The Effect of Pimobendan on Left Atrial Pressure in Dogs with Mitral Valve Regurgitation
Background The effects of pimobendan on left atrial pressure (LAP) in dogs with mitral valve disease (MR) have not been documented in a quantitative manner. Objective The objective was to document and study the short‐term effects of pimobendan on LAP and echocardiographic parameters in MR dogs. Anim...
Gespeichert in:
| Veröffentlicht in: | Journal of veterinary internal medicine 2011-11, Vol.25 (6), p.1328-1333 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1333 |
|---|---|
| container_issue | 6 |
| container_start_page | 1328 |
| container_title | Journal of veterinary internal medicine |
| container_volume | 25 |
| creator | Suzuki, S. Fukushima, R. Ishikawa, T. Hamabe, L. Aytemiz, D. Huai-Che, H. Nakao, S. Machida, N. Tanaka, R. |
| description | Background
The effects of pimobendan on left atrial pressure (LAP) in dogs with mitral valve disease (MR) have not been documented in a quantitative manner.
Objective
The objective was to document and study the short‐term effects of pimobendan on LAP and echocardiographic parameters in MR dogs.
Animals
Eight healthy Beagle dogs weighing 10.0–14.7 kg (3 males and 5 females; aged 2 years) were used.
Methods
Experimental, cross‐over, and interventional study. Dogs with surgically induced MR received pimobendan at either 0.25 mg/kg or 0.50 mg/kg PO q12h for 7 days and then, after a 7‐day wash‐out period, the other dosage. LAP was measured for 30 minutes at baseline and again on days 1, 2, 4, and 7 of pimobendan administration.
Results
Mean LAP was significantly decreased after the administration of 0.25 mg/kg (15.81 ± 5.44 mmHg to 12.67 ± 5.71 mmHg, P |
| doi_str_mv | 10.1111/j.1939-1676.2011.00800.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_24P</sourceid><recordid>TN_cdi_proquest_miscellaneous_905673448</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>905673448</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4560-e251331021f2d9be38654dc0727b83ec940630992fae766663f8bee6ce2b7fdb3</originalsourceid><addsrcrecordid>eNqNkMFy0zAQhjUMTBvavgKjGyeblWTL9oFDJ5RSJgkl05beNLK9ShUcu0gyTd8ehZSc2cvuzP7fSvMRQhmkLNaHdcoqUSVMFjLlwFgKUAKk21dkcli8JhMoK5ZImcExeev9GoDneV4ckWPOoeKSZxNyf_OA9MIYbAIdDL22m6HGvtU9HXo6QxPoeXBWd_TaofejQ2p7-mlYefpkwwOd2-Di8k53v5EucTW6lQ062KE_JW-M7jyevfQTcvv54mb6JZl9u7yans-SJsslJMhzJgQDzgxvqxpFKfOsbaDgRV0KbKoMpICq4kZjIWMJU9aIskFeF6atxQl5v7_76IZfI_qgNtY32HW6x2H0qoJcFiLLypgs98nGDd47NOrR2Y12z4qB2mlVa7Wzp3b21E6r-qtVbSP67uWRsd5gewD_eYyBj_vAk-3w-b8Pq693V_M4RT7Z89YH3B547X6q-PsiVz8Wl2qZLabfF_dLNRd_AKCZlK8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>905673448</pqid></control><display><type>article</type><title>The Effect of Pimobendan on Left Atrial Pressure in Dogs with Mitral Valve Regurgitation</title><source>Wiley Open Access</source><creator>Suzuki, S. ; Fukushima, R. ; Ishikawa, T. ; Hamabe, L. ; Aytemiz, D. ; Huai-Che, H. ; Nakao, S. ; Machida, N. ; Tanaka, R.</creator><creatorcontrib>Suzuki, S. ; Fukushima, R. ; Ishikawa, T. ; Hamabe, L. ; Aytemiz, D. ; Huai-Che, H. ; Nakao, S. ; Machida, N. ; Tanaka, R.</creatorcontrib><description>Background
The effects of pimobendan on left atrial pressure (LAP) in dogs with mitral valve disease (MR) have not been documented in a quantitative manner.
Objective
The objective was to document and study the short‐term effects of pimobendan on LAP and echocardiographic parameters in MR dogs.
Animals
Eight healthy Beagle dogs weighing 10.0–14.7 kg (3 males and 5 females; aged 2 years) were used.
