Closed-Loop Deep Brain Stimulation Is Superior in Ameliorating Parkinsonism

Continuous high-frequency deep brain stimulation (DBS) is a widely used therapy for advanced Parkinson's disease (PD) management. However, the mechanisms underlying DBS effects remain enigmatic and are the subject of an ongoing debate. Here, we present and test a closed-loop stimulation strateg...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2011-10, Vol.72 (2), p.370-384
Hauptverfasser:	Rosin, Boris, Slovik, Maya, Mitelman, Rea, Rivlin-Etzion, Michal, Haber, Suzanne N., Israel, Zvi, Vaadia, Eilon, Bergman, Hagai
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basal Ganglia - physiopathology Cercopithecus aethiops Deep Brain Stimulation - methods Electrodes Globus Pallidus - physiopathology Monkeys & apes MPTP Poisoning - chemically induced MPTP Poisoning - physiopathology MPTP Poisoning - therapy Neurons - physiology Neurosciences Parkinson Disease, Secondary - chemically induced Parkinson Disease, Secondary - physiopathology Parkinson Disease, Secondary - therapy Parkinson's disease Primates Treatment Outcome
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