Overexpression of GRP78 protects glial cells from endoplasmic reticulum stress

► GRP78 overexpression prior to injury protects C6 glioma cells from ER stress. ► GRP78 expression increases following exposure to high concentrations of glutamate. ► Transient expression of GRP78 protects against tunicamycin and glutamate injury. Endoplasmic reticulum (ER) stress induces apoptotic...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience letters 2011-10, Vol.504 (3), p.271-276
Hauptverfasser:	Suyama, Kaori, Watanabe, Masahiko, Sakabe, Kou, Okada, Yoshinori, Matsuyama, Daisuke, Kuroiwa, Masahiro, Mochida, Joji
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects Apoptosis - physiology Cell Line, Tumor - drug effects Cell Line, Tumor - metabolism Endoplasmic reticulum stress Endoplasmic Reticulum Stress - drug effects Endoplasmic Reticulum Stress - genetics Endoplasmic Reticulum Stress - physiology Genes, Synthetic Glial cell Glioma - pathology Glutamate Glutamic Acid - toxicity GRP78 Heat-Shock Proteins - biosynthesis Heat-Shock Proteins - genetics Heat-Shock Proteins - physiology Nerve Tissue Proteins - biosynthesis Nerve Tissue Proteins - genetics Nerve Tissue Proteins - physiology Neurotoxins - toxicity Rats Recombinant Fusion Proteins - biosynthesis Recombinant Fusion Proteins - genetics Tunicamycin Tunicamycin - toxicity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!