A facile preparation method of a PFC-containing nano-sized emulsion for theranostics of solid tumors
Theranostics means a therapy conducted in a diagnosis-guided manner. For theranostics of solid tumors by means of ultrasound, we designed a nano-sized emulsion containing perfluoropentane (PFC5). This emulsion can be delivered into tumor tissues through the tumor vasculatures owing to its nano-size,...
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Veröffentlicht in: | International journal of pharmaceutics 2011-12, Vol.421 (2), p.379-387 |
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container_title | International journal of pharmaceutics |
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creator | Shiraishi, Kouichi Endoh, Reiko Furuhata, Hiroshi Nishihara, Masamichi Suzuki, Ryo Maruyama, Kazuo Oda, Yusuke Jo, Jun-ichiro Tabata, Yasuhiko Yamamoto, Jun Yokoyama, Masayuki |
description | Theranostics means a therapy conducted in a diagnosis-guided manner. For theranostics of solid tumors by means of ultrasound, we designed a nano-sized emulsion containing perfluoropentane (PFC5). This emulsion can be delivered into tumor tissues through the tumor vasculatures owing to its nano-size, and the emulsion is transformed into a micron-sized bubble upon sonication through phase transition of PFC5. The micron-sized bubbles can more efficiently absorb ultrasonic energy for better diagnostic images and can exhibit more efficient ultrasound-driven therapeutic effects than nano-sized bubbles. For more efficient tumor delivery, smaller size is preferable, yet the preparation of a smaller emulsion is technically more difficult. In this paper, we used a bath-type sonicator to successfully obtain small PFC5-containing emulsions in a diameter of ca. 200nm. Additionally, we prepared these small emulsions at 40°C, which is above the boiling temperature of PFC5. Accordingly, we succeeded in obtaining very small nano-emulsions for theranostics through a very facile method. |
doi_str_mv | 10.1016/j.ijpharm.2011.10.006 |
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For theranostics of solid tumors by means of ultrasound, we designed a nano-sized emulsion containing perfluoropentane (PFC5). This emulsion can be delivered into tumor tissues through the tumor vasculatures owing to its nano-size, and the emulsion is transformed into a micron-sized bubble upon sonication through phase transition of PFC5. The micron-sized bubbles can more efficiently absorb ultrasonic energy for better diagnostic images and can exhibit more efficient ultrasound-driven therapeutic effects than nano-sized bubbles. For more efficient tumor delivery, smaller size is preferable, yet the preparation of a smaller emulsion is technically more difficult. In this paper, we used a bath-type sonicator to successfully obtain small PFC5-containing emulsions in a diameter of ca. 200nm. Additionally, we prepared these small emulsions at 40°C, which is above the boiling temperature of PFC5. Accordingly, we succeeded in obtaining very small nano-emulsions for theranostics through a very facile method.</description><identifier>ISSN: 0378-5173</identifier><identifier>EISSN: 1873-3476</identifier><identifier>DOI: 10.1016/j.ijpharm.2011.10.006</identifier><identifier>PMID: 22023827</identifier><identifier>CODEN: IJPHDE</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animals ; Biological and medical sciences ; boiling ; bubbles ; Drug Compounding ; Emulsion ; Emulsions ; energy ; Female ; Fluorocarbons - blood ; Fluorocarbons - chemistry ; Fluorocarbons - pharmacokinetics ; General pharmacology ; Medical sciences ; Mice ; Mice, Inbred BALB C ; nanoemulsions ; Nanoparticles - chemistry ; neoplasms ; Neoplasms - diagnosis ; Neoplasms - drug therapy ; Particle Size ; Perfluorocarbon ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; phase transition ; Polyethylene Glycols - chemistry ; Polyethylene Glycols - pharmacokinetics ; Sonication ; temperature ; Theranostics ; therapeutics ; Tumor targeting ; ultrasonics ; Ultrasound</subject><ispartof>International journal of pharmaceutics, 2011-12, Vol.421 (2), p.379-387</ispartof><rights>2011 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier B.V. 