AV119, a Natural Sugar from Avocado gratissima, Modulates the LPS-Induced Proinflammatory Response in Human Keratinocytes
Keratinocytes play an active role in innate immune responses by secreting a variety of cytokines and chemokines. The release of critical proinflammatory cytokines, which are necessary to activate the immune response, is induced by the stimulation of Toll-like receptors (TLRs) by molecules present on...
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| Veröffentlicht in: | Inflammation 2011-12, Vol.34 (6), p.568-575 |
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| creator | Donnarumma, Giovanna Paoletti, Iole Buommino, Elisabetta Fusco, Alessandra Baudouin, Caroline Msika, Philippe Tufano, Maria Antonietta Baroni, Adone |
| description | Keratinocytes play an active role in innate immune responses by secreting a variety of cytokines and chemokines. The release of critical proinflammatory cytokines, which are necessary to activate the immune response, is induced by the stimulation of Toll-like receptors (TLRs) by molecules present on pathogenic micro-organisms such as lipopolysaccharide (LPS). AV119, a patented blend of avocado sugars, induced the aggregation of
Malassezia furfur
, a dimorphic, lipid-dependent yeast that is part of the normal human cutaneous commensal flora and inhibited its penetration into the keratinocytes. In the present study, the anti-inflammatory effects of AV119 were investigated in LPS-induced inflammation of human keratinocytes. In particular, we analysed the modulation of the LPS-induced expression of proinflammatory cytokines and heat shock protein 70 (HSP70) by AV119 and the involvement of TLR-4. Our data show that AV119 is able to modulate significantly the proinflammatory response in human keratinocytes, blocking the NF-kB activation in human keratinocytes. |
| doi_str_mv | 10.1007/s10753-010-9264-6 |
| format | Article |
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Malassezia furfur
, a dimorphic, lipid-dependent yeast that is part of the normal human cutaneous commensal flora and inhibited its penetration into the keratinocytes. In the present study, the anti-inflammatory effects of AV119 were investigated in LPS-induced inflammation of human keratinocytes. In particular, we analysed the modulation of the LPS-induced expression of proinflammatory cytokines and heat shock protein 70 (HSP70) by AV119 and the involvement of TLR-4. Our data show that AV119 is able to modulate significantly the proinflammatory response in human keratinocytes, blocking the NF-kB activation in human keratinocytes.</description><identifier>ISSN: 0360-3997</identifier><identifier>EISSN: 1573-2576</identifier><identifier>DOI: 10.1007/s10753-010-9264-6</identifier><identifier>PMID: 20936426</identifier><identifier>CODEN: INFLD4</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Biomedical and Life Sciences ; Biomedicine ; Carbohydrates - immunology ; Cytokines - analysis ; Heat-Shock Proteins - analysis ; Humans ; Immunity, Innate - drug effects ; Immunology ; Inflammation - drug therapy ; Internal Medicine ; Keratinocytes - drug effects ; Keratinocytes - immunology ; Keratinocytes - pathology ; Lipopolysaccharides - pharmacology ; Malassezia furfur ; NF-kappa B - immunology ; Pathology ; Persea - chemistry ; Persea - immunology ; Persea americana ; Pharmacology/Toxicology ; Rheumatology ; Toll-Like Receptor 4 - immunology</subject><ispartof>Inflammation, 2011-12, Vol.34 (6), p.568-575</ispartof><rights>Springer Science+Business Media, LLC 2010</rights><rights>Springer Science+Business Media, LLC 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-e99c9723c1c83e1535a66fa360236dd752ef181258163b12f79cc00fd8e5cd323</citedby><cites>FETCH-LOGICAL-c403t-e99c9723c1c83e1535a66fa360236dd752ef181258163b12f79cc00fd8e5cd323</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10753-010-9264-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10753-010-9264-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20936426$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Donnarumma, Giovanna</creatorcontrib><creatorcontrib>Paoletti, Iole</creatorcontrib><creatorcontrib>Buommino, Elisabetta</creatorcontrib><creatorcontrib>Fusco, Alessandra</creatorcontrib><creatorcontrib>Baudouin, Caroline</creatorcontrib><creatorcontrib>Msika, Philippe</creatorcontrib><creatorcontrib>Tufano, Maria