Inflammatory diseases of the parathyroid gland
Talat N, Diaz‐Cano S & Schulte K‐M (2011) Histopathology59, 897–908 Inflammatory diseases of the parathyroid gland Aims: Inflammatory disorders of the parathyroid gland are very rare as compared with those of other endocrine organs. The aim of this study was to provide the first systematic revi...
Gespeichert in:
| Veröffentlicht in: | Histopathology 2011-11, Vol.59 (5), p.897-908 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 908 |
|---|---|
| container_issue | 5 |
| container_start_page | 897 |
| container_title | Histopathology |
| container_volume | 59 |
| creator | Talat, Nadia Diaz-Cano, Salvador Schulte, Klaus-Martin |
| description | Talat N, Diaz‐Cano S & Schulte K‐M
(2011) Histopathology59, 897–908
Inflammatory diseases of the parathyroid gland
Aims: Inflammatory disorders of the parathyroid gland are very rare as compared with those of other endocrine organs. The aim of this study was to provide the first systematic review of this condition.
Methods and results: A 42‐year‐old patient underwent surgery for recurrent secondary hyperparathyroidism. Histology showed hyperplastic parathyroiditis defined by a mixed inflammatory infiltrate with active germinal centres. Molecular markers revealed significant upregulation of CD68 in an ischaemic background (hypoxia‐inducible factor 1 upregulation) with mitochondrial reaction (malate dehydrogenase 2 upregulation) and hyperparathyroidism (carbonic anhydrase 4 upregulation). Our case demonstrates true intraparathyroid inflammation with terminal B‐cell differentiation. We searched PubMed, ISI Thompson and Google Scholar up to January 2011, using the terms ‘parathyroiditis’, ‘inflammation of parathyroid gland’, ‘lymphocytic infiltrate’, ‘tuberculosis of the parathyroid’, ‘sarcoidosis’, and ‘graulomatous inflammation’. Three autopsy series, 27 articles and 96 case reports with inflammatory parathyroid disorders were identified. Autopsy series showed lymphocytic infiltrates in up to 16% of all cases. The entire material reported lymphocytic infiltrates (n = 69), parathyroiditis with germinal centres (n = 15), sarcoidosis (n = 6), tuberculosis (n = 4), and other granulomatous diseases (n = 2).
Conclusions: Distinct inflammatory and granulomatous processes in the parathyroid gland are rare. Scanty lymphocytic infiltrates are common, and occur in generalized inflammatory conditions or venous congestion. We note the surprising absence of an association between histological proof of parathyroiditis and hypoparathyroidism. |
| doi_str_mv | 10.1111/j.1365-2559.2011.04001.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_905679141</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>905679141</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4861-d16ce539c6af47df8f66a20d9dadc10af4e3f8caef0dc8928635d2119bc38cc83</originalsourceid><addsrcrecordid>eNqNkMlOwzAQhi0EgrK8AsoFcUrwEi85cIAKSqUKBBQhcbGMF0hJmmKnon17HFrKlbl4ZH__ePQBkCCYoVhnkwwRRlNMaZFhiFAGcwhRttgCvc3DNuhBAosUIsb3wH4Ik4hwgvEu2MMY8jyHvAey4dRVqq5V2_hlYspgVbAhaVzSvttkprxq35e-KU3yVqmpOQQ7TlXBHq3PA_B0fTXu36Sju8GwfzFKdS4YSg1i2lJSaKZczo0TjjGFoSmMMhrBeGmJE1pZB40WBRaMUIMRKl41EVoLcgBOV3Nnvvmc29DKugzaVnEH28yDLCBlvEA5iqRYkdo3IXjr5MyXtfJLiaDsZMmJ7JzIzonsZMkfWXIRo8frT-avtTWb4K-dCJysARW0qpxXU12GPy7ngkJBI3e-4r7Kyi7_vYC8GT52Xcynq3wZWrvY5JX_kIwTTuXz7UD2L_Hg4WV8Lzn5Bl9Vk88</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>905679141</pqid></control><display><type>article</type><title>Inflammatory diseases of the parathyroid gland</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Talat, Nadia ; Diaz-Cano, Salvador ; Schulte, Klaus-Martin</creator><creatorcontrib>Talat, Nadia ; Diaz-Cano, Salvador ; Schulte, Klaus-Martin</creatorcontrib><description>Talat N, Diaz‐Cano S & Schulte K‐M
(2011) Histopathology59, 897–908
Inflammatory diseases of the parathyroid gland
Aims: Inflammatory disorders of the parathyroid gland are very rare as compared with those of other endocrine organs. The aim of this study was to provide the first systematic review of this condition.
