Association of VKORC1 −1639 G > A polymorphism with carotid intima–media thickness in type 2 diabetes mellitus

Abstract Aims Media calcification is a predictor of cardiovascular mortality in type 2 diabetes mellitus (T2DM). Undercarboxylation of some vitamin K-dependent proteins, due to genetic polymorphisms of VKORC1 , can lead to calcification. We examined a potential association between VKORC1 −1639 G >...

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Veröffentlicht in:	Diabetes research and clinical practice 2011-11, Vol.94 (2), p.236-241
Hauptverfasser:	Tavridou, Anna, Petridis, Ioannis, Vasileiadis, Michail, Ragia, Georgia, Heliopoulos, Ioannis, Vargemezis, Vassileios, Manolopoulos, Vangelis G
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Analysis of Variance Atherosclerosis Calcification Carotid Arteries - diagnostic imaging Carotid Artery Diseases - diagnostic imaging Carotid Artery Diseases - enzymology Carotid Artery Diseases - genetics Carotid intima–media thickness Case-Control Studies Chi-Square Distribution Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - enzymology Diabetes Mellitus, Type 2 - genetics Diabetic Angiopathies - diagnostic imaging Diabetic Angiopathies - enzymology Diabetic Angiopathies - genetics Endocrinology & Metabolism Female Gene Frequency Genetic Predisposition to Disease Greece Humans Logistic Models Male Middle Aged Mixed Function Oxygenases - genetics Odds Ratio Phenotype Polymerase Chain Reaction Polymorphism, Genetic Risk Assessment Risk Factors Tunica Intima - diagnostic imaging Tunica Media - diagnostic imaging Type 2 diabetes mellitus Ultrasonography Vascular Calcification - diagnostic imaging Vascular Calcification - enzymology Vascular Calcification - genetics Vitamin K Epoxide Reductases VKORC1 −1639 G > A polymorphism
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