Fluorinated amino-derivatives of the sesquiterpene lactone, parthenolide, as (19)f NMR probes in deuterium-free environments

The design, synthesis, and biological activity of fluorinated amino-derivatives of the sesquiterpene lactone, parthenolide, are described. A fluorinated aminoparthenolide analogue with biological activity similar to the parent natural product was discovered, and its X-ray structure was obtained. Thi...

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Veröffentlicht in:	Journal of medicinal chemistry 2011-11, Vol.54 (22), p.7934-7941
Hauptverfasser:	Woods, James R, Mo, Huaping, Bieberich, Andrew A, Alavanja, Tanja, Colby, David A
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Cell Line, Tumor Crystallography, X-Ray Deuterium Drug Screening Assays, Antitumor Fluorine Glutathione - chemistry Humans Lactones - chemical synthesis Lactones - chemistry Lactones - pharmacology Magnetic Resonance Spectroscopy - methods Molecular Probes - chemical synthesis Molecular Probes - chemistry Molecular Probes - pharmacology Molecular Structure Sesquiterpenes - chemical synthesis Sesquiterpenes - chemistry Sesquiterpenes - pharmacology Stereoisomerism Structure-Activity Relationship
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