17β-Estradiol attenuates saturated fatty acid diet-induced liver injury in ovariectomized mice by up-regulating hepatic senescence marker protein-30

► High-saturated fatty acids induce apoptotic liver injury in ovariectomized mice. ► 17β-Estradiol attenuates saturated fatty acid diet-induced apoptotic liver damage. ► 17β-Estradiol administration up-regulates hepatic senescence marker protein-30. ► Increased senescence marker protein-30 acts to p...

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Veröffentlicht in:	Biochemical and biophysical research communications 2011-11, Vol.415 (2), p.252-257
Hauptverfasser:	Fukui, Michiaki, Senmaru, Takafumi, Hasegawa, Goji, Yamazaki, Masahiro, Asano, Mai, Kagami, Yayoi, Ishigami, Akihito, Maruyama, Naoki, Iwasa, Koichi, Kitawaki, Jo, Itoh, Yoshito, Okanoue, Takeshi, Ohta, Mitsuhiro, Obayashi, Hiroshi, Nakamura, Naoto
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Animals Apoptosis Apoptosis - drug effects Calcium-Binding Proteins - biosynthesis Calcium-Binding Proteins - genetics Caspase 3 - metabolism Diet - adverse effects DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - genetics Endoplasmic reticulum stress Estradiol - administration & dosage Fatty Acids - adverse effects Fatty Liver - drug therapy Fatty Liver - etiology Female Gene Expression Intracellular Signaling Peptides and Proteins - genetics Liver - drug effects Liver - metabolism Liver - pathology Mice Mice, Inbred C57BL Non-alcoholic Fatty Liver Disease Nonalcoholic steatohepatitis Regulatory Factor X Transcription Factors Saturated fatty acids Senescence marker protein-30 Transcription Factors - biosynthesis Transcription Factors - genetics Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - genetics Up-Regulation X-Box Binding Protein 1
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