Effect of apolipoprotein E and butyrylcholinesterase genotypes on cognitive response to cholinesterase inhibitor treatment at different stages of Alzheimer's disease

Effect of apolipoprotein E and butyrylcholinesterase genotypes on cognitive response to cholinesterase inhibitor treatment at different stages of Alzheimer's disease

Factors that influence response to drug treatment are of increasing importance. We report an analysis of genetic factors affecting response to cholinesterase inhibitor therapy in 165 subjects with Alzheimer's disease (AD). The presence of apolipoprotein E ɛ4 ( APOE ɛ4 ) allele was associated wi...

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Veröffentlicht in:The pharmacogenomics journal 2011-12, Vol.11 (6), p.444-450
Hauptverfasser: Patterson, C E, Todd, S A, Passmore, A P
Format: Artikel
Sprache:eng
Schlagworte:
631/208/727
631/378/2649
692/699/375/365/1283
692/700/565/1436
Aged
Aged, 80 and over
Alzheimer Disease - drug therapy
Alzheimer Disease - genetics
Alzheimer Disease - psychology
Alzheimer's disease
Apolipoprotein E
Apolipoprotein E4 - genetics
Apolipoproteins
Biomedical and Life Sciences
Biomedicine
Butyrylcholinesterase - genetics
Cholinesterase inhibitors
Cholinesterase Inhibitors - therapeutic use
Cognition
Cognitive ability
Decision making
Diagnosis
Dosage and administration
Drug therapy
Enzyme inhibitors
Female
Gene Expression
Genetic analysis
Genetic factors
Genotype
Genotypes
Human Genetics
Humans
Identification and classification
Male
Middle Aged
Neurodegenerative diseases
Oncology
original-article
Pharmacotherapy
Properties
Psychological Tests
Psychopharmacology
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Beschreibung
Zusammenfassung:Factors that influence response to drug treatment are of increasing importance. We report an analysis of genetic factors affecting response to cholinesterase inhibitor therapy in 165 subjects with Alzheimer's disease (AD). The presence of apolipoprotein E ɛ4 ( APOE ɛ4 ) allele was associated with early and late cognitive response to cholinesterase inhibitor treatment in mild AD (Mini-Mental State Examination (MMSE) ⩾21) ( P
ISSN:1470-269X
1473-1150
DOI:10.1038/tpj.2010.61