Prevention of free fatty acid-induced hepatic lipotoxicity by carnitine via reversal of mitochondrial dysfunction

Background: Mitochondria are the main sites for fatty acid oxidation and play a central role in lipotoxicity and nonalcoholic steatohepatitis. Aims: We investigated whether carnitine prevents free fatty acid (FFA)‐induced lipotoxicity in vitro and in vivo. Methods: HepG2 cells were incubated with FF...

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Veröffentlicht in:	Liver international 2011-10, Vol.31 (9), p.1315-1324
Hauptverfasser:	Jun, Dae Won, Cho, Won Kyeong, Jun, Jin Hyun, Kwon, Hyuk Jin, Jang, Ki-Seok, Kim, Hyun-Jeong, Jeon, Hye Jun, Lee, Kang Nyeong, Lee, Hang Lak, Lee, Oh Young, Yoon, Byung Chul, Choi, Ho Soon, Hahm, Joon Soo, Lee, Min Ho
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Animals Apoptosis - drug effects carnitine Carnitine - analogs & derivatives Carnitine - pharmacology Carnitine O-Palmitoyltransferase - genetics Carnitine O-Palmitoyltransferase - metabolism Choline Deficiency - complications Disease Models, Animal DNA, Mitochondrial - metabolism Fatty Acids, Nonesterified - metabolism Fatty Liver - etiology Fatty Liver - genetics Fatty Liver - metabolism Fatty Liver - pathology Fatty Liver - prevention & control Gene Expression Regulation - drug effects Hep G2 Cells Humans lipotoxicity Liver - drug effects Liver - metabolism Liver - pathology Lysosomes - drug effects Lysosomes - metabolism Membrane Potential, Mitochondrial - drug effects Methionine - deficiency mitochondria Mitochondria, Liver - drug effects Mitochondria, Liver - metabolism Mitochondria, Liver - pathology Non-alcoholic Fatty Liver Disease Oxidation-Reduction Oxidative Stress - drug effects PPAR gamma - genetics PPAR gamma - metabolism Rats Rats, Inbred OLETF Rats, Long-Evans RNA, Messenger - metabolism Thioctic Acid - analogs & derivatives Thioctic Acid - pharmacology Time Factors
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