Statin therapy reduces growth of abdominal aortic aneurysms
The aim of this study was to evaluate the influence of statins on the growth of small abdominal aortic aneurysms (AAAs). We retrospectively examined AAA diameter in 211 patients who had undergone serial imaging surveillance. Patients treated with and without statins were similar regarding age, initi...
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| Veröffentlicht in: | Journal of investigative medicine 2011-12, Vol.59 (8), p.1239-1243 |
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| container_title | Journal of investigative medicine |
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| creator | Karrowni, Wassef Dughman, Saadeddine Hajj, Georges P Miller, Jr, Francis J |
| description | The aim of this study was to evaluate the influence of statins on the growth of small abdominal aortic aneurysms (AAAs).
We retrospectively examined AAA diameter in 211 patients who had undergone serial imaging surveillance.
Patients treated with and without statins were similar regarding age, initial aneurysm size, diagnosis of diabetes and hypertension, and smoking history. Patients receiving statins had a decreased aneurysm growth rate compared with those patients not receiving statins (0.9 mm/y [interquartile range, -1.0 to +1.0] vs 3.2 mm/y [interquartile range, 2.0-4.9], P < 0.0001). This difference in the rate of growth was maintained after adjusting for potential confounding factors.
To date, this is the one of the largest retrospective studies demonstrating an association between statin use and decreased growth rate of AAA. |
| doi_str_mv | 10.2130/JIM.0b013e31823548e8 |
| format | Article |
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We retrospectively examined AAA diameter in 211 patients who had undergone serial imaging surveillance.
Patients treated with and without statins were similar regarding age, initial aneurysm size, diagnosis of diabetes and hypertension, and smoking history. Patients receiving statins had a decreased aneurysm growth rate compared with those patients not receiving statins (0.9 mm/y [interquartile range, -1.0 to +1.0] vs 3.2 mm/y [interquartile range, 2.0-4.9], P < 0.0001). This difference in the rate of growth was maintained after adjusting for potential confounding factors.
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We retrospectively examined AAA diameter in 211 patients who had undergone serial imaging surveillance.
Patients treated with and without statins were similar regarding age, initial aneurysm size, diagnosis of diabetes and hypertension, and smoking history. Patients receiving statins had a decreased aneurysm growth rate compared with those patients not receiving statins (0.9 mm/y [interquartile range, -1.0 to +1.0] vs 3.2 mm/y [interquartile range, 2.0-4.9], P < 0.0001). This difference in the rate of growth was maintained after adjusting for potential confounding factors.
To date, this is the one of the largest retrospective studies demonstrating an association between statin use and decreased growth rate of AAA.</description><subject>Aged</subject><subject>Aortic Aneurysm, Abdominal - drug therapy</subject><subject>Aortic Aneurysm, Abdominal - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use</subject><subject>Linear Models</subject><subject>Male</subject><subject>Multivariate Analysis</subject><issn>1708-8267</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1j0tLxDAUhYMgzjj6D0Syc9Ux96bNA1cyODoy4kJdlzRJnUpfJi3Sf2_BcXPO5uM8CLkCtkbg7PZ597JmBQPuOSjkWaq8OiFLkEwlCoVckPMYvxhDkWk8IwsErSUHWJK7t8EMVUuHgw-mn2jwbrQ-0s_Q_QwH2pXUFK5rqtbU1HRhqCw1rR_DFJt4QU5LU0d_efQV-dg-vG-ekv3r425zv08sMAGJKFPtHTowFlAra0UqlZSoMmdFWZQqxVmYAeGVRJz7OIqisCk6Zpx2fEVu_nL70H2PPg55U0Xr63pe0o0x1ywTcn6kZ_L6SI5F413eh6oxYcr___Jf2P9XOg</recordid><startdate>201112</startdate><enddate>201112</enddate><creator>Karrowni, Wassef</creator><creator>Dughman, Saadeddine</creator><creator>Hajj, Georges P</creator><creator>Miller, Jr, Francis J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201112</creationdate><title>Statin therapy reduces growth of abdominal aortic aneurysms</title><author>Karrowni, Wassef ; Dughman, Saadeddine ; Hajj, Georges P ; Miller, Jr, Francis J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1061-6f49ed2d1ac1298cc647877285dc6fbf842bf80a16e8722abd326bbc42d0ad9d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aged</topic><topic>Aortic Aneurysm, Abdominal - drug therapy</topic><topic>Aortic Aneurysm, Abdominal - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use</topic><topic>Linear Models</topic><topic>Male</topic><topic>Multivariate Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Karrowni, Wassef</creatorcontrib><creatorcontrib>Dughman, Saadeddine</creatorcontrib><creatorcontrib>Hajj, Georges P</creatorcontrib><creatorcontrib>Miller, Jr, Francis J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of investigative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karrowni, Wassef</au><au>Dughman, Saadeddine</au><au>Hajj, Georges P</au><au>Miller, Jr, Francis J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Statin therapy reduces growth of abdominal aortic aneurysms</atitle><jtitle>Journal of investigative medicine</jtitle><addtitle>J Investig Med</addtitle><date>2011-12</date><risdate>2011</risdate><volume>59</volume><issue>8</issue><spage>1239</spage><epage>1243</epage><pages>1239-1243</pages><eissn>1708-8267</eissn><abstract>The aim of this study was to evaluate the influence of statins on the growth of small abdominal aortic aneurysms (AAAs).
We retrospectively examined AAA diameter in 211 patients who had undergone serial imaging surveillance.
Patients treated with and without statins were similar regarding age, initial aneurysm size, diagnosis of diabetes and hypertension, and smoking history. Patients receiving statins had a decreased aneurysm growth rate compared with those patients not receiving statins (0.9 mm/y [interquartile range, -1.0 to +1.0] vs 3.2 mm/y [interquartile range, 2.0-4.9], P < 0.0001). This difference in the rate of growth was maintained after adjusting for potential confounding factors.
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| fulltext | fulltext |
| identifier | EISSN: 1708-8267 |
| ispartof | Journal of investigative medicine, 2011-12, Vol.59 (8), p.1239-1243 |
| issn | 1708-8267 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_905671999 |
| source | MEDLINE; SAGE Complete |
| subjects | Aged Aortic Aneurysm, Abdominal - drug therapy Aortic Aneurysm, Abdominal - pathology Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Linear Models Male Multivariate Analysis |
| title | Statin therapy reduces growth of abdominal aortic aneurysms |
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