Selective vulnerability of rat brain regions to unconjugated bilirubin

Hippocampus is one of the brain regions most vulnerable to unconjugated bilirubin (UCB) encephalopathy, although cerebellum also shows selective yellow staining in kernicterus. We previously demonstrated that UCB induces oxidative stress in cortical neurons, disruption of neuronal network dynamics,...

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Veröffentlicht in:	Molecular and cellular neuroscience 2011-09, Vol.48 (1), p.82-93
Hauptverfasser:	Vaz, Ana Rita, Silva, Sandra L., Barateiro, Andreia, Falcão, Ana Sofia, Fernandes, Adelaide, Brito, Maria A., Brites, Dora
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bilirubin - pharmacology Brain - anatomy & histology Brain - drug effects Brain - metabolism Cell Death - drug effects Cells, Cultured Cerebellum Cortex Cyclic GMP - metabolism DJ-1 Hippocampus Hippocampus - cytology Humans Immature neurons Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Neurite outgrowth and branching Neurons - cytology Neurons - drug effects Neurons - metabolism Nitric Oxide Synthase - genetics Nitric Oxide Synthase - metabolism Nitrites - metabolism Oxidation-Reduction Oxidative and nitrosative stress Oxidative Stress - drug effects Protein Deglycase DJ-1 Rats Rats, Wistar Reactive Oxygen Species - metabolism Unconjugated bilirubin
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