Methods
Experimental, cross‐over, and interventional study. Dogs with surgically induced MR received pimobendan at either 0.25 mg/kg or 0.50 mg/kg PO q12h for 7 days and then, after a 7‐day wash‐out period, the other dosage. LAP was measured for 30 minutes at baseline and again on days 1, 2, 4, and 7 of pimobendan administration.
Results
Mean LAP was significantly decreased after the administration of 0.25 mg/kg (15.81 ± 5.44 mmHg to 12.67 ± 5.71 mmHg, P < .001) and 0.50 mg/kg (15.76 ± 5.45 mmHg to 10.77 ± 5.23 mmHg, P < .001). Also, the 0.50 mg/kg group led to a significantly lower LAP (P < .01) compared with the 0.25 mg/kg group. Significant reduction was seen for the first time 4 days after the administration of 0.25 mg/kg and a day after the administration of 0.50 mg/kg.
Conclusions and Clinical Importance
Pimobendan decreased LAP in a dose‐dependent manner in dogs with acute MR caused by experimental chordal rupture. This study did not evaluate adverse effects of high‐dose pimobendan, and additional studies in clinical patients are warranted.</description><identifier>ISSN: 0891-6640</identifier><identifier>EISSN: 1939-1676</identifier><identifier>DOI: 10.1111/j.1939-1676.2011.00800.x</identifier><identifier>PMID: 22092624</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Animals ; Atrial Function, Left - drug effects ; Blood Pressure - drug effects ; Cross-Over Studies ; Dogs ; Dose-Response Relationship, Drug ; Echocardiography, Three-Dimensional ; Female ; High-dose ; Inodilator ; Male ; Mitral Valve Insufficiency - drug therapy ; Mitral Valve Insufficiency - veterinary ; Pyridazines - administration & dosage ; Pyridazines - therapeutic use ; Radiotelemetry ; Telemetry - veterinary ; Vasodilator Agents - administration & dosage ; Vasodilator Agents - therapeutic use</subject><ispartof>Journal of veterinary internal medicine, 2011-11, Vol.25 (6), p.1328-1333</ispartof><rights>Copyright © 2011 by the American College of Veterinary Internal Medicine</rights><rights>Copyright © 2011 by the American College of Veterinary Internal Medicine.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4560-e251331021f2d9be38654dc0727b83ec940630992fae766663f8bee6ce2b7fdb3</citedby><cites>FETCH-LOGICAL-c4560-e251331021f2d9be38654dc0727b83ec940630992fae766663f8bee6ce2b7fdb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1939-1676.2011.00800.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1939-1676.2011.00800.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,11562,27924,27925,45574,45575,46052,46476</link.rule.ids><linktorsrc>$$Uhttps://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1939-1676.2011.00800.x$$EView_record_in_Wiley-Blackwell$$FView_record_in_$$GWiley-Blackwell</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22092624$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Suzuki, S.</creatorcontrib><creatorcontrib>Fukushima, R.</creatorcontrib><creatorcontrib>Ishikawa, T.</creatorcontrib><creatorcontrib>Hamabe, L.</creatorcontrib><creatorcontrib>Aytemiz, D.</creatorcontrib><creatorcontrib>Huai-Che, H.</creatorcontrib><creatorcontrib>Nakao, S.</creatorcontrib><creatorcontrib>Machida, N.</creatorcontrib><creatorcontrib>Tanaka, R.</creatorcontrib><title>The Effect of Pimobendan on Left Atrial Pressure in Dogs with Mitral Valve Regurgitation</title><title>Journal of veterinary internal medicine</title><addtitle>J Vet Intern Med</addtitle><description>Background
The effects of pimobendan on left atrial pressure (LAP) in dogs with mitral valve disease (MR) have not been documented in a quantitative manner.
Objective
The objective was to document and study the short‐term effects of pimobendan on LAP and echocardiographic parameters in MR dogs.
Animals
Eight healthy Beagle dogs weighing 10.0–14.7 kg (3 males and 5 females; aged 2 years) were used.
Methods
Experimental, cross‐over, and interventional study. Dogs with surgically induced MR received pimobendan at either 0.25 mg/kg or 0.50 mg/kg PO q12h for 7 days and then, after a 7‐day wash‐out period, the other dosage. LAP was measured for 30 minutes at baseline and again on days 1, 2, 4, and 7 of pimobendan administration.
