Correlation between mammographic findings and corresponding histopathology: Potential predictors for biological characteristics of breast diseases
The present study retrospectively evaluated the mammographic findings of 606 Japanese women with breast cancer (median age 50 years; range 27–89 years) and correlated them with histopathological characteristics. Mammographic findings were evaluated with an emphasis on mass shape, margin, density, ca...
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| Veröffentlicht in: | Cancer science 2011-12, Vol.102 (12), p.2179-2185 |
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| creator | Tamaki, Kentaro Ishida, Takanori Miyashita, Minoru Amari, Masakazu Ohuchi, Noriaki Tamaki, Nobumitsu Sasano, Hironobu |
| description | The present study retrospectively evaluated the mammographic findings of 606 Japanese women with breast cancer (median age 50 years; range 27–89 years) and correlated them with histopathological characteristics. Mammographic findings were evaluated with an emphasis on mass shape, margin, density, calcification, and the presence of architectural distortion; these findings were correlated with histopathological characteristics such as intrinsic subtype, histological grade, lymphovascular invasion, and the Ki‐67 labeling index. An irregular mass shape and masses with a spiculated margin were significantly higher in the group of patients with luminal A breast cancer than in patients with masses that were lobular or round, or in tumors with an indistinct or microlobulated periphery (P = 0.017, P = 0.024, P |
| doi_str_mv | 10.1111/j.1349-7006.2011.02088.x |
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Mammographic findings were evaluated with an emphasis on mass shape, margin, density, calcification, and the presence of architectural distortion; these findings were correlated with histopathological characteristics such as intrinsic subtype, histological grade, lymphovascular invasion, and the Ki‐67 labeling index. An irregular mass shape and masses with a spiculated margin were significantly higher in the group of patients with luminal A breast cancer than in patients with masses that were lobular or round, or in tumors with an indistinct or microlobulated periphery (P = 0.017, P = 0.024, P < 0.001, and P = 0.001, respectively). Irregular mass shape and spiculated periphery were significantly lower in patients with Grade 3 cancer (P < 0.001 for both). In terms of lymphovascular invasion, there were significant differences between oval and irregular or round mass shape (P = 0.008 and P = 0.034), between tumors with a microlobulated and indistinct periphery (P = 0.014), between tumors with a punctate and amorphous or pleomorphic calcification shape (P = 0.030 and 0.038), and between the presence and absence of architectural distortion (P = 0.027). Equivalent or low‐density masses were also higher in Grade 1 breast cancers (P = 0.007). There were significant differences in the Ki‐67 labeling index between irregular and lobular or round tumors (P < 0.001 and P = 0.014), as well as between spiculated and indistinct or microlobulated tumors (P < 0.001 for both). Significant differences were noted in the mammographic features of different primary breast cancer subtypes. These proposed mammographic diagnostic criteria based on biological characteristics may contribute to a more accurate prediction of biological behavior of breast malignancies. 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Mammographic findings were evaluated with an emphasis on mass shape, margin, density, calcification, and the presence of architectural distortion; these findings were correlated with histopathological characteristics such as intrinsic subtype, histological grade, lymphovascular invasion, and the Ki‐67 labeling index. An irregular mass shape and masses with a spiculated margin were significantly higher in the group of patients with luminal A breast cancer than in patients with masses that were lobular or round, or in tumors with an indistinct or microlobulated periphery (P = 0.017, P = 0.024, P < 0.001, and P = 0.001, respectively). Irregular mass shape and spiculated periphery were significantly lower in patients with Grade 3 cancer (P < 0.001 for both). In terms of lymphovascular invasion, there were significant differences between oval and irregular or round mass shape (P = 0.008 and P = 0.034), between tumors with a microlobulated and indistinct periphery (P = 0.014), between tumors with a punctate and amorphous or pleomorphic calcification shape (P = 0.030 and 0.038), and between the presence and absence of architectural distortion (P = 0.027). Equivalent or low‐density masses were also higher in Grade 1 breast cancers (P = 0.007). There were significant differences in the Ki‐67 labeling index between irregular and lobular or round tumors (P < 0.001 and P = 0.014), as well as between spiculated and indistinct or microlobulated tumors (P < 0.001 for both). Significant differences were noted in the mammographic features of different primary breast cancer subtypes. These proposed mammographic diagnostic criteria based on biological characteristics may contribute to a more accurate prediction of biological behavior of breast malignancies. (Cancer Sci 2011; 102: 2179–2185)</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor</subject><subject>Breast - pathology</subject><subject>Breast Neoplasms - diagnostic imaging</subject><subject>Breast Neoplasms - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Japan</subject><subject>Ki-67 