Treatment with Adenosine Diphosphate Receptor Inhibitors—Longitudinal Assessment of Treatment Patterns and Events after Acute Coronary Syndrome (TRANSLATE-ACS) study design: Expanding the paradigm of longitudinal observational research
Background Platelet inhibition is critical in reducing both short- and long-term atherothrombotic risks after acute myocardial infarction (MI), especially among patients managed with percutaneous coronary intervention (PCI). Currently available antiplatelet medications, including adenosine diphospha...
Gespeichert in:
| Veröffentlicht in: | The American heart journal 2011-11, Vol.162 (5), p.844-851 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 851 |
|---|---|
| container_issue | 5 |
| container_start_page | 844 |
| container_title | The American heart journal |
| container_volume | 162 |
| creator | Chin, Chee Tang, MBChB, MRCP Wang, Tracy Y., MD, MHS, MSc Anstrom, Kevin J., PhD Zhu, Baojin, PhD Maa, Jen-Fue, PhD Messenger, John C., MD Ryan, Kelley A., BA Davidson-Ray, Linda Zettler, Marjorie, PhD, MPH Effron, Mark B., MD Mark, Daniel B., MD Peterson, Eric D., MD, MPH |
| description | Background Platelet inhibition is critical in reducing both short- and long-term atherothrombotic risks after acute myocardial infarction (MI), especially among patients managed with percutaneous coronary intervention (PCI). Currently available antiplatelet medications, including adenosine diphosphate (ADP) receptor inhibitors, have demonstrated variability in efficacy and safety in clinical trials, yet few studies have examined contemporary “real-world” approaches to platelet inhibition and associated outcomes. Methods TRANSLATE-ACS is a prospective observational study that will track up to 17,000 MI patients managed with PCI, from the inhospital to outpatient settings for up to 12 months postdischarge to provide a comprehensive picture of current treatment patterns and outcomes in routine clinical practice. TRANSLATE-ACS exemplifies a collaborative study design that efficiently builds upon a well-established PCI registry platform, and yet, through a systematic telephone interview follow-up process, provides important longitudinal clinical and economic follow-up capacity through 15 months after initial MI hospitalization. Furthermore, TRANSLATE-ACS incorporates a hospital-level, clustered, randomized substudy to investigate the impact of point-of-care platelet inhibition testing on subsequent patient management. Finally, TRANSLATE-ACS provides feedback through quarterly reports to participating sites on their care practices benchmarked to peer performance to support and promote longitudinal quality of cardiovascular care delivery. Conclusion TRANSLATE-ACS not only addresses important clinical and scientific questions but also includes pioneering design features that will assist in the evolution of clinical registries. |
| doi_str_mv | 10.1016/j.ahj.2011.08.021 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_905669535</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0002870311006405</els_id><sourcerecordid>3272409631</sourcerecordid><originalsourceid>FETCH-LOGICAL-c465t-8e8e9d7226cda182b0cfb3231ea4a9817e731d5f1b450d362ee362f73221812b3</originalsourceid><addsrcrecordid>eNp9Uk2P0zAQjRCIXRZ-ABdkCSHg0GI73yAhRaXAShWgbTlbjj1pXFI7eNKF3vgR_ELu_AcctlC0By72zOjNe-Pxi6L7jE4ZZdmzzVS2mymnjE1pMaWc3YhOGS3zSZYnyc3olFLKJ0VO45PoDuImpBkvstvRCee0jDmlp9HPlQc5bMEO5IsZWlJpsA6NBfLK9K3DvpUDkAtQ0A_Ok3PbmtqECH98-75wdm2GnTZWdqRCBMTfRK4hR9YPchjAWyTSajK_DKUQNqFEKrUL1DPnnZV-T5Z7q73bAnmyuqjeLRfVaj6pZsunBIPEnmhAs7bPyfxrH5iMXZOhBdJLL7VZb0fN7t9xXI3gL-Vg3Jh5QJBetXejW43sEO4d7rPo4-v5avZ2snj_5nxWLSYqydJhUkABpc45z5SWrOA1VU0d85iBTGRZsBzymOm0YXWSUh1nHCAcTR5zzgrG6_gsenzF23v3eQc4iK1BBV0nLbgdipKmWVamcRqQD68hN27nw8woWMqSIi2zsggodoVS3iF6aETvzTZsTTAqRiuIjQhWEKMVBC1EsELoeXBg3tVb0H87_vx9ADw6ACQq2TVeWmXwiEt5yigfxV9c4SBs7NKAF6gMWAXaeFCD0M78d4yX17pVZ6wJgp9gD3h8rUAuqFiOnh0ty1hwa0LT-BcBN-sK</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1514859698</pqid></control><display><type>article</type><title>Treatment