Results
Mean LAP was significantly decreased after the administration of 0.25 mg/kg (15.81 ± 5.44 mmHg to 12.67 ± 5.71 mmHg, P < .001) and 0.50 mg/kg (15.76 ± 5.45 mmHg to 10.77 ± 5.23 mmHg, P < .001). Also, the 0.50 mg/kg group led to a significantly lower LAP (P < .01) compared with the 0.25 mg/kg group. Significant reduction was seen for the first time 4 days after the administration of 0.25 mg/kg and a day after the administration of 0.50 mg/kg.
Conclusions and Clinical Importance
Pimobendan decreased LAP in a dose‐dependent manner in dogs with acute MR caused by experimental chordal rupture. This study did not evaluate adverse effects of high‐dose pimobendan, and additional studies in clinical patients are warranted.</description><subject>Animals</subject><subject>Atrial Function, Left - drug effects</subject><subject>Blood Pressure - drug effects</subject><subject>Cross-Over Studies</subject><subject>Dogs</subject><subject>Dose-Response Relationship, Drug</subject><subject>Echocardiography, Three-Dimensional</subject><subject>Female</subject><subject>High-dose</subject><subject>Inodilator</subject><subject>Male</subject><subject>Mitral Valve Insufficiency - drug therapy</subject><subject>Mitral Valve Insufficiency - veterinary</subject><subject>Pyridazines - administration & dosage</subject><subject>Pyridazines - therapeutic use</subject><subject>Radiotelemetry</subject><subject>Telemetry - veterinary</subject><subject>Vasodilator Agents - administration & dosage</subject><subject>Vasodilator Agents - therapeutic use</subject><issn>0891-6640</issn><issn>1939-1676</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMFy0zAQhjUMTBvavgKjGyeblWTL9oFDJ5RSJgkl05beNLK9ShUcu0gyTd8ehZSc2cvuzP7fSvMRQhmkLNaHdcoqUSVMFjLlwFgKUAKk21dkcli8JhMoK5ZImcExeev9GoDneV4ckWPOoeKSZxNyf_OA9MIYbAIdDL22m6HGvtU9HXo6QxPoeXBWd_TaofejQ2p7-mlYefpkwwOd2-Di8k53v5EucTW6lQ062KE_JW-M7jyevfQTcvv54mb6JZl9u7yans-SJsslJMhzJgQDzgxvqxpFKfOsbaDgRV0KbKoMpICq4kZjIWMJU9aIskFeF6atxQl5v7_76IZfI_qgNtY32HW6x2H0qoJcFiLLypgs98nGDd47NOrR2Y12z4qB2mlVa7Wzp3b21E6r-qtVbSP67uWRsd5gewD_eYyBj_vAk-3w-b8Pq693V_M4RT7Z89YH3B547X6q-PsiVz8Wl2qZLabfF_dLNRd_AKCZlK8</recordid><startdate>201111</startdate><enddate>201111</enddate><creator>Suzuki, S.</creator><creator>Fukushima, R.</creator><creator>Ishikawa, T.</creator><creator>Hamabe, L.</creator><creator>Aytemiz, D.</creator><creator>Huai-Che, H.</creator><creator>Nakao, S.</creator><creator>Machida, N.</creator><creator>Tanaka, R.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201111</creationdate><title>The Effect of Pimobendan on Left Atrial Pressure in Dogs with Mitral Valve Regurgitation</title><author>Suzuki, S. ; Fukushima, R. ; Ishikawa, T. ; Hamabe, L. ; Aytemiz, D. ; Huai-Che, H. ; Nakao, S. ; Machida, N. ; Tanaka, R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4560-e251331021f2d9be38654dc0727b83ec940630992fae766663f8bee6ce2b7fdb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Atrial Function, Left - drug effects</topic><topic>Blood Pressure - drug effects</topic><topic>Cross-Over Studies</topic><topic>Dogs</topic><topic>Dose-Response Relationship, Drug</topic><topic>Echocardiography, Three-Dimensional</topic><topic>Female</topic><topic>High-dose</topic><topic>Inodilator</topic><topic>Male</topic><topic>Mitral Valve Insufficiency - drug therapy</topic><topic>Mitral Valve Insufficiency - veterinary</topic><topic>Pyridazines - administration & dosage</topic><topic>Pyridazines - therapeutic use</topic><topic>Radiotelemetry</topic><topic>Telemetry - veterinary</topic><topic>Vasodilator Agents - administration & dosage</topic><topic>Vasodilator Agents - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Suzuki, S.</creatorcontrib><creatorcontrib>Fukushima, R.</creatorcontrib><creatorcontrib>Ishikawa, T.</creatorcontrib><creatorcontrib>Hamabe, L.</creatorcontrib><creatorcontrib>Aytemiz, D.</creatorcontrib><creatorcontrib>Huai-Che, H.</creatorcontrib><creatorcontrib>Nakao, S.</creatorcontrib><creatorcontrib>Machida, N.</creatorcontrib><creatorcontrib>Tanaka, R.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of veterinary internal medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Suzuki, S.</au><au>Fukushima, R.</au><au>Ishikawa, T.</au><au>Hamabe, L.</au><au>Aytemiz, D.</au><au>Huai-Che, H.</au><au>Nakao, S.</au><au>Machida, N.</au><au>Tanaka, R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effect of Pimobendan on Left Atrial Pressure in Dogs with Mitral Valve Regurgitation</atitle><jtitle>Journal of veterinary internal medicine</jtitle><addtitle>J Vet Intern Med</addtitle><date>2011-11</date><risdate>2011</risdate><volume>25</volume><issue>6</issue><spage>1328</spage><epage>1333</epage><pages>1328-1333</pages><issn>0891-6640</issn><eissn>1939-1676</eissn><abstract>Background
The effects of pimobendan on left atrial pressure (LAP) in dogs with mitral valve disease (MR) have not been documented in a quantitative manner.
