis testes Testis - chemistry Testis - drug effects Testis - enzymology Testis - metabolism Testis culture Testosterone - analogs & derivatives Testosterone - metabolism Zebrafish Zebrafish - genetics Zebrafish - metabolism Zebrafish Proteins - genetics Zebrafish Proteins - metabolism
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