with Adenosine Diphosphate Receptor Inhibitors—Longitudinal Assessment of Treatment Patterns and Events after Acute Coronary Syndrome (TRANSLATE-ACS) study design: Expanding the paradigm of longitudinal observational research</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Chin, Chee Tang, MBChB, MRCP ; Wang, Tracy Y., MD, MHS, MSc ; Anstrom, Kevin J., PhD ; Zhu, Baojin, PhD ; Maa, Jen-Fue, PhD ; Messenger, John C., MD ; Ryan, Kelley A., BA ; Davidson-Ray, Linda ; Zettler, Marjorie, PhD, MPH ; Effron, Mark B., MD ; Mark, Daniel B., MD ; Peterson, Eric D., MD, MPH</creator><creatorcontrib>Chin, Chee Tang, MBChB, MRCP ; Wang, Tracy Y., MD, MHS, MSc ; Anstrom, Kevin J., PhD ; Zhu, Baojin, PhD ; Maa, Jen-Fue, PhD ; Messenger, John C., MD ; Ryan, Kelley A., BA ; Davidson-Ray, Linda ; Zettler, Marjorie, PhD, MPH ; Effron, Mark B., MD ; Mark, Daniel B., MD ; Peterson, Eric D., MD, MPH</creatorcontrib><description>Background Platelet inhibition is critical in reducing both short- and long-term atherothrombotic risks after acute myocardial infarction (MI), especially among patients managed with percutaneous coronary intervention (PCI). Currently available antiplatelet medications, including adenosine diphosphate (ADP) receptor inhibitors, have demonstrated variability in efficacy and safety in clinical trials, yet few studies have examined contemporary “real-world” approaches to platelet inhibition and associated outcomes. Methods TRANSLATE-ACS is a prospective observational study that will track up to 17,000 MI patients managed with PCI, from the inhospital to outpatient settings for up to 12 months postdischarge to provide a comprehensive picture of current treatment patterns and outcomes in routine clinical practice. TRANSLATE-ACS exemplifies a collaborative study design that efficiently builds upon a well-established PCI registry platform, and yet, through a systematic telephone interview follow-up process, provides important longitudinal clinical and economic follow-up capacity through 15 months after initial MI hospitalization. Furthermore, TRANSLATE-ACS incorporates a hospital-level, clustered, randomized substudy to investigate the impact of point-of-care platelet inhibition testing on subsequent patient management. Finally, TRANSLATE-ACS provides feedback through quarterly reports to participating sites on their care practices benchmarked to peer performance to support and promote longitudinal quality of cardiovascular care delivery. Conclusion TRANSLATE-ACS not only addresses important clinical and scientific questions but also includes pioneering design features that will assist in the evolution of clinical registries.</description><identifier>ISSN: 0002-8703</identifier><identifier>EISSN: 1097-6744</identifier><identifier>DOI: 10.1016/j.ahj.2011.08.021</identifier><identifier>PMID: 22093200</identifier><identifier>CODEN: AHJOA2</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Acute Coronary Syndrome - drug therapy ; Acute coronary syndromes ; Adenosine ; Biological and medical sciences ; Cardiology. Vascular system ; Cardiovascular ; Clinical medicine ; Coronary heart disease ; Drug therapy ; Heart ; Heart attacks ; Hospitalization ; Humans ; Longitudinal Studies ; Medical sciences ; Myocarditis. Cardiomyopathies ; Patient Selection ; Platelet Aggregation Inhibitors - administration & dosage ; Purinergic P2Y Receptor Antagonists - administration & dosage ; Randomized Controlled Trials as Topic ; Registries ; Research Design ; Stroke ; Thrombosis</subject><ispartof>The American heart journal, 2011-11, Vol.162 (5), p.844-851</ispartof><rights>Mosby, Inc.