Objective
The objective was to document and study the short‐term effects of pimobendan on LAP and echocardiographic parameters in MR dogs.
Animals
Eight healthy Beagle dogs weighing 10.0–14.7 kg (3 males and 5 females; aged 2 years) were used.
Methods
Experimental, cross‐over, and interventional study. Dogs with surgically induced MR received pimobendan at either 0.25 mg/kg or 0.50 mg/kg PO q12h for 7 days and then, after a 7‐day wash‐out period, the other dosage. LAP was measured for 30 minutes at baseline and again on days 1, 2, 4, and 7 of pimobendan administration.
Results
Mean LAP was significantly decreased after the administration of 0.25 mg/kg (15.81 ± 5.44 mmHg to 12.67 ± 5.71 mmHg, P < .001) and 0.50 mg/kg (15.76 ± 5.45 mmHg to 10.77 ± 5.23 mmHg, P < .001). Also, the 0.50 mg/kg group led to a significantly lower LAP (P < .01) compared with the 0.25 mg/kg group. Significant reduction was seen for the first time 4 days after the administration of 0.25 mg/kg and a day after the administration of 0.50 mg/kg.
Conclusions and Clinical Importance
Pimobendan decreased LAP in a dose‐dependent manner in dogs with acute MR caused by experimental chordal rupture. This study did not evaluate adverse effects of high‐dose pimobendan, and additional studies in clinical patients are warranted.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>22092624</pmid><doi>10.1111/j.1939-1676.2011.00800.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | ISSN: 0891-6640 |
| ispartof | Journal of veterinary internal medicine, 2011-11, Vol.25 (6), p.1328-1333 |
| issn | 0891-6640 1939-1676 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_905673448 |
| source | Wiley Open Access |
| subjects | Animals Atrial Function, Left - drug effects Blood Pressure - drug effects Cross-Over Studies Dogs Dose-Response Relationship, Drug Echocardiography, Three-Dimensional Female High-dose Inodilator Male Mitral Valve Insufficiency - drug therapy Mitral Valve Insufficiency - veterinary Pyridazines - administration & dosage Pyridazines - therapeutic use Radiotelemetry Telemetry - veterinary Vasodilator Agents - administration & dosage Vasodilator Agents - therapeutic use |
| title | The Effect of Pimobendan on Left Atrial Pressure in Dogs with Mitral Valve Regurgitation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T08%3A46%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_24P&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Effect%20of%20Pimobendan%20on%20Left%20Atrial%20Pressure%20in%20Dogs%20with%20Mitral%20Valve%20Regurgitation&rft.jtitle=Journal%20of%20veterinary%20internal%20medicine&rft.au=Suzuki,%20S.&rft.date=2011-11&rft.volume=25&rft.issue=6&rft.spage=1328&rft.epage=1333&rft.pages=1328-1333&rft.issn=0891-6640&rft.eissn=1939-1676&rft_id=info:doi/10.1111/j.1939-1676.2011.00800.x&rft_dat=%3Cproquest_24P%3E905673448%3C/proquest_24P%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=905673448&rft_id=info:pmid/22092624&rfr_iscdi=true |