Relevance of IgVH Gene Somatic Hypermutation and Interphase Cytogenetics in Lymphomatous Presentation of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Background. Chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) are regarded as the same entity, with SLL restricted to tissue cases featuring no leukemic phase. In this study, the authors evaluate a group of SLL cases for cytogenetic abnormalities and IgVH gene mutational status...
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| Veröffentlicht in: | International journal of surgical pathology 2011-10, Vol.19 (5), p.563-569 |
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| container_title | International journal of surgical pathology |
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| creator | Yeung, Cecilia C. S. Powers, Michelle L. E. Dung Nguyen, Tu Kreisel, Friederike Frater, John L. Zehnbauer, Barbara A. Burack, Richard Hassan, Anjum |
| description | Background. Chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) are regarded as the same entity, with SLL restricted to tissue cases featuring no leukemic phase. In this study, the authors evaluate a group of SLL cases for cytogenetic abnormalities and IgVH gene mutational status to illicit differences between CLL and SLL. Design. IgVH gene polymerase chain reaction amplification and subsequent sequencing were preformed on formalin-fixed, paraffin-embedded archival tissue of 44 patients (SLL n = 34 or CLL n = 10). Cytogenetic data, CD38, and ZAP-70 expression were also evaluated for these cases. Results. The data indicate that 9/34 (26%) SLL cases have somatic hypermutation >2%, which is less than the CLL group where 40% were mutated (4/10). Cytogenetic abnormalities were seen in 58% of the SLL cases with many showing abnormalities associated with favorable to intermediate prognosis. Conclusion. The authors’ attempt to compare CLL with SLL with regards to cytogenetic and IgVH mutational status shows no statistically significant difference. |
| doi_str_mv | 10.1177/1066896911406918 |
| format | Article |
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S. ; Powers, Michelle L. E. ; Dung Nguyen, Tu ; Kreisel, Friederike ; Frater, John L. ; Zehnbauer, Barbara A. ; Burack, Richard ; Hassan, Anjum</creator><creatorcontrib>Yeung, Cecilia C. S. ; Powers, Michelle L. E. ; Dung Nguyen, Tu ; Kreisel, Friederike ; Frater, John L. ; Zehnbauer, Barbara A. ; Burack, Richard ; Hassan, Anjum</creatorcontrib><description>Background. Chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) are regarded as the same entity, with SLL restricted to tissue cases featuring no leukemic phase. In this study, the authors evaluate a group of SLL cases for cytogenetic abnormalities and IgVH gene mutational status to illicit differences between CLL and SLL. Design. IgVH gene polymerase chain reaction amplification and subsequent sequencing were preformed on formalin-fixed, paraffin-embedded archival tissue of 44 patients (SLL n = 34 or CLL n = 10). Cytogenetic data, CD38, and ZAP-70 expression were also evaluated for these cases. Results. The data indicate that 9/34 (26%) SLL cases have somatic hypermutation >2%, which is less than the CLL group where 40% were mutated (4/10). Cytogenetic abnormalities were seen in 58% of the SLL cases with many showing abnormalities associated with favorable to intermediate prognosis. Conclusion. The authors’ attempt to compare CLL with SLL with regards to cytogenetic and IgVH mutational status shows no statistically significant difference.</description><identifier>ISSN: 1066-8969</identifier><identifier>EISSN: 1940-2465</identifier><identifier>DOI: 10.1177/1066896911406918</identifier><identifier>PMID: 21536543</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Adult ; Aged ; CD38 antigen ; Chromosome Aberrations ; DNA Mutational Analysis ; Female ; Flow Cytometry ; Genes, Immunoglobulin Heavy Chain - genetics ; Humans ; Immunoglobulin Variable Region - genetics ; Immunophenotyping ; In Situ Hybridization, Fluorescence ; Leukemia, Lymphocytic, Chronic, B-Cell - genetics ; Male ; Middle Aged ; Polymerase Chain Reaction ; Somatic Hypermutation, Immunoglobulin - genetics</subject><ispartof>International journal of surgical pathology, 2011-10, Vol.19 (5), p.563-569</ispartof><rights>SAGE Publications 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c369t-db1ff67f883ad203c29abb6aab54dbc51d396b6f7664fbbd97ecb5deee47bd03</citedby><cites>FETCH-LOGICAL-c369t-db1ff67f883ad203c29abb6aab54dbc51d396b6f7664fbbd97ecb5deee47bd03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/1066896911406918$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/1066896911406918$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>315,781,785,21824,27929,27930,43626,43627</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21536543$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yeung, Cecilia C. S.</creatorcontrib><creatorcontrib>Powers, Michelle L. E.</creatorcontrib><creatorcontrib>Dung Nguyen, Tu</creatorcontrib><creatorcontrib>Kreisel, Friederike</creatorcontrib><creatorcontrib>Frater, John L.</creatorcontrib><creatorcontrib>Zehnbauer, Barbara A.