Multiple Presentation of Scfv800E6 on Silica Nanospheres Enhances Targeting Efficiency Toward HER-2 Receptor in Breast Cancer Cells

Spherical silica nanoparticles (SNP) have been synthesized and functionalized with anti-HER-2 scFv800E6 antibody by both localized histidine-tag recognition, leading to an oriented protein ligation, and glutaraldehyde cross-linking, exploiting a statistical reactivity of lysine amine groups in the p...

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Veröffentlicht in:	Bioconjugate chemistry 2011-11, Vol.22 (11), p.2296-2303
Hauptverfasser:	Mazzucchelli, Serena, Verderio, Paolo, Sommaruga, Silvia, Colombo, Miriam, Salvadè, Agnese, Corsi, Fabio, Galeffi, Patrizia, Tortora, Paolo, Prosperi, Davide
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Cell Line, Tumor Cells Chemical synthesis Female Humans Mice Models, Molecular Molecular Structure Nanospheres - chemistry Nanospheres - ultrastructure Proteins Receptor, ErbB-2 - metabolism Silica Silicon Dioxide - chemistry Single-Chain Antibodies - chemistry Single-Chain Antibodies - genetics Single-Chain Antibodies - metabolism Single-Chain Antibodies - therapeutic use
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