A prospective and open-label study for the efficacy and safety of telbivudine in pregnancy for the prevention of perinatal transmission of hepatitis B virus infection

Background & Aims In the Asia–Pacific region, perinatal transmission of the hepatitis B virus (HBV) is the primary cause of chronic hepatitis B infection. Despite the use of HBIG and HBV vaccination, HBV perinatal transmission (PT) occurs in 10–30% of infants born to highly viremic mothers. We e...

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Veröffentlicht in:	Journal of hepatology 2011-12, Vol.55 (6), p.1215-1221
Hauptverfasser:	Han, Guo-Rong, Cao, Min-Kai, Zhao, Wei, Jiang, Hong-Xiu, Wang, Cui-Min, Bai, Shu-Fen, Yue, Xin, Wang, Gen-Ju, Tang, Xun, Fang, Zhi-Xun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Antiviral Agents - adverse effects Antiviral Agents - therapeutic use Biological and medical sciences Chronic hepatitis B DNA, Viral - blood Female Gastroenterology and Hepatology Gastroenterology. Liver. Pancreas. Abdomen Hepatitis B Antibodies - administration & dosage Hepatitis B e Antigens - blood Hepatitis B Surface Antigens - blood Hepatitis B Vaccines - administration & dosage Hepatitis B virus Hepatitis B, Chronic - complications Hepatitis B, Chronic - drug therapy Hepatitis B, Chronic - prevention & control Hepatitis B, Chronic - transmission Human viral diseases Humans Infant Infant, Newborn Infectious Disease Transmission, Vertical - prevention & control Infectious diseases Male Medical sciences Nucleosides - adverse effects Nucleosides - therapeutic use Perinatal transmission Pharmacology. Drug treatments Pregnancy Pregnancy Complications, Infectious - drug therapy Pregnancy Complications, Infectious - virology Prospective Studies Pyrimidinones - adverse effects Pyrimidinones - therapeutic use Telbivudine Thymidine - analogs & derivatives Treatment Outcome Viral diseases Viral hepatitis Young Adult
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