</creatorcontrib><creatorcontrib>Burack, Richard</creatorcontrib><creatorcontrib>Hassan, Anjum</creatorcontrib><title>Relevance of IgVH Gene Somatic Hypermutation and Interphase Cytogenetics in Lymphomatous Presentation of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma</title><title>International journal of surgical pathology</title><addtitle>Int J Surg Pathol</addtitle><description>Background. Chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) are regarded as the same entity, with SLL restricted to tissue cases featuring no leukemic phase. In this study, the authors evaluate a group of SLL cases for cytogenetic abnormalities and IgVH gene mutational status to illicit differences between CLL and SLL. Design. IgVH gene polymerase chain reaction amplification and subsequent sequencing were preformed on formalin-fixed, paraffin-embedded archival tissue of 44 patients (SLL n = 34 or CLL n = 10). Cytogenetic data, CD38, and ZAP-70 expression were also evaluated for these cases. Results. The data indicate that 9/34 (26%) SLL cases have somatic hypermutation >2%, which is less than the CLL group where 40% were mutated (4/10). Cytogenetic abnormalities were seen in 58% of the SLL cases with many showing abnormalities associated with favorable to intermediate prognosis. Conclusion. The authors’ attempt to compare CLL with SLL with regards to cytogenetic and IgVH mutational status shows no statistically significant difference.</description><subject>Adult</subject><subject>Aged</subject><subject>CD38 antigen</subject><subject>Chromosome Aberrations</subject><subject>DNA Mutational Analysis</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Genes, Immunoglobulin Heavy Chain - genetics</subject><subject>Humans</subject><subject>Immunoglobulin Variable Region - genetics</subject><subject>Immunophenotyping</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Leukemia, Lymphocytic, Chronic, B-Cell - genetics</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Polymerase Chain Reaction</subject><subject>Somatic Hypermutation, Immunoglobulin - genetics</subject><issn>1066-8969</issn><issn>1940-2465</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kVuL1DAYhoMo7kHvvZLc6U3dpDm0uZRBdwYGlN1lb0sOX2e6tklNWqH_xp9qhhkXFHZvcuB93geSD6F3lHyitKquKJGyVlJRykle6xfonCpOipJL8TKfc1wc8jN0kdIDIaSUJX2NzkoqmBScnaPfN9DDL-0t4NDize5-ja_BA74Ng546i9fLCHGYp3wJHmvv8MZPEMe9ToBXyxR2mc5gwp3H22UY94dimBP-HiGBPxWze7WPwWfjEbLLwb6F-QcMnb66HXTf_xudXG_Qq1b3Cd6e9kt09_XL3WpdbL9db1aft4VlUk2FM7RtZdXWNdOuJMyWShsjtTaCO2MFdUxJI9tKSt4a41QF1ggHALwyjrBL9OGoHWP4OUOamqFLFvpee8ivaRQRsmKSqkx-fJakXHJBpKhZRskRtTGkFKFtxtgNOi4NJc1hgM3_A8yV9yf7bAZwj4W_E8tAcQSS3kHzEObo87c8LfwDtpmnnQ</recordid><startdate>201110</startdate><enddate>201110</enddate><creator>Yeung, Cecilia C. S.</creator><creator>Powers, Michelle L. E.</creator><creator>Dung Nguyen, Tu</creator><creator>Kreisel, Friederike</creator><creator>Frater, John L.</creator><creator>Zehnbauer, Barbara A.</creator><creator>Burack, Richard</creator><creator>Hassan, Anjum</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>201110</creationdate><title>Relevance of IgVH Gene Somatic Hypermutation and Interphase Cytogenetics in Lymphomatous Presentation of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma</title><author>Yeung, Cecilia C. S. ; Powers, Michelle L. 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S.</creatorcontrib><creatorcontrib>Powers, Michelle L. E.</creatorcontrib><creatorcontrib>Dung Nguyen, Tu</creatorcontrib><creatorcontrib>Kreisel, Friederike</creatorcontrib><creatorcontrib>Frater, John L.</creatorcontrib><creatorcontrib>Zehnbauer, Barbara A.</creatorcontrib><creatorcontrib>Burack, Richard</creatorcontrib><creatorcontrib>Hassan, Anjum</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of surgical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yeung, Cecilia C. S.</au><au>Powers, Michelle L. E.</au><au>Dung Nguyen, Tu</au><au>Kreisel, Friederike</au><au>Frater, John L.</au><au>Zehnbauer, Barbara A.</au><au>Burack, Richard</au><au>Hassan, Anjum</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relevance of IgVH Gene Somatic Hypermutation and Interphase Cytogenetics in Lymphomatous Presentation of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma</atitle><jtitle>International journal of surgical pathology</jtitle><addtitle>Int J Surg Pathol</addtitle><date>2011-10</date><risdate>2011</risdate><volume>19</volume><issue>5</issue><spage>563</spage><epage>569</epage><pages>563-569</pages><issn>1066-8969</issn><eissn>1940-2465</eissn><abstract>Background. Chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) are regarded as the same entity, with SLL restricted to tissue cases featuring no leukemic phase. In this study, the authors evaluate a group of SLL cases for cytogenetic abnormalities and IgVH gene mutational status to illicit differences between CLL and SLL. Design. IgVH gene polymerase chain reaction amplification and subsequent sequencing were preformed on formalin-fixed, paraffin-embedded archival tissue of 44 patients (SLL n = 34 or CLL n = 10). Cytogenetic data, CD38, and ZAP-70 expression were also evaluated for these cases. Results. The data indicate that 9/34 (26%) SLL cases have somatic hypermutation >2%, which is less than the CLL group where 40% were mutated (4/10). Cytogenetic abnormalities were seen in 58% of the SLL cases with many showing abnormalities associated with favorable to intermediate prognosis. Conclusion. The authors’ attempt to compare CLL with SLL with regards to cytogenetic and IgVH mutational status shows no statistically significant difference.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>21536543</pmid><doi>10.1177/1066896911406918</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Aged CD38 antigen Chromosome Aberrations DNA Mutational Analysis Female Flow Cytometry Genes, Immunoglobulin Heavy Chain - genetics Humans Immunoglobulin Variable Region - genetics Immunophenotyping In Situ Hybridization, Fluorescence Leukemia, Lymphocytic, Chronic, B-Cell - genetics Male Middle Aged Polymerase Chain Reaction Somatic Hypermutation, Immunoglobulin - genetics |
| title | Relevance of IgVH Gene Somatic Hypermutation and Interphase Cytogenetics in Lymphomatous Presentation of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma |
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