</rights><rights>2011 Mosby, Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Mosby, Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Nov 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-8e8e9d7226cda182b0cfb3231ea4a9817e731d5f1b450d362ee362f73221812b3</citedby><cites>FETCH-LOGICAL-c465t-8e8e9d7226cda182b0cfb3231ea4a9817e731d5f1b450d362ee362f73221812b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002870311006405$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25251028$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22093200$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chin, Chee Tang, MBChB, MRCP</creatorcontrib><creatorcontrib>Wang, Tracy Y., MD, MHS, MSc</creatorcontrib><creatorcontrib>Anstrom, Kevin J., PhD</creatorcontrib><creatorcontrib>Zhu, Baojin, PhD</creatorcontrib><creatorcontrib>Maa, Jen-Fue, PhD</creatorcontrib><creatorcontrib>Messenger, John C., MD</creatorcontrib><creatorcontrib>Ryan, Kelley A., BA</creatorcontrib><creatorcontrib>Davidson-Ray, Linda</creatorcontrib><creatorcontrib>Zettler, Marjorie, PhD, MPH</creatorcontrib><creatorcontrib>Effron, Mark B., MD</creatorcontrib><creatorcontrib>Mark, Daniel B., MD</creatorcontrib><creatorcontrib>Peterson, Eric D., MD, MPH</creatorcontrib><title>Treatment with Adenosine Diphosphate Receptor Inhibitors—Longitudinal Assessment of Treatment Patterns and Events after Acute Coronary Syndrome (TRANSLATE-ACS) study design: Expanding the paradigm of longitudinal observational research</title><title>The American heart journal</title><addtitle>Am Heart J</addtitle><description>Background Platelet inhibition is critical in reducing both short- and long-term atherothrombotic risks after acute myocardial infarction (MI), especially among patients managed with percutaneous coronary intervention (PCI). Currently available antiplatelet medications, including adenosine diphosphate (ADP) receptor inhibitors, have demonstrated variability in efficacy and safety in clinical trials, yet few studies have examined contemporary “real-world” approaches to platelet inhibition and associated outcomes. Methods TRANSLATE-ACS is a prospective observational study that will track up to 17,000 MI patients managed with PCI, from the inhospital to outpatient settings for up to 12 months postdischarge to provide a comprehensive picture of current treatment patterns and outcomes in routine clinical practice. TRANSLATE-ACS exemplifies a collaborative study design that efficiently builds upon a well-established PCI registry platform, and yet, through a systematic telephone interview follow-up process, provides important longitudinal clinical and economic follow-up capacity through 15 months after initial MI hospitalization. Furthermore, TRANSLATE-ACS incorporates a hospital-level, clustered, randomized substudy to investigate the impact of point-of-care platelet inhibition testing on subsequent patient management. Finally, TRANSLATE-ACS provides feedback through quarterly reports to participating sites on their care practices benchmarked to peer performance to support and promote longitudinal quality of cardiovascular care delivery. Conclusion TRANSLATE-ACS not only addresses important clinical and scientific questions but also includes pioneering design features that will assist in the evolution of clinical registries.</description><subject>Acute Coronary Syndrome - drug therapy</subject><subject>Acute coronary syndromes</subject><subject>Adenosine</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular</subject><subject>Clinical medicine</subject><subject>Coronary heart disease</subject><subject>Drug therapy</subject><subject>Heart</subject><subject>Heart attacks</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Medical sciences</subject><subject>Myocarditis. Cardiomyopathies</subject><subject>Patient Selection</subject><subject>Platelet Aggregation Inhibitors - administration & dosage</subject><subject>Purinergic P2Y Receptor Antagonists - administration & dosage</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Registries</subject><subject>Research