The effect of CTLA-4Ig, a CD28/B7 antagonist, on the lung inflammation and T cell subset profile during murine hypersensitivity pneumonitis

Hypersensitivity pneumonitis (HP) is an inflammatory lung disease characterized by an influx of activated T cells to the lung, in which the CD28/B7 costimulatory signals are essential for the T cell activation and the outcome of the inflammatory response. In this study, we investigated the effect of...

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Veröffentlicht in:	Experimental and molecular pathology 2011-12, Vol.91 (3), p.718-722
Hauptverfasser:	Jiménez-Alvarez, Luis, Arreola, José Luis, Ramírez-Martínez, Gustavo, Ortiz-Quintero, Blanca, Gaxiola, Miguel, Reynoso-Robles, Rafael, Avila-Moreno, Federico, Urrea, Francisco, Pardo, Annie, Selman, Moisés, Zuñiga, Joaquín
Format:	Artikel
Sprache:	eng
Schlagworte:	Abatacept Alveolitis, Extrinsic Allergic - drug therapy Alveolitis, Extrinsic Allergic - immunology Animals B7 Antigens - antagonists & inhibitors B7 Antigens - immunology Biological and medical sciences CD28 Antigens - antagonists & inhibitors CD28 Antigens - immunology Chemical and industrial products toxicology. Toxic occupational diseases CTLA-4Ig Disease Progression Female Hypersensitivity pneumonitis Immunoconjugates - pharmacology Immunophenotyping Immunosuppressive Agents - pharmacology Inflammation - drug therapy Inflammation - immunology Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.) Investigative techniques, diagnostic techniques (general aspects) Lung inflammation Medical sciences Mice Mice, Inbred C57BL Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Pneumology Respiratory system : syndromes and miscellaneous diseases T cells T-Lymphocyte Subsets - drug effects T-Lymphocyte Subsets - immunology Toxicology
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