Aluminum toxicity and astrocyte dysfunction: A metabolic link to neurological disorders
Aluminum (Al) has been implicated in a variety of neurological diseases. However, the molecular mechanisms that enable Al to be involved in these disorders have yet to be fully delineated. Using astrocytes as a model of the cerebral cellular system, we have uncovered the biochemical networks that ar...
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| Veröffentlicht in: | Journal of inorganic biochemistry 2011-11, Vol.105 (11), p.1513-1517 |
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| container_title | Journal of inorganic biochemistry |
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| creator | Lemire, Joseph Appanna, Vasu D. |
| description | Aluminum (Al) has been implicated in a variety of neurological diseases. However, the molecular mechanisms that enable Al to be involved in these disorders have yet to be fully delineated. Using astrocytes as a model of the cerebral cellular system, we have uncovered the biochemical networks that are affected by Al toxicity. In this review, we reveal how the inhibitory influence of Al on ATP production and on mitochondrial functions help generate globular astrocytes that are fat producing machines. These biological events may be the contributing factors to Al-triggered brain disorders.
A definitive link between aluminum and neurological disorders remains elusive. Here we describe a metabolic link where by aluminum-stressed astrocytes experience mitochondrial dysfunction and lack of oxidative energy production. This results in a loss of cellular morphology and an accumulation of lipids. Both factors which could contribute to Al-induced neurological disorders.
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| doi_str_mv | 10.1016/j.jinorgbio.2011.07.001 |
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A definitive link between aluminum and neurological disorders remains elusive. Here we describe a metabolic link where by aluminum-stressed astrocytes experience mitochondrial dysfunction and lack of oxidative energy production. This results in a loss of cellular morphology and an accumulation of lipids. Both factors which could contribute to Al-induced neurological disorders.
[Display omitted]</description><identifier>ISSN: 0162-0134</identifier><identifier>EISSN: 1873-3344</identifier><identifier>DOI: 10.1016/j.jinorgbio.2011.07.001</identifier><identifier>PMID: 22099161</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Al toxicity ; Aluminum - toxicity ; Astrocytes ; Astrocytes - metabolism ; Astrocytes - pathology ; ATP ; Cell Shape - drug effects ; Energy Metabolism ; Fat factories ; Globular ; Humans ; l-carnitine ; Lipid Metabolism ; Nervous System Diseases - chemically induced ; Nervous System Diseases - metabolism ; Nervous System Diseases - pathology ; Oxidative Stress</subject><ispartof>Journal of inorganic biochemistry, 2011-11, Vol.105 (11), p.1513-1517</ispartof><rights>2011 Elsevier Inc.</rights><rights>Copyright © 2011 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-f600f071ffc888a778b4dc0527dac2f5948cf86b2e3d20eddba494d58156a7b83</citedby><cites>FETCH-LOGICAL-c436t-f600f071ffc888a778b4dc0527dac2f5948cf86b2e3d20eddba494d58156a7b83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0162013411001814$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22099161$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lemire, Joseph</creatorcontrib><creatorcontrib>Appanna, Vasu D.</creatorcontrib><title>Aluminum toxicity and astrocyte dysfunction: A metabolic link to neurological disorders</title><title>Journal of inorganic biochemistry</title><addtitle>J Inorg Biochem</addtitle><description>Aluminum (Al) has been implicated in a variety of neurological diseases. However, the molecular mechanisms that enable Al to be involved in these disorders have yet to be fully delineated. Using astrocytes as a model of the cerebral cellular system, we have uncovered the biochemical networks that are affected by Al toxicity. In this review, we reveal how the inhibitory influence of Al on ATP production and on mitochondrial functions help generate globular astrocytes that are fat producing machines. These biological events may be the contributing factors to Al-triggered brain disorders.
A definitive link between aluminum and neurological disorders remains elusive. Here we describe a metabolic link where by aluminum-stressed astrocytes experience mitochondrial dysfunction and lack of oxidative energy production. This results in a loss of cellular morphology and an accumulation of lipids. Both factors which could contribute to Al-induced neurological disorders.