Antigen</subject><subject>Mammography</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Grading</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Tumors</subject><issn>1347-9032</issn><issn>1349-7006</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1v1DAQhiMEoh_wF5AviFPC2M6HjcShWhWKVIlKhbPlOJNdr5I42F61-zf6i3F2l_aKD56R55kZ632zjFAoaDqftwXlpcwbgLpgQGkBDIQoHl9l58-F14e8ySVwdpZdhLAF4HUpy7fZGaNCVqKW59nTynmPg47WTaTF-IA4kVGPo1t7PW-sIb2dOjutA9FTR8xCh9kdnsjGhuhmHTducOv9F3LnIk7R6oHMHjtrovOB9M6T1i6ENaliNtprE9GnXmsCcT1pPeoQSWdDihjeZW96PQR8f4qX2e9v179WN_ntz-8_Vle3uanqRuTMVJLKGqEzWggmki5tDVIYKPtWtMC1hkZQzlpGZSPrDpuy7HnD0sUTxi-zT8e5s3d_dhiiGm0wOAx6QrcLSsKyp-KQSHEkjXcheOzV7O2o_V5RUIshaqsW3dWiu1oMUQdD1GNq_XBasmtH7J4b_zmQgI8nQIekT-_1ZGx44aoSSlaJxH09cg92wP1_f0Ctru6XjP8FOZ6p8A</recordid><startdate>201112</startdate><enddate>201112</enddate><creator>Tamaki, Kentaro</creator><creator>Ishida, Takanori</creator><creator>Miyashita, Minoru</creator><creator>Amari, Masakazu</creator><creator>Ohuchi, Noriaki</creator><creator>Tamaki, Nobumitsu</creator><creator>Sasano, Hironobu</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201112</creationdate><title>Correlation between mammographic findings and corresponding histopathology: Potential predictors for biological characteristics of breast diseases</title><author>Tamaki, Kentaro ; Ishida, Takanori ; Miyashita, Minoru ; Amari, Masakazu ; Ohuchi, Noriaki ; Tamaki, Nobumitsu ; Sasano, Hironobu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5678-2c59196e0dca8828111b6098c04fb8b03aa078132b219796de744f3724f3398c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor</topic><topic>Breast - pathology</topic><topic>Breast Neoplasms - diagnostic imaging</topic><topic>Breast Neoplasms - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Japan</topic><topic>Ki-67 Antigen</topic><topic>Mammography</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Grading</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tamaki, Kentaro</creatorcontrib><creatorcontrib>Ishida, Takanori</creatorcontrib><creatorcontrib>Miyashita, Minoru</creatorcontrib><creatorcontrib>Amari, Masakazu</creatorcontrib><creatorcontrib>Ohuchi, Noriaki</creatorcontrib><creatorcontrib>Tamaki, Nobumitsu</creatorcontrib><creatorcontrib>Sasano, Hironobu</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Tamaki, Kentaro</au><au>Ishida, Takanori</au><au>Miyashita, Minoru</au><au>Amari, Masakazu</au><au>Ohuchi, Noriaki</au><au>Tamaki, Nobumitsu</au><au>Sasano, Hironobu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation between mammographic findings and corresponding histopathology: Potential predictors for biological characteristics of breast diseases</atitle><jtitle>Cancer science</jtitle><addtitle>Cancer Sci</addtitle><date>2011-12</date><risdate>2011</risdate><volume>102</volume><issue>12</issue><spage>2179</spage><epage>2185</epage><pages>2179-2185</pages><issn>1347-9032</issn><eissn>1349-7006</eissn><abstract>The present study retrospectively evaluated the mammographic findings of 606 Japanese women with breast cancer (median age 50 years; range 27–89 years) and correlated them with histopathological characteristics. Mammographic findings were evaluated with an emphasis on mass shape, margin, density, calcification, and the presence of architectural distortion; these findings were correlated with histopathological characteristics such as intrinsic subtype, histological grade, lymphovascular invasion, and the Ki‐67 labeling index. An irregular mass shape and masses with a spiculated margin were significantly higher in the group of patients with luminal A breast cancer than in patients with masses that were lobular or round, or in tumors with an indistinct or microlobulated periphery (P = 0.017, P = 0.024, P < 0.001, and P = 0.001, respectively). Irregular mass shape and spiculated periphery were significantly lower in patients with Grade 3 cancer (P < 0.001 for both). In terms of lymphovascular invasion, there were significant differences between oval and irregular or round mass shape (P = 0.008 and P = 0.034), between tumors with a microlobulated and indistinct periphery (P = 0.014), between tumors with a punctate and amorphous or pleomorphic calcification shape (P = 0.030 and 0.038), and between the presence and absence of architectural distortion (P = 0.027). Equivalent or low‐density masses were also higher in Grade 1 breast cancers (P = 0.007). There were significant differences in the Ki‐67 labeling index between irregular and lobular or round tumors (P < 0.001 and P = 0.014), as well as between spiculated and indistinct or microlobulated tumors (P < 0.001 for both). Significant differences were noted in the mammographic features of different primary breast cancer subtypes. These proposed mammographic diagnostic criteria based on biological characteristics may contribute to a more accurate prediction of biological behavior of breast malignancies. (Cancer Sci 2011; 102: 2179–2185)</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21895869</pmid><doi>10.1111/j.1349-7006.2011.02088.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Biomarkers, Tumor Breast - pathology Breast Neoplasms - diagnostic imaging Breast Neoplasms - pathology Female Humans Japan Ki-67 Antigen Mammography Medical sciences Middle Aged Neoplasm Grading Prognosis Retrospective Studies Tumors |
| title | Correlation between mammographic findings and corresponding histopathology: Potential predictors for biological characteristics of breast diseases |
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