$Aqueous fraction from Costus spiralis (Jacq.) Roscoe leaf reduces contractility by impairing the calcium inward current in the mammalian myocardium$

Aqueous fraction from Costus spiralis (Jacq.) Roscoe leaf reduces contractility by impairing the calcium inward current in the mammalian myocardium

AqF from Costus spiralis reduces the calcium entry in myocardial cells as showed by its effect on the Bowditch phenomenon and on the positive inotropic effect produced by both BAY K8644 and isoproterenol. Direct measurements of the L-type calcium current (ICa, L) as well as of the intracellular free...

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Veröffentlicht in:	Journal of ethnopharmacology 2011-11, Vol.138 (2), p.382-389
Hauptverfasser:	Britto, Raquel Moreira, Santos, André Luiz, Cruz, Jader Santos, Gondim, Antonio Nei Santana, Lauton-Santos, Sandra, Lara, Aline, Guatimosim, Silvia, Vasconcelos, Carla Maria Lins, Estevam, Charles dos Santos, Dias, Antonio Santos, Oliveira, Evaleide Diniz, Lima, Adriana Karla, Souza, Rejane Cardoso, Conde-Garcia, Eduardo Antonio
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester - pharmacology Animals Atropine Biological and medical sciences Calcium Calcium (intracellular) Calcium Channels, L-Type - drug effects Calcium currents Cardiac arrhythmias cardiomyocytes Contractility Costus Costus - chemistry Costus spiralis Data processing Ethyl acetate Flavones Flavonoids General pharmacology Guinea Pigs Heart In Vitro Techniques isoproterenol Isoproterenol - pharmacology Leaves Male Medical sciences Medicinal plants Mice Mice, Inbred C57BL Muscle contraction Myocardial Contraction - drug effects Myocardium Patch-Clamp Techniques Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phenols Plant Extracts - pharmacology Potassium Sodium Tannic acid Tetraethylammonium
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