[Display omitted]</description><subject>Al toxicity</subject><subject>Aluminum - toxicity</subject><subject>Astrocytes</subject><subject>Astrocytes - metabolism</subject><subject>Astrocytes - pathology</subject><subject>ATP</subject><subject>Cell Shape - drug effects</subject><subject>Energy Metabolism</subject><subject>Fat factories</subject><subject>Globular</subject><subject>Humans</subject><subject>l-carnitine</subject><subject>Lipid Metabolism</subject><subject>Nervous System Diseases - chemically induced</subject><subject>Nervous System Diseases - metabolism</subject><subject>Nervous System Diseases - pathology</subject><subject>Oxidative Stress</subject><issn>0162-0134</issn><issn>1873-3344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFu1DAURS0EotOWXwDvWCU8O07ssBtVtFSqxAbUpeXYz5WHxC62g5i_J9WUblm9zbn36h1CPjBoGbDh06E9hJjywxRSy4GxFmQLwF6RHVOya7pOiNdkt5G8AdaJM3JeygEA-l7It-SMcxhHNrAdud_P6xLiutCa_gQb6pGa6KgpNSd7rEjdsfg12hpS_Ez3dMFqpjQHS-cQf24hGnHNaU4PwZqZulBSdpjLJXnjzVzw3fO9ID-uv3y_-trcfbu5vdrfNVZ0Q238AOBBMu-tUspIqSbhLPRcOmO570ehrFfDxLFzHNC5yYhRuF6xfjByUt0F-Xjqfczp14ql6iUUi_NsIqa16BH6QY5S8o2UJ9LmVEpGrx9zWEw-agb6Sao-6Bep-kmqBqk3qVvy_fPGOi3oXnL_LG7A_gTg9unvgFkXGzBadCGjrdql8N-Rvz_YjpE</recordid><startdate>20111101</startdate><enddate>20111101</enddate><creator>Lemire, Joseph</creator><creator>Appanna, Vasu D.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20111101</creationdate><title>Aluminum toxicity and astrocyte dysfunction: A metabolic link to neurological disorders</title><author>Lemire, Joseph ; Appanna, Vasu D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-f600f071ffc888a778b4dc0527dac2f5948cf86b2e3d20eddba494d58156a7b83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Al toxicity</topic><topic>Aluminum - toxicity</topic><topic>Astrocytes</topic><topic>Astrocytes - metabolism</topic><topic>Astrocytes - pathology</topic><topic>ATP</topic><topic>Cell Shape - drug effects</topic><topic>Energy Metabolism</topic><topic>Fat factories</topic><topic>Globular</topic><topic>Humans</topic><topic>l-carnitine</topic><topic>Lipid Metabolism</topic><topic>Nervous System Diseases - chemically induced</topic><topic>Nervous System Diseases - metabolism</topic><topic>Nervous System Diseases - pathology</topic><topic>Oxidative Stress</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lemire, Joseph</creatorcontrib><creatorcontrib>Appanna, Vasu D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of inorganic biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lemire, Joseph</au><au>Appanna, Vasu D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aluminum toxicity and astrocyte dysfunction: A metabolic link to neurological disorders</atitle><jtitle>Journal of inorganic biochemistry</jtitle><addtitle>J Inorg Biochem</addtitle><date>2011-11-01</date><risdate>2011</risdate><volume>105</volume><issue>11</issue><spage>1513</spage><epage>1517</epage><pages>1513-1517</pages><issn>0162-0134</issn><eissn>1873-3344</eissn><abstract>Aluminum (Al) has been implicated in a variety of neurological diseases. However, the molecular mechanisms that enable Al to be involved in these disorders have yet to be fully delineated. Using astrocytes as a model of the cerebral cellular system, we have uncovered the biochemical networks that are affected by Al toxicity. In this review, we reveal how the inhibitory influence of Al on ATP production and on mitochondrial functions help generate globular astrocytes that are fat producing machines. These biological events may be the contributing factors to Al-triggered brain disorders.
A definitive link between aluminum and neurological disorders remains elusive. Here we describe a metabolic link where by aluminum-stressed astrocytes experience mitochondrial dysfunction and lack of oxidative energy production. This results in a loss of cellular morphology and an accumulation of lipids. Both factors which could contribute to Al-induced neurological disorders.
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| subjects | Al toxicity Aluminum - toxicity Astrocytes Astrocytes - metabolism Astrocytes - pathology ATP Cell Shape - drug effects Energy Metabolism Fat factories Globular Humans l-carnitine Lipid Metabolism Nervous System Diseases - chemically induced Nervous System Diseases - metabolism Nervous System Diseases - pathology Oxidative Stress |
| title | Aluminum toxicity and astrocyte dysfunction: A metabolic link to neurological disorders |
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