Methods and results: A 42‐year‐old patient underwent surgery for recurrent secondary hyperparathyroidism. Histology showed hyperplastic parathyroiditis defined by a mixed inflammatory infiltrate with active germinal centres. Molecular markers revealed significant upregulation of CD68 in an ischaemic background (hypoxia‐inducible factor 1 upregulation) with mitochondrial reaction (malate dehydrogenase 2 upregulation) and hyperparathyroidism (carbonic anhydrase 4 upregulation). Our case demonstrates true intraparathyroid inflammation with terminal B‐cell differentiation. We searched PubMed, ISI Thompson and Google Scholar up to January 2011, using the terms ‘parathyroiditis’, ‘inflammation of parathyroid gland’, ‘lymphocytic infiltrate’, ‘tuberculosis of the parathyroid’, ‘sarcoidosis’, and ‘graulomatous inflammation’. Three autopsy series, 27 articles and 96 case reports with inflammatory parathyroid disorders were identified. Autopsy series showed lymphocytic infiltrates in up to 16% of all cases. The entire material reported lymphocytic infiltrates (n = 69), parathyroiditis with germinal centres (n = 15), sarcoidosis (n = 6), tuberculosis (n = 4), and other granulomatous diseases (n = 2).
Conclusions: Distinct inflammatory and granulomatous processes in the parathyroid gland are rare. Scanty lymphocytic infiltrates are common, and occur in generalized inflammatory conditions or venous congestion. We note the surprising absence of an association between histological proof of parathyroiditis and hypoparathyroidism.</description><identifier>ISSN: 0309-0167</identifier><identifier>EISSN: 1365-2559</identifier><identifier>DOI: 10.1111/j.1365-2559.2011.04001.x</identifier><identifier>PMID: 22074407</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Endocrinopathies ; Female ; Humans ; inflammation ; Inflammation - pathology ; Inflammation - physiopathology ; Investigative techniques, diagnostic techniques (general aspects) ; lymphocytic infiltrate ; Male ; Medical sciences ; Middle Aged ; Non tumoral diseases. Target tissue resistance. Benign neoplasms ; Parathyroid Diseases - pathology ; Parathyroid Diseases - physiopathology ; parathyroid gland ; parathyroiditis ; Parathyroids. Parafollicular cells. Cholecalciferol. Phosphocalcic homeostasis (diseases) ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; primary hyperparathyroidism ; Young Adult</subject><ispartof>Histopathology, 2011-11, Vol.59 (5), p.897-908</ispartof><rights>2011 Blackwell Publishing Limited</rights><rights>2015 INIST-CNRS</rights><rights>2011 Blackwell Publishing Limited.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4861-d16ce539c6af47df8f66a20d9dadc10af4e3f8caef0dc8928635d2119bc38cc83</citedby><cites>FETCH-LOGICAL-c4861-d16ce539c6af47df8f66a20d9dadc10af4e3f8caef0dc8928635d2119bc38cc83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2559.2011.04001.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2559.2011.04001.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24785085$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22074407$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Talat, Nadia</creatorcontrib><creatorcontrib>Diaz-Cano, Salvador</creatorcontrib><creatorcontrib>Schulte, Klaus-Martin</creatorcontrib><title>Inflammatory diseases of the parathyroid gland</title><title>Histopathology</title><addtitle>Histopathology</addtitle><description>Talat N, Diaz‐Cano S & Schulte K‐M
(2011) Histopathology59, 897–908
Inflammatory diseases of the parathyroid gland
Aims: Inflammatory disorders of the parathyroid gland are very rare as compared with those of other endocrine organs. The aim of this study was to provide the first systematic review of this condition.
