Pharmacokinetic and Pharmacodynamic Properties of the Glucokinase Activator MK-0941 in Rodent Models of Type 2 Diabetes and Healthy Dogs

Glucokinase activators (GKAs) are small-molecule agents that enhance glucose sensing by pancreatic β cells and glucose metabolism by hepatocytes. There is strong interest in these agents as potential therapies for type 2 diabetes. Here, we report key pharmacokinetic and pharmacodynamic findings from...

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Veröffentlicht in:	Molecular pharmacology 2011-12, Vol.80 (6), p.1156-1165
Hauptverfasser:	Eiki, Jun-ichi, Nagata, Yasufumi, Futamura, Mayumi, Sasaki-Yamamoto, Kaori, Iino, Tomoharu, Nishimura, Teruyuki, Chiba, Masato, Ohyama, Sumika, Yoshida-Yoshimioto, Riki, Fujii, Kenji, Hosaka, Hideka, Goto-Shimazaki, Hiroko, Kadotani, Akito, Ohe, Tomoyuki, Lin, Songnian, Langdon, Ronald B., Berger, Joel P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzamides - pharmacokinetics Benzamides - pharmacology Blood Glucose - drug effects Blood Glucose - metabolism Cells, Cultured Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - enzymology Disease Models, Animal Dogs Enzyme Activation - drug effects Enzyme Activation - physiology Glucokinase - metabolism Humans Hypoglycemic Agents - pharmacokinetics Hypoglycemic Agents - pharmacology Hypoglycemic Agents - therapeutic use Male Mice Mice, Inbred C57BL Mice, Inbred ICR Rats Rats, Sprague-Dawley Rats, Wistar Sulfones - pharmacokinetics Sulfones - pharmacology
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