IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens

IL-17RE is an orphan receptor of the IL-17 receptor family. Qian and colleagues identify IL-17RE as the receptor specific for IL-17C signaling in mucosal defense against intestinal pathogens. Interleukin 17 receptor E (IL-17RE) is an orphan receptor of the IL-17 receptor family. Here we show that IL...

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Veröffentlicht in:	Nature immunology 2011-12, Vol.12 (12), p.1151-1158
Hauptverfasser:	Song, Xinyang, Zhu, Shu, Shi, Peiqing, Liu, Yan, Shi, Yufang, Levin, Steven D, Qian, Youcun
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/255/1318 631/250/347 631/250/516 Animals Antimicrobial Cationic Peptides - genetics Antimicrobial Cationic Peptides - immunology Biomedical and Life Sciences Biomedicine Cell Line Citrobacter rodentium Colon - immunology Colon - metabolism Enterobacteriaceae Infections - genetics Enterobacteriaceae Infections - immunology Enterobacteriaceae Infections - microbiology Gene Expression Regulation Health aspects HEK293 Cells HT29 Cells Humans Immunity, Mucosal - genetics Immunity, Mucosal - immunology Immunology Infection Infectious Diseases Interleukin-17 - metabolism Interleukin-22 Interleukins Interleukins - metabolism Intestinal Mucosa - immunology Intestinal Mucosa - microbiology Intestinal Mucosa - pathology Mice Mice, Inbred C57BL Mice, Knockout Mortality Pathogenic microorganisms Pathogens Peptides Physiological aspects Receptors, Interleukin-17 - genetics Receptors, Interleukin-17 - metabolism Signal Transduction
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