Methods and results: A 42‐year‐old patient underwent surgery for recurrent secondary hyperparathyroidism. Histology showed hyperplastic parathyroiditis defined by a mixed inflammatory infiltrate with active germinal centres. Molecular markers revealed significant upregulation of CD68 in an ischaemic background (hypoxia‐inducible factor 1 upregulation) with mitochondrial reaction (malate dehydrogenase 2 upregulation) and hyperparathyroidism (carbonic anhydrase 4 upregulation). Our case demonstrates true intraparathyroid inflammation with terminal B‐cell differentiation. We searched PubMed, ISI Thompson and Google Scholar up to January 2011, using the terms ‘parathyroiditis’, ‘inflammation of parathyroid gland’, ‘lymphocytic infiltrate’, ‘tuberculosis of the parathyroid’, ‘sarcoidosis’, and ‘graulomatous inflammation’. Three autopsy series, 27 articles and 96 case reports with inflammatory parathyroid disorders were identified. Autopsy series showed lymphocytic infiltrates in up to 16% of all cases. The entire material reported lymphocytic infiltrates (n = 69), parathyroiditis with germinal centres (n = 15), sarcoidosis (n = 6), tuberculosis (n = 4), and other granulomatous diseases (n = 2).
Conclusions: Distinct inflammatory and granulomatous processes in the parathyroid gland are rare. Scanty lymphocytic infiltrates are common, and occur in generalized inflammatory conditions or venous congestion. We note the surprising absence of an association between histological proof of parathyroiditis and hypoparathyroidism.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Humans</subject><subject>inflammation</subject><subject>Inflammation - pathology</subject><subject>Inflammation - physiopathology</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>lymphocytic infiltrate</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Non tumoral diseases. Target tissue resistance. Benign neoplasms</subject><subject>Parathyroid Diseases - pathology</subject><subject>Parathyroid Diseases - physiopathology</subject><subject>parathyroid gland</subject><subject>parathyroiditis</subject><subject>Parathyroids. Parafollicular cells. Cholecalciferol. Phosphocalcic homeostasis (diseases)</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>primary hyperparathyroidism</subject><subject>Young Adult</subject><issn>0309-0167</issn><issn>1365-2559</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMlOwzAQhi0EgrK8AsoFcUrwEi85cIAKSqUKBBQhcbGMF0hJmmKnon17HFrKlbl4ZH__ePQBkCCYoVhnkwwRRlNMaZFhiFAGcwhRttgCvc3DNuhBAosUIsb3wH4Ik4hwgvEu2MMY8jyHvAey4dRVqq5V2_hlYspgVbAhaVzSvttkprxq35e-KU3yVqmpOQQ7TlXBHq3PA_B0fTXu36Sju8GwfzFKdS4YSg1i2lJSaKZczo0TjjGFoSmMMhrBeGmJE1pZB40WBRaMUIMRKl41EVoLcgBOV3Nnvvmc29DKugzaVnEH28yDLCBlvEA5iqRYkdo3IXjr5MyXtfJLiaDsZMmJ7JzIzonsZMkfWXIRo8frT-avtTWb4K-dCJysARW0qpxXU12GPy7ngkJBI3e-4r7Kyi7_vYC8GT52Xcynq3wZWrvY5JX_kIwTTuXz7UD2L_Hg4WV8Lzn5Bl9Vk88</recordid><startdate>201111</startdate><enddate>201111</enddate><creator>Talat, Nadia</creator><creator>Diaz-Cano, Salvador</creator><creator>Schulte, Klaus-Martin</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201111</creationdate><title>Inflammatory diseases of the parathyroid gland</title><author>Talat, Nadia ; Diaz-Cano, Salvador ; Schulte, Klaus-Martin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4861-d16ce539c6af47df8f66a20d9dadc10af4e3f8caef0dc8928635d2119bc38cc83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Humans</topic><topic>inflammation</topic><topic>Inflammation - pathology</topic><topic>Inflammation - physiopathology</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>lymphocytic infiltrate</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Non tumoral diseases. Target tissue resistance. Benign neoplasms</topic><topic>Parathyroid Diseases - pathology</topic><topic>Parathyroid Diseases - physiopathology</topic><topic>parathyroid gland</topic><topic>parathyroiditis</topic><topic>Parathyroids. Parafollicular cells. Cholecalciferol. Phosphocalcic homeostasis (diseases)</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>primary hyperparathyroidism</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Talat, Nadia</creatorcontrib><creatorcontrib>Diaz-Cano, Salvador</creatorcontrib><creatorcontrib>Schulte, Klaus-Martin</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Histopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Talat, Nadia</au><au>Diaz-Cano, Salvador</au><au>Schulte, Klaus-Martin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inflammatory diseases of the parathyroid gland</atitle><jtitle>Histopathology</jtitle><addtitle>Histopathology</addtitle><date>2011-11</date><risdate>2011</risdate><volume>59</volume><issue>5</issue><spage>897</spage><epage>908</epage><pages>897-908</pages><issn>0309-0167</issn><eissn>1365-2559</eissn><abstract>Talat N, Diaz‐Cano S & Schulte K‐M
(2011) Histopathology59, 897–908
Inflammatory diseases of the parathyroid gland
Aims: Inflammatory disorders of the parathyroid gland are very rare as compared with those of other endocrine organs. The aim of this study was to provide the first systematic review of this condition.
