Radicicol, an inhibitor of Hsp90, enhances TRAIL-induced apoptosis in human epithelial ovarian carcinoma cells by promoting activation of apoptosis-related proteins

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in various cancer cells. Hsp90 is known to be involved in cell survival and growth in tumor cells. Nevertheless, Hsp90 inhibitors exhibit a variable effect on the cytotoxicity of anticancer drugs. Furthermore, the comb...

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Veröffentlicht in:	Molecular and cellular biochemistry 2012, Vol.359 (1-2), p.33-43
Hauptverfasser:	Kim, Yun Jeong, Lee, Seon Ae, Myung, Soon Chul, Kim, Wonyong, Lee, Chung Soo
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents Apoptosis Apoptosis - drug effects Apoptosis Regulatory Proteins - drug effects Apoptosis Regulatory Proteins - metabolism BH3 Interacting Domain Death Agonist Protein - metabolism Biochemistry Biomedical and Life Sciences Cancer Carcinoma Carcinoma, Ovarian Epithelial Cardiology Caspases - metabolism Cell Line, Tumor Cells Cytochrome c Cytotoxicity Enzyme Inhibitors Female Heat shock proteins HSP90 Heat-Shock Proteins - antagonists & inhibitors Humans Life Sciences Macrolides - pharmacology Medical Biochemistry Mitochondria Mitochondrial DNA Neoplasms, Glandular and Epithelial - drug therapy Neoplasms, Glandular and Epithelial - pathology Oncology Ovarian cancer Ovarian Neoplasms - drug therapy Ovarian Neoplasms - pathology Proteins TNF-Related Apoptosis-Inducing Ligand - physiology Tumor necrosis factor Tumor proteins
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