Structural requirement of phenylthiourea analogs for their inhibitory activity of melanogenesis and tyrosinase

Molcad docking models have the compound 1e (A) and 2b (B) in the active site. Effect of a series of 1-phenylthioureas 1a– k and 1,3-disubstituted thioureas 2a– k were evaluated against melanin formation in melanoma B16 cell line and mushroom tyrosinase. Inhibitory activity of tyrosinase of 1-phenylt...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2011-11, Vol.21 (22), p.6824-6828
Hauptverfasser:	Thanigaimalai, Pillaiyar, Lee, Ki-Cheul, Sharma, Vinay K., Joo, Cheonik, Cho, Won-Jea, Roh, Eunmiri, Kim, Youngsoo, Jung, Sang-Hun
Format:	Artikel
Sprache:	eng
Schlagworte:	1,3-Disubstituted thioureas 1-Phenylthioureas Agaricales - enzymology Animals Biological and medical sciences Catalytic Domain Cell Line, Tumor chemistry Docking study Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Humans Medical sciences melanin Melaninogenic inhibitor Melanins - antagonists & inhibitors Melanins - metabolism melanogenesis melanoma Melanoma, Experimental - metabolism Models, Molecular Monophenol Monooxygenase - antagonists & inhibitors Monophenol Monooxygenase - chemistry Monophenol Monooxygenase - metabolism mushrooms Pharmacology. Drug treatments Phenylthiourea - analogs & derivatives Phenylthiourea - pharmacology thiourea Tyrosinase inhibitor
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!