Methods and results: A 42‐year‐old patient underwent surgery for recurrent secondary hyperparathyroidism. Histology showed hyperplastic parathyroiditis defined by a mixed inflammatory infiltrate with active germinal centres. Molecular markers revealed significant upregulation of CD68 in an ischaemic background (hypoxia‐inducible factor 1 upregulation) with mitochondrial reaction (malate dehydrogenase 2 upregulation) and hyperparathyroidism (carbonic anhydrase 4 upregulation). Our case demonstrates true intraparathyroid inflammation with terminal B‐cell differentiation. We searched PubMed, ISI Thompson and Google Scholar up to January 2011, using the terms ‘parathyroiditis’, ‘inflammation of parathyroid gland’, ‘lymphocytic infiltrate’, ‘tuberculosis of the parathyroid’, ‘sarcoidosis’, and ‘graulomatous inflammation’. Three autopsy series, 27 articles and 96 case reports with inflammatory parathyroid disorders were identified. Autopsy series showed lymphocytic infiltrates in up to 16% of all cases. The entire material reported lymphocytic infiltrates (n = 69), parathyroiditis with germinal centres (n = 15), sarcoidosis (n = 6), tuberculosis (n = 4), and other granulomatous diseases (n = 2).
Conclusions: Distinct inflammatory and granulomatous processes in the parathyroid gland are rare. Scanty lymphocytic infiltrates are common, and occur in generalized inflammatory conditions or venous congestion. We note the surprising absence of an association between histological proof of parathyroiditis and hypoparathyroidism.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>22074407</pmid><doi>10.1111/j.1365-2559.2011.04001.x</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0309-0167 |
| ispartof | Histopathology, 2011-11, Vol.59 (5), p.897-908 |
| issn | 0309-0167 1365-2559 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_905679141 |
| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Adult Aged Biological and medical sciences Endocrinopathies Female Humans inflammation Inflammation - pathology Inflammation - physiopathology Investigative techniques, diagnostic techniques (general aspects) lymphocytic infiltrate Male Medical sciences Middle Aged Non tumoral diseases. Target tissue resistance. Benign neoplasms Parathyroid Diseases - pathology Parathyroid Diseases - physiopathology parathyroid gland parathyroiditis Parathyroids. Parafollicular cells. Cholecalciferol. Phosphocalcic homeostasis (diseases) Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques primary hyperparathyroidism Young Adult |
| title | Inflammatory diseases of the parathyroid gland |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T16%3A59%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Inflammatory%20diseases%20of%20the%20parathyroid%20gland&rft.jtitle=Histopathology&rft.au=Talat,%20Nadia&rft.date=2011-11&rft.volume=59&rft.issue=5&rft.spage=897&rft.epage=908&rft.pages=897-908&rft.issn=0309-0167&rft.eissn=1365-2559&rft_id=info:doi/10.1111/j.1365-2559.2011.04001.x&rft_dat=%3Cproquest_cross%3E905679141%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=905679141&rft_id=info:pmid/22074407&rfr_iscdi=true |