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For theranostics of solid tumors by means of ultrasound, we designed a nano-sized emulsion containing perfluoropentane (PFC5). This emulsion can be delivered into tumor tissues through the tumor vasculatures owing to its nano-size, and the emulsion is transformed into a micron-sized bubble upon sonication through phase transition of PFC5. The micron-sized bubbles can more efficiently absorb ultrasonic energy for better diagnostic images and can exhibit more efficient ultrasound-driven therapeutic effects than nano-sized bubbles. For more efficient tumor delivery, smaller size is preferable, yet the preparation of a smaller emulsion is technically more difficult. In this paper, we used a bath-type sonicator to successfully obtain small PFC5-containing emulsions in a diameter of ca. 200nm. Additionally, we prepared these small emulsions at 40°C, which is above the boiling temperature of PFC5. Accordingly, we succeeded in obtaining very small nano-emulsions for theranostics through a very facile method.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>boiling</subject><subject>bubbles</subject><subject>Drug Compounding</subject><subject>Emulsion</subject><subject>Emulsions</subject><subject>energy</subject><subject>Female</subject><subject>Fluorocarbons - blood</subject><subject>Fluorocarbons - chemistry</subject><subject>Fluorocarbons - pharmacokinetics</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>nanoemulsions</subject><subject>Nanoparticles - chemistry</subject><subject>neoplasms</subject><subject>Neoplasms - diagnosis</subject><subject>Neoplasms - drug therapy</subject><subject>Particle Size</subject><subject>Perfluorocarbon</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>phase transition</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Polyethylene Glycols - pharmacokinetics</subject><subject>Sonication</subject><subject>temperature</subject><subject>Theranostics</subject><subject>therapeutics</subject><subject>Tumor targeting</subject><subject>ultrasonics</subject><subject>Ultrasound</subject><issn>0378-5173</issn><issn>1873-3476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtv1DAURi0EokPhJwDeIFYZ7Pg5K1SNaEGqBBJ0bTn2TcejJA62g1R-PY5mKEtWlq7Pdx8HodeUbCmh8sNxG47zwaZx2xJKa21LiHyCNlQr1jCu5FO0IUzpRlDFLtCLnI-kEi1lz9FF25KW6VZtkL_CvXVhADwnmG2yJcQJj1AO0ePYY4u_Xe8bF6diwxSmezzZKTY5_AaPYVyGvOJ9TLgcINWvXILLazDHIXhcljGm_BI96-2Q4dX5vUR3159-7D83t19vvuyvbhvHNS8NCEo9kaLnHbhOOSZ3XDlQVnJNmFSk7zog1HrNiWVccrprrfBeM8_qZZpdovenvnOKPxfIxYwhOxgGO0FcstkRIZXWWlRSnEiXYs4JejOnMNr0YCgxq19zNGe_ZvW7lqu9mntznrB0I_jH1F-hFXh3Bmx2duirExfyP060mgq-rvr2xPU2GnufKnP3vU4ShNCWS0Yr8fFEQDX2K0Ay2QWYHPiQwBXjY_jPsn8AmTukxw</recordid><startdate>20111215</startdate><enddate>20111215</enddate><creator>Shiraishi, Kouichi</creator><creator>Endoh, Reiko</creator><creator>Furuhata, Hiroshi</creator><creator>Nishihara, Masamichi</creator><creator>Suzuki, Ryo</creator><creator>Maruyama, Kazuo</creator><creator>Oda, Yusuke</creator><creator>Jo, Jun-ichiro</creator><creator>Tabata, Yasuhiko</creator><creator>Yamamoto, Jun</creator><creator>Yokoyama, Masayuki</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20111215</creationdate><title>A facile preparation method of a PFC-containing nano-sized emulsion for theranostics of solid tumors</title><author>Shiraishi, Kouichi ; Endoh, Reiko ; Furuhata, Hiroshi ; Nishihara, Masamichi ; Suzuki, Ryo ; Maruyama, Kazuo ; Oda, Yusuke ; Jo, Jun-ichiro ; Tabata, Yasuhiko ; Yamamoto, Jun ; Yokoyama, Masayuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c484t-e511d065f4becb7c36947ce7a64803670fbbe01ad840a3464192a5dd83d306283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>boiling</topic><topic>bubbles</topic><topic>Drug Compounding</topic><topic>Emulsion</topic><topic>Emulsions</topic><topic>energy</topic><topic>Female</topic><topic>Fluorocarbons - blood</topic><topic>Fluorocarbons - chemistry</topic><topic>Fluorocarbons - pharmacokinetics</topic><topic>General pharmacology</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>nanoemulsions</topic><topic>Nanoparticles - chemistry</topic><topic>neoplasms</topic><topic>Neoplasms - diagnosis</topic><topic>Neoplasms - drug therapy</topic><topic>Particle Size</topic><topic>Perfluorocarbon</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>phase transition</topic><topic>Polyethylene Glycols - chemistry</topic><topic>Polyethylene Glycols - pharmacokinetics</topic><topic>Sonication</topic><topic>temperature</topic><topic>Theranostics</topic><topic>therapeutics</topic><topic>Tumor targeting</topic><topic>ultrasonics</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shiraishi, Kouichi</creatorcontrib><creatorcontrib>Endoh, Reiko</creatorcontrib><creatorcontrib>Furuhata, Hiroshi</creatorcontrib><creatorcontrib>Nishihara, Masamichi</creatorcontrib><creatorcontrib>Suzuki, Ryo</creatorcontrib><creatorcontrib>Maruyama, Kazuo</creatorcontrib><creatorcontrib>Oda, Yusuke</creatorcontrib><creatorcontrib>Jo, Jun-ichiro</creatorcontrib><creatorcontrib>Tabata, Yasuhiko</creatorcontrib><creatorcontrib>Yamamoto, Jun</creatorcontrib><creatorcontrib>Yokoyama, Masayuki</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of pharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shiraishi, Kouichi</au><au>Endoh, Reiko</au><au>Furuhata, Hiroshi</au><au>Nishihara, Masamichi</au><au>Suzuki, Ryo</au><au>Maruyama, Kazuo</au><au>Oda, Yusuke</au><au>Jo, Jun-ichiro</au><au>Tabata, Yasuhiko</au><au>Yamamoto, Jun</au><au>Yokoyama, Masayuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A facile preparation method of a PFC-containing nano-sized emulsion for theranostics of solid tumors</atitle><jtitle>International journal of pharmaceutics</jtitle><addtitle>Int J Pharm</addtitle><date>2011-12-15</date><risdate>2011</risdate><volume>421</volume><issue>2</issue><spage>379</spage><epage>387</epage><pages>379-387</pages><issn>0378-5173</issn><eissn>1873-3476</eissn><coden>IJPHDE</coden><abstract>Theranostics means a therapy conducted in a diagnosis-guided manner. For theranostics of solid tumors by means of ultrasound, we designed a nano-sized emulsion containing perfluoropentane (PFC5). This emulsion can be delivered into tumor tissues through the tumor vasculatures owing to its nano-size, and the emulsion is transformed into a micron-sized bubble upon sonication through phase transition of PFC5. The micron-sized bubbles can more efficiently absorb ultrasonic energy for better diagnostic images and can exhibit more efficient ultrasound-driven therapeutic effects than nano-sized bubbles. For more efficient tumor delivery, smaller size is preferable, yet the preparation of a smaller emulsion is technically more difficult. In this paper, we used a bath-type sonicator to successfully obtain small PFC5-containing emulsions in a diameter of ca. 200nm. Additionally, we prepared these small emulsions at 40°C, which is above the boiling temperature of PFC5. Accordingly, we succeeded in obtaining very small nano-emulsions for theranostics through a very facile method.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>22023827</pmid><doi>10.1016/j.ijpharm.2011.10.006</doi><tpages>9</tpages></addata></record> |
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subjects | Animals Biological and medical sciences boiling bubbles Drug Compounding Emulsion Emulsions energy Female Fluorocarbons - blood Fluorocarbons - chemistry Fluorocarbons - pharmacokinetics General pharmacology Medical sciences Mice Mice, Inbred BALB C nanoemulsions Nanoparticles - chemistry neoplasms Neoplasms - diagnosis Neoplasms - drug therapy Particle Size Perfluorocarbon Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments phase transition Polyethylene Glycols - chemistry Polyethylene Glycols - pharmacokinetics Sonication temperature Theranostics therapeutics Tumor targeting ultrasonics Ultrasound |
title | A facile preparation method of a PFC-containing nano-sized emulsion for theranostics of solid tumors |
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