Design</subject><subject>Stroke</subject><subject>Thrombosis</subject><issn>0002-8703</issn><issn>1097-6744</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9Uk2P0zAQjRCIXRZ-ABdkCSHg0GI73yAhRaXAShWgbTlbjj1pXFI7eNKF3vgR_ELu_AcctlC0By72zOjNe-Pxi6L7jE4ZZdmzzVS2mymnjE1pMaWc3YhOGS3zSZYnyc3olFLKJ0VO45PoDuImpBkvstvRCee0jDmlp9HPlQc5bMEO5IsZWlJpsA6NBfLK9K3DvpUDkAtQ0A_Ok3PbmtqECH98-75wdm2GnTZWdqRCBMTfRK4hR9YPchjAWyTSajK_DKUQNqFEKrUL1DPnnZV-T5Z7q73bAnmyuqjeLRfVaj6pZsunBIPEnmhAs7bPyfxrH5iMXZOhBdJLL7VZb0fN7t9xXI3gL-Vg3Jh5QJBetXejW43sEO4d7rPo4-v5avZ2snj_5nxWLSYqydJhUkABpc45z5SWrOA1VU0d85iBTGRZsBzymOm0YXWSUh1nHCAcTR5zzgrG6_gsenzF23v3eQc4iK1BBV0nLbgdipKmWVamcRqQD68hN27nw8woWMqSIi2zsggodoVS3iF6aETvzTZsTTAqRiuIjQhWEKMVBC1EsELoeXBg3tVb0H87_vx9ADw6ACQq2TVeWmXwiEt5yigfxV9c4SBs7NKAF6gMWAXaeFCD0M78d4yX17pVZ6wJgp9gD3h8rUAuqFiOnh0ty1hwa0LT-BcBN-sK</recordid><startdate>20111101</startdate><enddate>20111101</enddate><creator>Chin, Chee Tang, MBChB, MRCP</creator><creator>Wang, Tracy Y., MD, MHS, MSc</creator><creator>Anstrom, Kevin J., PhD</creator><creator>Zhu, Baojin, PhD</creator><creator>Maa, Jen-Fue, PhD</creator><creator>Messenger, John C., MD</creator><creator>Ryan, Kelley A., BA</creator><creator>Davidson-Ray, Linda</creator><creator>Zettler, Marjorie, PhD, MPH</creator><creator>Effron, Mark B., MD</creator><creator>Mark, Daniel B., MD</creator><creator>Peterson, Eric D., MD, MPH</creator><general>Elsevier Inc</general><general>Mosby</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20111101</creationdate><title>Treatment with Adenosine Diphosphate Receptor Inhibitors—Longitudinal Assessment of Treatment Patterns and Events after Acute Coronary Syndrome (TRANSLATE-ACS) study design: Expanding the paradigm of longitudinal observational research</title><author>Chin, Chee Tang, MBChB, MRCP ; Wang, Tracy Y., MD, MHS, MSc ; Anstrom, Kevin J., PhD ; Zhu, Baojin, PhD ; Maa, Jen-Fue, PhD ; Messenger, John C., MD ; Ryan, Kelley A., BA ; Davidson-Ray, Linda ; Zettler, Marjorie, PhD, MPH ; Effron, Mark B., MD ; Mark, Daniel B., MD ; Peterson, Eric D., MD, MPH</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-8e8e9d7226cda182b0cfb3231ea4a9817e731d5f1b450d362ee362f73221812b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acute Coronary Syndrome - drug therapy</topic><topic>Acute coronary syndromes</topic><topic>Adenosine</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular</topic><topic>Clinical medicine</topic><topic>Coronary heart disease</topic><topic>Drug therapy</topic><topic>Heart</topic><topic>Heart attacks</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Medical sciences</topic><topic>Myocarditis. Cardiomyopathies</topic><topic>Patient Selection</topic><topic>Platelet Aggregation Inhibitors - administration & dosage</topic><topic>Purinergic P2Y Receptor Antagonists - administration & dosage</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Registries</topic><topic>Research Design</topic><topic>Stroke</topic><topic>Thrombosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chin, Chee Tang, MBChB, MRCP</creatorcontrib><creatorcontrib>Wang, Tracy Y., MD, MHS, MSc</creatorcontrib><creatorcontrib>Anstrom, Kevin J., PhD</creatorcontrib><creatorcontrib>Zhu, Baojin, PhD</creatorcontrib><creatorcontrib>Maa, Jen-Fue, PhD</creatorcontrib><creatorcontrib>Messenger, John C., MD</creatorcontrib><creatorcontrib>Ryan, Kelley A., BA</creatorcontrib><creatorcontrib>Davidson-Ray, Linda</creatorcontrib><creatorcontrib>Zettler, Marjorie, PhD, MPH</creatorcontrib><creatorcontrib>Effron, Mark B., MD</creatorcontrib><creatorcontrib>Mark, Daniel B., MD</creatorcontrib><creatorcontrib>Peterson, Eric D., MD, MPH</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The American heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chin, Chee Tang, MBChB, MRCP</au><au>Wang, Tracy Y., MD, MHS, MSc</au><au>Anstrom, Kevin J., PhD</au><au>Zhu, Baojin, PhD</au><au>Maa, Jen-Fue, PhD</au><au>Messenger, John C., MD</au><au>Ryan, Kelley A., BA</au><au>Davidson-Ray, Linda</au><au>Zettler, Marjorie, PhD, MPH</au><au>Effron, Mark B., MD</au><au>Mark, Daniel B., MD</au><au>Peterson, Eric D., MD, MPH</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment with Adenosine Diphosphate Receptor Inhibitors—Longitudinal Assessment of Treatment Patterns and Events after Acute Coronary Syndrome (TRANSLATE-ACS) study design: Expanding the paradigm of longitudinal observational research</atitle><jtitle>The