Cannabinoid–Opioid Interaction in Chronic Pain

Cannabinoids and opioids share several pharmacologic properties and may act synergistically. The potential pharmacokinetics and the safety of the combination in humans are unknown. We therefore undertook a study to answer these questions. Twenty–one individuals with chronic pain, on a regimen of twi...

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Veröffentlicht in:	Clinical pharmacology and therapeutics 2011-12, Vol.90 (6), p.844-851
Hauptverfasser:	Abrams, D I, Couey, P, Shade, S B, Kelly, M E, Benowitz, N L
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Adult Analgesics, Opioid - administration & dosage Analgesics, Opioid - pharmacokinetics Analgesics, Opioid - therapeutic use Area Under Curve Biological and medical sciences Chronic Pain - drug therapy Delayed-Action Preparations Dronabinol - adverse effects Dronabinol - pharmacology Drug Administration Schedule Drug Synergism Female Humans Male Medical sciences Middle Aged Morphine - administration & dosage Morphine - pharmacokinetics Morphine - therapeutic use Oxycodone - administration & dosage Oxycodone - pharmacokinetics Oxycodone - therapeutic use Pharmacology. Drug treatments Treatment Outcome
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