Nerve growth factor induces type III collagen production in chronic allergic airway inflammation

Background Excessive extracellular matrix deposition occurs as a result of repetitive injury-repair cycles and plays a central role in the pathogenesis of chronic inflammatory diseases, such as allergic asthma. The molecular mechanism leading to aberrant collagen deposition is not fully understood....

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Veröffentlicht in:	Journal of allergy and clinical immunology 2011-11, Vol.128 (5), p.1058-1066.e4
Hauptverfasser:	Klç, Ayşe, MSc, Sonar, Sanchaita Sriwal, PhD, Yildirim, Ali Oender, MD, Fehrenbach, Heinz, PhD, Nockher, Wolfgang Andreas, PhD, Renz, Harald, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Airway Remodeling Allergic asthma Allergy and Immunology Animals Asthma - metabolism Asthma - pathology Biological and medical sciences Chronic Disease Chronic obstructive pulmonary disease, asthma Collagen Collagen Type III - biosynthesis Cytokines Cytokines - biosynthesis Disease Experiments Female Fibroblasts - metabolism Fundamental and applied biological sciences. Psychology Fundamental immunology Hypersensitivity - metabolism Hypersensitivity - pathology Immunopathology Kinases Medical sciences Mice Mice, Inbred C57BL nerve growth factor Nerve Growth Factor - metabolism Pneumology Proteins Pulmonary Fibrosis - metabolism Pulmonary Fibrosis - pathology RNA, Messenger - analysis RNA, Small Interfering Rodents Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Transfection type III collagen Wound healing
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