American heart journal</jtitle><addtitle>Am Heart J</addtitle><date>2011-11-01</date><risdate>2011</risdate><volume>162</volume><issue>5</issue><spage>844</spage><epage>851</epage><pages>844-851</pages><issn>0002-8703</issn><eissn>1097-6744</eissn><coden>AHJOA2</coden><abstract>Background Platelet inhibition is critical in reducing both short- and long-term atherothrombotic risks after acute myocardial infarction (MI), especially among patients managed with percutaneous coronary intervention (PCI). Currently available antiplatelet medications, including adenosine diphosphate (ADP) receptor inhibitors, have demonstrated variability in efficacy and safety in clinical trials, yet few studies have examined contemporary “real-world” approaches to platelet inhibition and associated outcomes. Methods TRANSLATE-ACS is a prospective observational study that will track up to 17,000 MI patients managed with PCI, from the inhospital to outpatient settings for up to 12 months postdischarge to provide a comprehensive picture of current treatment patterns and outcomes in routine clinical practice. TRANSLATE-ACS exemplifies a collaborative study design that efficiently builds upon a well-established PCI registry platform, and yet, through a systematic telephone interview follow-up process, provides important longitudinal clinical and economic follow-up capacity through 15 months after initial MI hospitalization. Furthermore, TRANSLATE-ACS incorporates a hospital-level, clustered, randomized substudy to investigate the impact of point-of-care platelet inhibition testing on subsequent patient management. Finally, TRANSLATE-ACS provides feedback through quarterly reports to participating sites on their care practices benchmarked to peer performance to support and promote longitudinal quality of cardiovascular care delivery. Conclusion TRANSLATE-ACS not only addresses important clinical and scientific questions but also includes pioneering design features that will assist in the evolution of clinical registries.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>22093200</pmid><doi>10.1016/j.ahj.2011.08.021</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-8703 |
| ispartof | The American heart journal, 2011-11, Vol.162 (5), p.844-851 |
| issn | 0002-8703 1097-6744 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_905669535 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acute Coronary Syndrome - drug therapy Acute coronary syndromes Adenosine Biological and medical sciences Cardiology. Vascular system Cardiovascular Clinical medicine Coronary heart disease Drug therapy Heart Heart attacks Hospitalization Humans Longitudinal Studies Medical sciences Myocarditis. Cardiomyopathies Patient Selection Platelet Aggregation Inhibitors - administration & dosage Purinergic P2Y Receptor Antagonists - administration & dosage Randomized Controlled Trials as Topic Registries Research Design Stroke Thrombosis |
| title | Treatment with Adenosine Diphosphate Receptor Inhibitors—Longitudinal Assessment of Treatment Patterns and Events after Acute Coronary Syndrome (TRANSLATE-ACS) study design: Expanding the paradigm of longitudinal observational research |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-13T03%3A49%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Treatment%20with%20Adenosine%20Diphosphate%20Receptor%20Inhibitors%E2%80%94Longitudinal%20Assessment%20of%20Treatment%20Patterns%20and%20Events%20after%20Acute%20Coronary%20Syndrome%20(TRANSLATE-ACS)%20study%20design:%20Expanding%20the%20paradigm%20of%20longitudinal%20observational%20research&rft.jtitle=The%20American%20heart%20journal&rft.au=Chin,%20Chee%20Tang,%20MBChB,%20MRCP&rft.date=2011-11-01&rft.volume=162&rft.issue=5&rft.spage=844&rft.epage=851&rft.pages=844-851&rft.issn=0002-8703&rft.eissn=1097-6744&rft.coden=AHJOA2&rft_id=info:doi/10.1016/j.ahj.2011.08.021&rft_dat=%3Cproquest_cross%3E3272409631%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1514859698&rft_id=info:pmid/22093200&rft_els_id=1_s2_0_S0002870311006405&rfr_iscdi=true |