Regenerative Biomaterials that “Click”: Simple, Aqueous-Based Protocols for Hydrogel Synthesis, Surface Immobilization, and 3D Patterning
The click chemistry era has generated a library of versatile “spring-loaded” reactions that offer high yields, regio- and stereospecificity, and outstanding functional group tolerance. These powerful transformations are particularly advantageous for the design of sophisticated biomaterials that requ...
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| Veröffentlicht in: | Bioconjugate chemistry 2011-11, Vol.22 (11), p.2199-2209 |
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| container_title | Bioconjugate chemistry |
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| creator | Nimmo, Chelsea M Shoichet, Molly S |
| description | The click chemistry era has generated a library of versatile “spring-loaded” reactions that offer high yields, regio- and stereospecificity, and outstanding functional group tolerance. These powerful transformations are particularly advantageous for the design of sophisticated biomaterials that require high levels of precision and control, namely, materials that promote tissue regeneration such as hydrogels, 2D functionalized substrates, and 3D biomimetic scaffolds. In this review, the synthesis and application of regenerative biomaterials via click chemistry are summarized. Particular emphasis is placed on the copper(I)-catalyzed alkyne–azide cycloaddition, Diels–Alder cycloadditions, and thiol–click coupling. |
| doi_str_mv | 10.1021/bc200281k |
| format | Article |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | Alkynes - chemistry Azides - chemistry Biocompatible Materials - chemical synthesis Biocompatible Materials - chemistry Biomaterials Biomedical materials Biomimetics Chemical reactions Chemical synthesis Click Chemistry - methods Copper - chemistry Drug Delivery Systems Humans Hydrogels Hydrogels - chemical synthesis Hydrogels - chemistry Maleimides - chemistry Molecular Structure Regeneration Regenerative Medicine - methods Sulfhydryl Compounds - chemistry Surface Properties Tissue Engineering - methods Water - chemistry |
| title | Regenerative Biomaterials that “Click”: Simple, Aqueous-Based Protocols for Hydrogel Synthesis, Surface Immobilization, and 3D Patterning |
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