Atorvastatin treatment reduces exercise capacities in rats: involvement of mitochondrial impairments and oxidative stress

Physical exercise exacerbates the cytotoxic effects of statins in skeletal muscle. Mitochondrial impairments may play an important role in the development of muscular symptoms following statin treatment. Our objective was to characterize mitochondrial function and reactive oxygen species (ROS) produ...

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Veröffentlicht in:	Journal of applied physiology (1985) 2011-11, Vol.111 (5), p.1477-1483
Hauptverfasser:	BOUITBIR, Jamal, CHARLES, Anne-Laure, RASSENEUR, Laurence, DUFOUR, Stéphane, PIQUARD, François, GENY, Bernard, ZOLL, Joffrey
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atorvastatin Calcium Biological and medical sciences Cell Respiration - drug effects Cholesterol - blood Creatine Kinase - blood Exercise Fundamental and applied biological sciences. Psychology Glucose Transporter Type 4 - genetics Glucose Transporter Type 4 - metabolism Glycogen - metabolism Heptanoic Acids - pharmacology Male Mitochondria Mitochondria - drug effects Mitochondria - physiology Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Oxidative stress Oxidative Stress - drug effects Oxidative Stress - physiology Physical Conditioning, Animal - physiology Physical Endurance - drug effects Physiology Pyrroles - pharmacology Rats Rats, Wistar Reactive Oxygen Species - metabolism RNA, Messenger - biosynthesis RNA, Messenger - genetics Rodents Statins
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