Antonietta</creatorcontrib><creatorcontrib>Baroni, Adone</creatorcontrib><title>AV119, a Natural Sugar from Avocado gratissima, Modulates the LPS-Induced Proinflammatory Response in Human Keratinocytes</title><title>Inflammation</title><addtitle>Inflammation</addtitle><addtitle>Inflammation</addtitle><description>Keratinocytes play an active role in innate immune responses by secreting a variety of cytokines and chemokines. The release of critical proinflammatory cytokines, which are necessary to activate the immune response, is induced by the stimulation of Toll-like receptors (TLRs) by molecules present on pathogenic micro-organisms such as lipopolysaccharide (LPS). AV119, a patented blend of avocado sugars, induced the aggregation of
Malassezia furfur
, a dimorphic, lipid-dependent yeast that is part of the normal human cutaneous commensal flora and inhibited its penetration into the keratinocytes. In the present study, the anti-inflammatory effects of AV119 were investigated in LPS-induced inflammation of human keratinocytes. In particular, we analysed the modulation of the LPS-induced expression of proinflammatory cytokines and heat shock protein 70 (HSP70) by AV119 and the involvement of TLR-4. Our data show that AV119 is able to modulate significantly the proinflammatory response in human keratinocytes, blocking the NF-kB activation in human keratinocytes.</description><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Carbohydrates - immunology</subject><subject>Cytokines - analysis</subject><subject>Heat-Shock Proteins - analysis</subject><subject>Humans</subject><subject>Immunity, Innate - drug effects</subject><subject>Immunology</subject><subject>Inflammation - drug therapy</subject><subject>Internal Medicine</subject><subject>Keratinocytes - drug effects</subject><subject>Keratinocytes - immunology</subject><subject>Keratinocytes - pathology</subject><subject>Lipopolysaccharides - pharmacology</subject><subject>Malassezia furfur</subject><subject>NF-kappa B - immunology</subject><subject>Pathology</subject><subject>Persea - chemistry</subject><subject>Persea - immunology</subject><subject>Persea americana</subject><subject>Pharmacology/Toxicology</subject><subject>Rheumatology</subject><subject>Toll-Like Receptor 4 - immunology</subject><issn>0360-3997</issn><issn>1573-2576</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kc1PFDEYhxuigQX9A7yYxgseKPZj2k6PG4JCXJGIcG1K21mHzLRLOzXZ_55OFjUx0VMPfd7f-_EA8IbgU4Kx_JAJlpwhTDBSVDRI7IEF4ZIhyqV4ARaYCYyYUvIAHOb8gDFuVcv2wQHFiomGigXYLu8IUSfQwCszlWQGeFPWJsEuxREuf0ZrXITrZKY-5340J_BLdGUwk89w-uHh6voGXQZXrHfwOsU-dIMZRzPFtIXffN7EkD3sA7woownws5-DQrTbWv8KvOzMkP3r5_cI3H48_352gVZfP12eLVfINphNyCtllaTMEtsyTzjjRojO1M0oE85JTn1HWkJ5SwS7J7STylqMO9d6bh2j7Agc73I3KT4Wnyc99tn6YTDBx5K1wlzIpm1EJd__lyRNbSOokqSi7_5CH2JJoe5R85o6nBQzRHaQTTHn5Du9SfWGaasJ1rNAvROoq0A9C9TzDG-fg8v96N3vil_GKkB3QK5fYe3Tn87_Tn0CRSikTw</recordid><startdate>20111201</startdate><enddate>20111201</enddate><creator>Donnarumma, Giovanna</creator><creator>Paoletti, Iole</creator><creator>Buommino, Elisabetta</creator><creator>Fusco, Alessandra</creator><creator>Baudouin, Caroline</creator><creator>Msika, Philippe</creator><creator>Tufano, Maria Antonietta</creator><creator>Baroni, Adone</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20111201</creationdate><title>AV119, a Natural Sugar from Avocado gratissima, Modulates the LPS-Induced Proinflammatory Response in Human Keratinocytes</title><author>Donnarumma, Giovanna ; Paoletti, Iole ; Buommino, Elisabetta ; Fusco, Alessandra ; Baudouin, Caroline ; Msika, Philippe ; Tufano, Maria Antonietta ; Baroni, Adone</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-e99c9723c1c83e1535a66fa360236dd752ef181258163b12f79cc00fd8e5cd323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Carbohydrates - immunology</topic><topic>Cytokines - analysis</topic><topic>Heat-Shock Proteins - analysis</topic><topic>Humans</topic><topic>Immunity, Innate - drug effects</topic><topic>Immunology</topic><topic>Inflammation - drug therapy</topic><topic>Internal Medicine</topic><topic>Keratinocytes - drug effects</topic><topic>Keratinocytes - immunology</topic><topic>Keratinocytes - pathology</topic><topic>Lipopolysaccharides - pharmacology</topic><topic>Malassezia furfur</topic><topic>NF-kappa B - immunology</topic><topic>Pathology</topic><topic>Persea - chemistry</topic><topic>Persea - immunology</topic><topic>Persea americana</topic><topic>Pharmacology/Toxicology</topic><topic>Rheumatology</topic><topic>Toll-Like Receptor 4 - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Donnarumma, Giovanna</creatorcontrib><creatorcontrib>Paoletti, Iole</creatorcontrib><creatorcontrib>Buommino, Elisabetta</creatorcontrib><creatorcontrib>Fusco, Alessandra</creatorcontrib><creatorcontrib>Baudouin, Caroline</creatorcontrib><creatorcontrib>Msika, Philippe</creatorcontrib><creatorcontrib>Tufano, Maria Antonietta</creatorcontrib><creatorcontrib>Baroni, Adone</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Inflammation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Donnarumma, Giovanna</au><au>Paoletti, Iole</au><au>Buommino, Elisabetta</au><au>Fusco, Alessandra</au><au>Baudouin, Caroline</au><au>Msika, Philippe</au><au>Tufano, Maria Antonietta</au><au>Baroni, Adone</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>AV119, a Natural Sugar from Avocado gratissima, Modulates the LPS-Induced Proinflammatory Response in Human Keratinocytes</atitle><jtitle>Inflammation</jtitle><stitle>Inflammation</stitle><addtitle>Inflammation</addtitle><date>2011-12-01</date><risdate>2011</risdate><volume>34</volume><issue>6</issue><spage>568</spage><epage>575</epage><pages>568-575</pages><issn>0360-3997</issn><eissn>1573-2576</eissn><coden>INFLD4</coden><abstract>Keratinocytes play an active role in innate immune responses by secreting a variety of cytokines and chemokines. The release of critical proinflammatory cytokines, which are necessary to activate the immune response, is induced by the stimulation of Toll-like receptors (TLRs) by molecules present on pathogenic micro-organisms such as lipopolysaccharide (LPS). AV119, a patented blend of avocado sugars, induced the aggregation of
Malassezia furfur
, a dimorphic, lipid-dependent yeast that is part of the normal human cutaneous commensal flora and inhibited its penetration into the keratinocytes. In the present study, the anti-inflammatory effects of AV119 were investigated in LPS-induced inflammation of human keratinocytes. In particular, we analysed the modulation of the LPS-induced expression of proinflammatory cytokines and heat shock protein 70 (HSP70) by AV119 and the involvement of TLR-4. Our data show that AV119 is able to modulate significantly the proinflammatory response in human keratinocytes, blocking the NF-kB activation in human keratinocytes.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>20936426</pmid><doi>10.1007/s10753-010-9264-6</doi><tpages>8</tpages></addata></record> |
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| ispartof | Inflammation, 2011-12, Vol.34 (6), p.568-575 |
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| subjects | Biomedical and Life Sciences Biomedicine Carbohydrates - immunology Cytokines - analysis Heat-Shock Proteins - analysis Humans Immunity, Innate - drug effects Immunology Inflammation - drug therapy Internal Medicine Keratinocytes - drug effects Keratinocytes - immunology Keratinocytes - pathology Lipopolysaccharides - pharmacology Malassezia furfur NF-kappa B - immunology Pathology Persea - chemistry Persea - immunology Persea americana Pharmacology/Toxicology Rheumatology Toll-Like Receptor 4 - immunology |
| title | AV119, a Natural Sugar from Avocado gratissima, Modulates the LPS-Induced Proinflammatory Response in Human Keratinocytes |
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